当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > The plasma glucose lowering action of Hei-Shug-Pian, the fire-processed product of the root of Aconitum (Aconitum carmichaeli), in streptozotocin-induced diabetic rats.

The plasma glucose lowering action of Hei-Shug-Pian, the fire-processed product of the root of Aconitum (Aconitum carmichaeli), in streptozotocin-induced diabetic rats.

Abstract：

:The anti-hyperglycemic action of Hei-Shug-Pian, the fire-processed product of the root of Aconitum (Aconitum carmichaeli), was investigated in streptozotocin-induced diabetic (STZ-diabetic) rats. At 120 min following oral administration of Hei-Shug-Pian at doses ranging from 12.5 to 50 mg/kg, plasma glucose of STZ-diabetic rats was found to be decreased in a dose-dependent manner. Under treatment conditions wherein plasma glucose was lowered, the uptake of glucose into soleus muscle was increased and the incorporation of glucose into glycogen of hepatocytes was enhanced. The plasma glucose-lowering effect of Hei-Shug-Pian was eliminated by blockade of opioid mu-receptors. Moreover, Hei-Shug-Pian treatment failed to lower plasma glucose in opioid mu-receptor knockout diabetic mice. The findings obtained in this study support the conclusion that Hei-Shug-Pian lowers the plasma glucose concentrations of STZ-diabetic rats through activation of opioid mu-receptors of peripheral tissues, resulting in enhanced glucose utilization.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Liou SS,Liu IM,Lai MC

doi

10.1016/j.jep.2006.01.001

keywords:

subject

Has Abstract

pub_date

2006-06-30 00:00:00

pages

256-62

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(06)00007-9

journal_volume

106

pub_type

杂志文章

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