Anxiolytic effects of the aqueous extract of Uncaria rhynchophylla.

Abstract:

:The purpose of this study was to characterize the putative anxiolytic-like effects of the aqueous extract of hooks with stem of Uncaria rhynchophylla using the elevated plus maze (EPM) and the hole-board apparatus in rats and mice. Control rats were treated with an equal volume of saline, and positive control rats with buspirone (1 mg/kg). Single or repeated treatments of the aqueous extract of Uncaria rhynchophylla (200 mg/kg/day, p.o.) for 7 days significantly increased the time-spent and entries into open arms of the EPM, and reduced the time-spent and entries into the closed arms versus saline controls (P<0.05). However, no changes in spontaneous locomotor activity or myorelaxant effects were observed versus saline controls. In the hole-board test, repeated treatment with the aqueous extract of Uncaria rhynchophylla (100 or 200 mg/kg/day, p.o.) significantly increased the number of head-dips (P<0.05). In addition, the anxiolytic-like effects of Uncaria rhynchophylla extract as assessed using the EPM test were abolished by WAY 100635 (0.3 mg/kg, i.p.), a 5-HT(1A) receptor antagonist. These results suggest that Uncaria rhynchophylla is an effective anxiolytic agent, and acts via the serotonergic nervous system.

journal_name

J Ethnopharmacol

authors

Jung JW,Ahn NY,Oh HR,Lee BK,Lee KJ,Kim SY,Cheong JH,Ryu JH

doi

10.1016/j.jep.2006.05.019

subject

Has Abstract

pub_date

2006-11-24 00:00:00

pages

193-7

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(06)00272-8

journal_volume

108

pub_type

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