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Mechanisms of anti-inflammatory effect of an active ingredients group from Jinxuan Zhike Xunxi San.

Abstract：

AIM OF THE STUDY:JZXS has been used for inflamed hemorrhoids as a chinese prescription for several decades. The present study was designed to investigate the anti-inflammatory activities, as well as the mechanisms, of an active ingredients group (AIG) obtained from Jinxuan Zhike Xunxi San (JZXS). MATERIALS AND METHODS:The anti-inflammatory activities and mechanisms of AIG were evaluated by xylene-induced ear edema experiments in normal mice and mice without adrenals, leukocyte migration experiments, and carrageenin-induced peritonitis experiments, taking JZXS as the positive control. RESULTS:AIG and JZXS prevented xylene-induced ear edema in normal mice but showed no effects when adrenals were removed. Additionally, AIG and JZXS inhibited leukocyte migration, reduced prostaglandin E2 (PGE2) level in inflammatory exudates and nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-6 and 8 (IL-6 and IL-8) levels in serum. CONCLUSIONS:AIG and JZXS showed significant anti-inflammatory activities depending on pituitary-adrenal axis, thereby inhibiting leukocyte migration and reducing cytokines and mediators.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Wen L,Zhou L,Liu W,Huang H,Li Y,Wang H,Zhang W,Liu Y

doi

10.1016/j.jep.2011.03.019

subject

Has Abstract

pub_date

2011-05-17 00:00:00

pages

308-12

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(11)00155-3

journal_volume

135

pub_type

杂志文章

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