Further studies on the hepatoprotective effects of Cochlospermum tinctorium rhizomes.

Abstract:

:The hepatoprotective activity of the rhisome of Cochlospermum tinctorium was investigated using carbon tetrachloride toxicity on mouse and tert-butyl hydroperoxide in vitro induction of lipid peroxidation and hepatocyte lysis. Aqueous, hydro-ethanolic and ethanolic extracts showed significant dose-dependent hepatoprotective actions. The ethanolic extract showed a hepatoprotective activity at lower doses than silymarin. The ethanolic and hydro-ethanolic extracts exhibited remarkable effects against the induction of lipid peroxidation and hepatocyte lysis; the aqueous extract showed comparatively weaker effects. These differences were related to the chemical composition of the extracts. Among the identified constituents of the drug, phenolic and polyphenolic compounds (gallic and ellagic acids, ellagitannins, flavonoids), carotenoids, triterpenes could be related to the biological activity.

journal_name

J Ethnopharmacol

authors

Diallo B,Vanhaelen-Fastre R,Vanhaelen M,Fiegel C,Joyeux M,Roland A,Fleurentin J

doi

10.1016/0378-8741(92)90013-h

keywords:

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

137-42

issue

2

eissn

0378-8741

issn

1872-7573

pii

0378-8741(92)90013-H

journal_volume

36

pub_type

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