Abstract：
:The benzoquinone embelin and four alkyl phenols were isolated from an Argentinean collection of Oxalis erythrorhiza. 3-Heptadecyl-5-methoxy-phenol is reported for the first time. The structures were determined by spectroscopic methods. Embelin presented inhibitory effect on methicillin-resistant Staphylococcus aureus, Escherichia coli and the dermatophytic fungi Epidermophyton floccosum, Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes and Trichophyton rubrum with MICs ranging between 50 and 100 microg/ml. Furthermore, embelin was active against Trypanosoma cruzi trypomastigotes with 100% lysis at 100 microg/ml and cytotoxicity below the trypanocidal concentration. The new alkyl phenol 3-heptadecyl-5-methoxy-phenol was active towards Leishmania amazonensis and Leishmania donovani promastigotes with 100% lysis at 100 microg/ml. The cytotoxicity (IC50) of embelin and the new alkyl phenol on human lung fibroblasts were 739 and 366 microM, respectively. The plant is used to treat heart complains, a symptomatology related to Chagas' disease which is endemic in the San Juan Province, Argentine.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Feresin GE,Tapia A,Sortino M,Zacchino S,de Arias AR,Inchausti A,Yaluff G,Rodriguez J,Theoduloz C,Schmeda-Hirschmann Gdoi
10.1016/s0378-8741(03)00258-7keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
241-7issue
2-3eissn
0378-8741issn
1872-7573pii
S0378874103002587journal_volume
88pub_type
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journal_title：Journal of ethnopharmacology
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