Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE:Persicae Semen (Taoren) and Carthami Flos (Honghua) used in pair which is named as Taoren-Honghua (TH) herb pair has been used in traditional Chinese medicine (TCM) for promoting blood circulation to dissipate blood stasis for many years in China. AIM OF THE STUDY:This paper investigated the effects of TH and its main components amygdalin and hydroxysafflor yellow A (HSYA) on hemorheological disorders of blood stasis in rats. MATERIALS AND METHODS:Rats were randomly divided into seven groups (control group, model group, TH group, amygdalin group, HSYA group, amygdalin+HSYA group, and aspirin group) with eight animals in each, whose gender was equally distributed throughout groups. All treatments were performed by gavage and administered seven times with an interval of 12h. After the fifth administration, the model rats except those in control group with blood stasis were established by being placed in ice-cold water during the interval between two injections of adrenaline hydrochloride (Adr); and blood samples were collected 30min after the last administration on the following day. RESULTS:TH could significantly decrease whole blood viscosity (WBV), plasma viscosity (PV) and packed cell volume (PCV). It also significantly prolonged thrombin time (TT) and thromboplastin time (APTT), increased prothrombin time (PT) and lowered fibrinogen content (FIB). HSYA which significantly decreased WBV and PV had no effect on plasma coagulation parameters. Amygdalin could significantly decrease PV, prolong APTT and decrease FIB, showing few effects on WBV. TH and its main components amygdalin and HSYA could significantly reduce platelet aggregation and protect vascular endothelial cells. Based on the above results, amygdalin and HSYA were responsible for the main curative effects of TH and usually had synergetic effects, such as decreasing PV and platelet aggregation percentage. CONCLUSIONS:The study may provide scientific information to further understanding of the mechanism(s) of TH and its main components in activating blood circulation to dissipate blood. It may also create valuable insight into the possible effects and utilization of TH and its components as a feasible alternative therapeutic agent for patients with hemorheological disorders.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Liu L,Duan JA,Tang Y,Guo J,Yang N,Ma H,Shi Xdoi
10.1016/j.jep.2011.11.016subject
Has Abstractpub_date
2012-01-31 00:00:00pages
381-7issue
2eissn
0378-8741issn
1872-7573pii
S0378-8741(11)00823-3journal_volume
139pub_type
杂志文章abstract::Murdannia bracteata has been used as a Taiwanese folk medicine for its anti-inflammatory properties. However, neither its active ingredients nor its anti-inflammatory actions are well defined. Nitric oxide (NO), overproduced by activated macrophages via inducible NO synthase (iNOS), is suggested to be a significant pa...
journal_title:Journal of ethnopharmacology
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更新日期:2007-06-13 00:00:00
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journal_title:Journal of ethnopharmacology
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更新日期:1986-03-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:G. pentaphyllum, also known as Jiao-Gu-Lan, has been used traditionally as folk remedies for many diseases, including diabetes mellitus, metabolic syndrome, aging, and neurodegenerative diseases in China and some countries in East and Southeast Asia. It is considered as an "immortality he...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
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更新日期:2021-03-25 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2006.10.012
更新日期:2007-04-04 00:00:00
abstract::We studied the effect of Acanthopanax senticosus stem (ACPS) on mast cell-dependent anaphylaxis. ACPS inhibited compound 48/80-induced systemic anaphylaxis at a dose of 1.0 g/kg by 50%. ACPS also inhibited passive cutaneous anaphylaxis reaction and histamine release from mast cells in a dose-dependent manner, respecti...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2002-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2021-01-30 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Zanthoxylum nitidum (Roxb.) DC. is a traditional Chinese medicine characterised by anti-inflammatory and anti-Helicobacter pylori, which is widely used to treat H. pylori-induced gastric disease in China. However, the underlying mechanism related to its anti-H. pylori activity remains unc...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.jep.2006.09.005
更新日期:2006-11-24 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2010.05.026
更新日期:2010-11-11 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Bullatine A, a C20-diterpenoid alkaloid and one of the major effective ingredients in Aconiti brachypodi Radix (Xue-shang-yi-zhi-hao), can block pain hypersensitivity in a variety of rodent models through expression of spinal microglial dynorphin A. AIM OF THE STUDY:To assess the interac...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2017-01-20 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.jep.2014.10.014
更新日期:2014-12-02 00:00:00
abstract::The widespread development of anthelmintic resistance and high cost of the conventional anthelmintic drugs, has limited the control of gastrointestinal nematode parasites of sheep and goats and hence led to evaluation of medicinal plants as an alternative source of anthelmintics. In the current study, in vitro ovicida...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2009.01.014
更新日期:2009-03-18 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2018.12.039
更新日期:2019-04-06 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2019-05-10 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2013.08.038
更新日期:2013-10-28 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2000-09-01 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2007-12-03 00:00:00
abstract::Pteleopsis suberosa Engl. et Diels was used in the traditional medicine of Mali for the treatment of gastric and duodenal ulcers. In an ethnopharmacological approach, Pteleopsis suberosa extracts of the stem bark were investigated for antiulcer and antibacterial activity against Helicobacter pylori standard strains an...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
abstract::The effects of beta-sitosterol on fertility, epididymal sperm counts and testicular and accessory reproductive organ weights were evaluated in male albino rats. The effects were studied at two dosages (0.5 and 5 mg/kg per day rat subcutaneously) for 16, 32 and 48 days. The antifertility effect of beta-sitosterol was p...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:1991-12-01 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2016-03-02 00:00:00
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journal_title:Journal of ethnopharmacology
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doi:10.1016/j.jep.2013.07.015
更新日期:2013-09-16 00:00:00
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journal_title:Journal of ethnopharmacology
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更新日期:2013-10-28 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Plants from genus Lavandula have been used as anti-inflammatory drugs in Mediterranean traditional medicine. Nowadays, there is a growing interest for complementary medicine, including herbal remedies, to treat inflammatory bowel disease (IBD). AIM OF THE STUDY:To test the anti-inflammat...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2016-08-22 00:00:00
abstract::The anti-hyperglycemic action of Hei-Shug-Pian, the fire-processed product of the root of Aconitum (Aconitum carmichaeli), was investigated in streptozotocin-induced diabetic (STZ-diabetic) rats. At 120 min following oral administration of Hei-Shug-Pian at doses ranging from 12.5 to 50 mg/kg, plasma glucose of STZ-dia...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2006.01.001
更新日期:2006-06-30 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Wound healing is an important area of research in contemporary medicine. Unani is a traditional medicine system based on hundreds of years of observations and experiences. Wounds are described under the headings qarha (arabic) and jarāhat (persian) in classical Unani texts. Several drugs ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
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更新日期:2020-07-15 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Hyptis fruticosa is a plant native to Brazil with antinociceptive and antiinflamatory properties. This study evaluated the antinociceptive activity of the hydroethanol extract of the plant leaves (CHEE) against orofacial pain as well as its in vitro effect against lipid peroxidation. MAT...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2013-03-07 00:00:00
abstract::Malaria, caused by parasites of the genus Plasmodium, is one of the leading infectious diseases in many tropical regions, including Nigeria, a West African country where transmission occurs all year round. Many of the inhabitants use plants as remedies against fever and other symptoms of acute malaria, as reported her...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
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更新日期:2011-01-27 00:00:00