当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Orofacial antinociceptive effect and antioxidant properties of the hydroethanol extract of Hyptis fruticosa salmz ex Benth.

Orofacial antinociceptive effect and antioxidant properties of the hydroethanol extract of Hyptis fruticosa salmz ex Benth.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Hyptis fruticosa is a plant native to Brazil with antinociceptive and antiinflamatory properties. This study evaluated the antinociceptive activity of the hydroethanol extract of the plant leaves (CHEE) against orofacial pain as well as its in vitro effect against lipid peroxidation. MATERIALS AND METHODS:The antinociceptive activity was investigated in mice orally treated with different doses of the CHEE (50, 100, and 200 mg/kg) and morphine (5 mg/kg) using formalin, glutamate, and capsaicin orofacial pain models using. Lipoperoxidation was induced in egg yolk by AAPH and FeSO4 in the absence and presence of the CHEE (5, 50, 100, and 150 μg/mL). RESULTS:CHEE (200 mg/kg) significantly reduced (ρ<0.001) the pain response in the first (69.6%) and second (81.8%) phases of the formalin test, while the nociception caused by capsaicin was significantly (ρ<0.001) reduced by up to 62% at 200 mg/kg of extract. When glutamate was used as algogen, a significant (ρ<0.001) nociception reduction of up to 85% at 200 mg/kg extract was observed. CHEE showed a higher protection against lipoperoxidation caused by FeSO4 (82.3% TBARS inhibition) than AAPH (35.7% TBARS inhibition) at 150 μg/mL. CONCLUSION:Hyptis fruticosa leaf CHEE is of pharmacological interest because it was able to inhibit the peripheral and central transmission of orofacial pain, while reducing the spreading of the inflammatory processes by neutralizing reactive oxygen species, which are by-products in the biosynthesis of pain mediators.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

de Lima AC,Paixão MS,Melo M,de Santana MT,Damascena NP,Dias AS,Porto YC,Fernandes XA,Santos CC,Lima CA,Quintans Júnior LJ,dos S Estevam C,Araújo BS

doi

10.1016/j.jep.2012.12.031

subject

Has Abstract

pub_date

2013-03-07 00:00:00

pages

192-7

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(12)00865-3

journal_volume

146

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Studies on antimycotic properties of Datura metel.

    abstract：:The hexane, chloroform, acetone and methanolic fractions of Datura metel L. were investigated for antifungal properties using pathogenic species of Aspergillus. The chloroform fraction was found to be endowed with antifungal activity. The minimum inhibitory concentration (MIC) of chloroform fraction of D. metel L. was...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00036-3

    authors： Rajesh,Sharma GL

    更新日期：2002-05-01 00:00:00

  • Antimicrobial activity of Schinus lentiscifolius (Anacardiaceae).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Schinus lentiscifolius Marchand (syn. Schinus weinmannifolius Engl) is a plant native to Rio Grande do Sul (Southern Brazil) and has been used in Brazilian traditional medicine as antiseptic and antimicrobial for the treatment of many different health problems as well as to treat leucorrh...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.04.043

    authors： Gehrke IT,Neto AT,Pedroso M,Mostardeiro CP,Da Cruz IB,Silva UF,Ilha V,Dalcol II,Morel AF

    更新日期：2013-07-09 00:00:00

  • In vitro purgative effect of Ruellia praetermissa. Sceinf.ex.Lindau (Acanthaceae).

    abstract：:Methanol, ethylacetate and aqueous extracts of Ruellia praetermissa initiated spontaneous contractions in the quiescent and increased contraction on the electrically stimulated ileal strip at a concentration of 30 microg/ml. The extracts produced concentration-related contractions both in amplitude and tone up till 75...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(00)00204-x

    authors： Salah AM,Dongmo AB,Kamanyi A,Bopelet M,Vierling W,Wagner H

    更新日期：2000-09-01 00:00:00

  • The water expelling effect evaluation of 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol and ingenol on H22 mouse hepatoma ascites model and their content differences analysis in Euphorbia kansui before and after stir-fried with vinegar by UPLC.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Malignant ascites (MA) effusion is mainly caused by hepatocellular, ovarian, and breast cancer etc. It has been reported that Euphorbia kansui (EK), the root of Euphorbia kansui S.L.Liou ex S.B.Ho, possessing a therapeutic effect on MA. However, the clinical applications of EK are serious...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113507

    authors： Zhang Q,Ju YH,Zhang Y,Wang K,Zhang M,Chen PD,Yao WF,Tang YP,Wu JH,Zhang L

    更新日期：2021-03-01 00:00:00

  • Fasciolicidal efficacy of Albizia anthelmintica and Balanites aegyptiaca compared with albendazole.

    abstract：:An attempt was made to evaluate the oral doses of 9 g/kg-body weight of Albizzia anthelmintica Brong. Mimoaseae stem bark water extract and 9 g/kg body weight of B. aegyptiaca (L) Del. (Balanitaceae) fruit mesocarp water extract (traditionally used as an anthelmintic in the Sudan) compared with 20 mg/kg body weight (r...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(00)00172-0

    authors： Koko WS,Galal M,Khalid HS

    更新日期：2000-07-01 00:00:00

  • Pharmacological study on antidepressant activity of 50% ethanol extract of a formulated ayurvedic product in rats.

    abstract：:The effects of 50% ethanol extract of one formulated ayurvedic product, consisting of a mixture of medicinal plant species, was investigated on behavioral despair test (forced swimming test, FST), central dopaminergic and serotonergic activity in rats. The effects on the forced swimming test were assessed along with t...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(00)00232-4

    authors： Bopaiah CP,Pradhan N,Venkataram BS

    更新日期：2000-10-01 00:00:00

  • A RNA-seq approach for exploring the protective effect of ginkgolide B on glutamate-induced astrocytes injury.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:There is substantial experimental evidence to support the view that Ginkgo biloba L. (Ginkgoaceae), a traditional Chinese medicine known to treating stroke, has a protective effect on the central nervous system and significantly improves the cognitive dysfunction caused by disease, includ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2021.113807

    authors： Wang J,Zhuang L,Ding Y,Wang Z,Xiao W,Zhu J

    更新日期：2021-01-12 00:00:00

  • Comprehensive evaluation on anti-inflammatory and anti-angiogenic activities in vitro of fourteen flavonoids from Daphne Genkwa based on the combination of efficacy coefficient method and principal component analysis.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Genkwa flos, as a traditional herb, is the dried flower buds of Daphne genkwa Sieb.et Zucc. It is used in traditional medicine for the treatment of cough, sore throats, edema. AIM OF THE STUDY:The study aimed to explore a new mathematical method for multivariate evaluation, investigate t...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113683

    authors： Zhou DC,Zheng G,Jia LY,He X,Zhang CF,Wang CZ,Yuan CS

    更新日期：2021-03-25 00:00:00

  • In-vitro (2D and 3D cultures) and in-vivo cytotoxic properties of Zataria multiflora essential oil (ZEO) emulsion in breast and cervical cancer cells along with the investigation of immunomodulatory potential.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Zataria multiflora is an iranian valuable traditional plants, called Avishan Shirazi in Persian language used to reduce inflammation, spasm, pain, and cancer symptoms. Zataria essential oil (ZEO) is one of the essential oils possessing broad biological activities. AIM OF THE STUDY:The ai...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112865

    authors： Azadi M,Jamali T,Kianmehr Z,Kavoosi G,Ardestani SK

    更新日期：2020-07-15 00:00:00

  • Mechanisms of anti-inflammatory effect of an active ingredients group from Jinxuan Zhike Xunxi San.

    abstract：AIM OF THE STUDY:JZXS has been used for inflamed hemorrhoids as a chinese prescription for several decades. The present study was designed to investigate the anti-inflammatory activities, as well as the mechanisms, of an active ingredients group (AIG) obtained from Jinxuan Zhike Xunxi San (JZXS). MATERIALS AND METHODS...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.03.019

    authors： Wen L,Zhou L,Liu W,Huang H,Li Y,Wang H,Zhang W,Liu Y

    更新日期：2011-05-17 00:00:00

  • Evaluation of Senegalese plants used in malaria treatment: focus on Chrozophora senegalensis.

    abstract：:An ethnobotanical study was conducted in the Dakar area of Senegal to investigate the species used in the treatment of malaria. Seven plants are principally used: Cissampelos mucronata, Maytenus senegalensis, Terminalia macroptera, Bidens engleri, Ceratotheca sesamoides, Chrozophora senegalensis and Mitracarpus scaber...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.10.033

    authors： Benoit-Vical F,Soh PN,Saléry M,Harguem L,Poupat C,Nongonierma R

    更新日期：2008-02-28 00:00:00

  • Wound healing activity of Calotropis gigantea root bark in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Calotropis gigantea R.Br. (Asclepiadaceae) is a perennial undershrub found chiefly in wastelands throughout India. It has been reported as a traditional folkloric medicine for a variety of alignments. The plant Calotropis gigantea is also used in some parts of India for wound healing in c...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.06.007

    authors： Deshmukh PT,Fernandes J,Atul A,Toppo E

    更新日期：2009-08-17 00:00:00

  • Treatment with Azadirachta indica in diabetic pregnant rats: negative effects on maternal outcome.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The role of Azadirachta indica (neem) against Chagas disease and its antibiotic and antidiabetic action have been demonstrated in non-pregnant animals. However, the effects of neem on lipid metabolism and oxidative stress during pregnancy remain to be investigated. The objective of this s...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.07.023

    authors： Dallaqua B,Saito FH,Rodrigues T,Calderon IM,Rudge MV,Herrera E,Damasceno DC

    更新日期：2012-10-11 00:00:00

  • A simple high-performance liquid chromatographic method for the determination of brazilin and its application to a pharmacokinetic study in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Caesalpinia sappan is a medicinal plant native to China popularly used to treat chronic pelvic inflammation, dysmenorrhea and hysteromyoma. Its main bioactive component is brazilin which had presented antibacterial, anti-inflammatory and anti-platelet aggregation activities. To establish ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.08.054

    authors： Yan-yan J,Yan L,Ying S,Jinyi Z,Fang D,Yuan S,Ai-dong W

    更新日期：2014-01-01 00:00:00

  • Anxiolytic effects of the aqueous extract of Uncaria rhynchophylla.

    abstract：:The purpose of this study was to characterize the putative anxiolytic-like effects of the aqueous extract of hooks with stem of Uncaria rhynchophylla using the elevated plus maze (EPM) and the hole-board apparatus in rats and mice. Control rats were treated with an equal volume of saline, and positive control rats wit...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.05.019

    authors： Jung JW,Ahn NY,Oh HR,Lee BK,Lee KJ,Kim SY,Cheong JH,Ryu JH

    更新日期：2006-11-24 00:00:00

  • Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Rosmarinic acid (RA), a caffeic acid-related compound found in high concentrations in Prunella vulgaris (self-heal), and ursolic acid (UA), a pentacyclic triterpene acid concentrated in Salvia officinalis (sage), have been traditionally used to treat inflammation in the mouth, and may als...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.07.037

    authors： Qiang Z,Ye Z,Hauck C,Murphy PA,McCoy JA,Widrlechner MP,Reddy MB,Hendrich S

    更新日期：2011-10-11 00:00:00

  • Anti-inflammatory activity of Eupatorium perfoliatum L. extracts, eupafolin, and dimeric guaianolide via iNOS inhibitory activity and modulation of inflammation-related cytokines and chemokines.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Eupatorium perfoliatum L. has been used traditionally for the treatment of fever, malaria and inflammation-associated diseases. Nowadays it is mostly used as immune activating remedy. The following study was performed to evaluate extracts with different polarity and defined lead-compounds...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.05.040

    authors： Maas M,Deters AM,Hensel A

    更新日期：2011-09-01 00:00:00

  • Histoarchitecture of the genital tract of ovariectomized rats treated with an aqueous extract of Moringa oleifera roots.

    abstract：:The effect of an aqueous extract of Moringa oleifera roots was studied histologically on the genital tract of ovariectomized rats in the presence and absence of estradiol dipropionate and progesterone. Administration of the extract itself stimulated the uterine histoarchitecture as revealed by increases in the height ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(89)90031-7

    authors： Shukla S,Mathur R,Prakash AO

    更新日期：1989-05-01 00:00:00

  • Management of diabetic complications: a chemical constituents based approach.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Long term hyperglycemia leads to development of complications associated with diabetes. Diabetic complications are now a global health problem without effective therapeutic approach. Hyperglycemia and oxidative stress are important components for the development of diabetic complications....

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2013.08.051

    authors： Singh R,Kaur N,Kishore L,Gupta GK

    更新日期：2013-10-28 00:00:00

  • Intestinal anti-inflammatory effects of fuzi-ganjiang herb pair against DSS-induced ulcerative colitis in mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Fuzi and ganjiang are widely used as traditional Chinese medicines (TCM) in China, Korea, Japan, and many other southeast Asian countries for treating ulcerative colitis (UC), emesis and heart failure for more than 1800 years. However, the underlying mechanism of fuzi, ganjiang and fuzi-g...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112951

    authors： Huang C,Dong J,Jin X,Ma H,Zhang D,Wang F,Cheng L,Feng Y,Xiong X,Jiang J,Hu L,Lei M,Wu B,Zhang G

    更新日期：2020-10-28 00:00:00

  • Effect of Chinese herbal medicine on stroke patients with type 2 diabetes.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Complications of type 2 diabetes (T2D) include stroke, which is a cerebrovascular disturbance characterized by reduced blood flow in the brain, leading to death or physical disability. Chinese herbal medicine (CHM) has been widely used in ancient China for the treatment of diabetes and st...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.02.024

    authors： Tsai FJ,Ho TJ,Cheng CF,Liu X,Tsang H,Lin TH,Liao CC,Huang SM,Li JP,Lin CW,Lin JG,Lin JC,Lin CC,Liang WM,Lin YJ

    更新日期：2017-03-22 00:00:00

  • Ethnopharmacological survey of medicinal plants used in Daraa-Tafilalet region (Province of Errachidia), Morocco.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:We carried out an ethnobotanical survey in Tafilalet region. This region is classified by the UNESCO as a reserve of biosphere and represents an important area with important knowledge of traditional medicine, especially the use of medicinal plants for human healthcare. Furthermore, the g...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.12.017

    authors： Eddouks M,Ajebli M,Hebi M

    更新日期：2017-02-23 00:00:00

  • Establishment of an in vitro system based on AGM-S3 co-culture for screening traditional herbal medicines that stimulate hematopoiesis.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Spatholobus suberectus Dunn is a traditional Chinese medicine (TCM) that can activate blood, dispel stasis, inhibit platelet aggregation, and stimulate hematopoiesis, and thereby treat anemia and diseases related to blood stasis syndrome (BSS). However, its hematopoiesis-stimulating activ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.111938

    authors： Chang J,Sun W,Zeng J,Xue Y,Zhang Y,Pan X,Zhou Y,Lai M,Bian G,Zhou Q,Liu J,Chen B,Guo F,Ma F

    更新日期：2019-08-10 00:00:00

  • Medicinal plants of the Meinit ethnic group of Ethiopia: an ethnobotanical study.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The majority of the Ethiopian people, including the Meinit ethnic group, are highly dependent on medicinal plants for their day-to-day public healthcare and veterinary needs. The existence of medicinal plants and the associated knowledge is, however, currently being threatened mainly due ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.05.009

    authors： Giday M,Asfaw Z,Woldu Z

    更新日期：2009-07-30 00:00:00

  • Rosmarinus officinalis L. hydroalcoholic extract, similar to fluoxetine, reverses depressive-like behavior without altering learning deficit in olfactory bulbectomized mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Rosemary, Rosmarinus officinalis L., has several therapeutic applications in folk medicine for the treatment of a wide range of diseases, including depression. AIM OF THE STUDY:To evaluate the ability of Rosmarinus officinalis hydroalcoholic extract (ROHE), as compared to the positive cont...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.06.017

    authors： Machado DG,Cunha MP,Neis VB,Balen GO,Colla AR,Grando J,Brocardo PS,Bettio LE,Dalmarco JB,Rial D,Prediger RD,Pizzolatti MG,Rodrigues AL

    更新日期：2012-08-30 00:00:00

  • Evaluation of potential herb-drug interactions between oseltamivir and commonly used anti-influenza Chinese medicinal herbs.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:According to Traditional Chinese Medicine theory, influenza is categorized as a warm disease or Wen Bing. The Wen Bing formulas, such as Yin-Qiao-San and Sang-Ju-Yin, are still first-line herbal therapies in combating variant influenza virus. To continue our study on the pharmacokinetic a...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112097

    authors： Zhang Y,Lyu C,Fong SYK,Wang Q,Li C,Ho NJ,Chan KS,Yan X,Zuo Z

    更新日期：2019-10-28 00:00:00

  • Nyctanthes arbor-tristis Linn--a critical ethnopharmacological review.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Nyctanthes arbor-tristis (Oleaceae) is a mythological plant; has high medicinal values in Ayurveda. The popular medicinal use of this plant are anti-helminthic and anti-pyretic besides its use as a laxative, in rheumatism, skin ailments and as a sedative. Vitally, the natives plant it in ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2013.01.024

    authors： Agrawal J,Pal A

    更新日期：2013-04-19 00:00:00

  • Further studies on the hepatoprotective effects of Cochlospermum tinctorium rhizomes.

    abstract：:The hepatoprotective activity of the rhisome of Cochlospermum tinctorium was investigated using carbon tetrachloride toxicity on mouse and tert-butyl hydroperoxide in vitro induction of lipid peroxidation and hepatocyte lysis. Aqueous, hydro-ethanolic and ethanolic extracts showed significant dose-dependent hepatoprot...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(92)90013-h

    authors： Diallo B,Vanhaelen-Fastre R,Vanhaelen M,Fiegel C,Joyeux M,Roland A,Fleurentin J

    更新日期：1992-04-01 00:00:00

  • The gastroprotective activity of the ethanol extract of Ageratum conyzoides.

    abstract：:The ethanol extract of Ageratum conyzoides was evaluated for gastroprotection in rats using the Ibuprofen, ethanol and cold restraint stress ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and ulcer index. Oral administration of the ethanol extract at dose levels of 500 and 750 mg...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00050-3

    authors： Shirwaikar A,Bhilegaonkar PM,Malini S,Kumar JS

    更新日期：2003-05-01 00:00:00

  • Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Radix paeoniae rubra, also known as chishao (CS), is a frequently used traditional Chinese medicine that can promote blood circulation to remove blood stasis. It has been widely used for the prevention and treatment of cardiovascular diseases in China. Although terpene glycoside (TG), the...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.05.028

    authors： Ke Z,Wang G,Yang L,Qiu H,Wu H,Du M,Chen J,Song J,Jia X,Feng L

    更新日期：2017-07-12 00:00:00