Abstract:
:The ethanol extract of Ageratum conyzoides was evaluated for gastroprotection in rats using the Ibuprofen, ethanol and cold restraint stress ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and ulcer index. Oral administration of the ethanol extract at dose levels of 500 and 750 mg/kg significantly protected gastric lesions by 80.59 and 89.33%, respectively, as compared to Misoprostol (74.43%) in the Ibuprofen model; by 97.09 and 99.24%, respectively, in the cold stress model as compared to Famotidine (77.86 and 92.71%) and by 86.58 and 92.29%, respectively, in the alcohol model. The findings suggest that the significant gastroprotective activity could be mediated by its antioxidant activity, Ca(2+) channel blocking and antiserotogenic properties.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Shirwaikar A,Bhilegaonkar PM,Malini S,Kumar JSdoi
10.1016/s0378-8741(03)00050-3keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
117-21issue
1eissn
0378-8741issn
1872-7573pii
S0378874103000503journal_volume
86pub_type
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journal_title:Journal of ethnopharmacology
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