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Involvement of the PI3K/AKT pathway in the hypoglycemic effects of saponins from Helicteres isora.

Abstract：

AIM OF THE STUDY:Saponins from Helicteres isora have previously been shown to exert antidiabetic effects. The present study explored the underlying mechanisms in C2C12 skeletal muscle cells. MATERIALS AND METHODS:C2C12 cells were incubated with saponins and sapogenin followed by Western blotting and immunofluorescence analysis. RESULTS:Western blotting revealed that incubation with saponins (100 microg/ml) and sapogenin (100 microg/ml) induced the phosphorylation of the phosphatidylinositol-3-kinase (PI3K) as well as of the downstream targets protein kinase B/Akt (at Ser473) and glycogen synthase kinase GSK-3 alpha/beta (at Ser21/9) in a time-dependent manner. In contrast, no phosphorylation of the AMP-sensitive kinase AMPK (at Thr172) was observed. Within 48 h saponins/sapogenin treatment further increased the protein abundance of the insulin-sensitive glucose transporter Glut4. Confocal microscopy confirmed that saponins/sapogenin treatment stimulated Akt phosphorylation and revealed that the treatment was followed by translocation of Glut4 into the cell membrane of C2C12 muscle cells. CONCLUSIONS:Saponins and sapogenin activate the PI3K/Akt pathway thus leading to phosphorylation and inactivation of GSK-3 alpha/beta with subsequent stimulation of glycogen synthesis as well as increase of Glut4-dependent glucose transport across the cell membrane.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Bhavsar SK,Föller M,Gu S,Vir S,Shah MB,Bhutani KK,Santani DD,Lang F

doi

10.1016/j.jep.2009.09.027

subject

Has Abstract

pub_date

2009-12-10 00:00:00

pages

386-96

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(09)00587-X

journal_volume

126

pub_type

杂志文章

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