当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Neuroprotective effects of xiao-xu-ming decoction against ischemic neuronal injury in vivo and in vitro.

Neuroprotective effects of xiao-xu-ming decoction against ischemic neuronal injury in vivo and in vitro.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Xiao-Xu-Ming decoction (XXMD) has long been employed clinically to treat stroke in traditional Chinese Medicine. AIM OF THE STUDY:To investigate the neuroprotective effects of XXMD in vivo and in vitro stroke models and determine involved mechanisms. MATERIALS AND METHODS:Two models (four-vessel occlusion in adult Wistar rats and oxygen-glucose deprivation primary cultured neurons) were employed to mimic ischemia-reperfusion damage, in vivo and in vitro, respectively. The effects of XXMD were investigated with respect to neuronal damage, activity of caspase-3 and expression of Bcl-2 in CA1 region of hippocampus after ischemia. The cognitive ability was measured 7 days after ischemia/reperfusion by using Morris water maze. RESULTS:Oral administration of XXMD significantly increased the density of neurons that survived in the CA1 region of hippocampus on the 3rd and 7th day after transient global ischemia was induced in a dose-dependent manner. XXMD ameliorated severe deficiencies in spatial cognitive performance induced by transient global ischemia. Inhibition of caspase-3 activity and up-regulation of Bcl-2 expression were induced in the high dose of XXMD-treated rats after ischemia. In oxygen-glucose deprivation model, both XXMD extract and drug-containing serum prepared from blood of high dose of XXMD-treated rats inhibited apoptotic neuronal death at 24h after reoxygenation. CONCLUSIONS:Our results clearly demonstrated that XXMD is neuroprotective and appears to influence deleterious pathological processes that are activated after the onset of ischemia.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Zhu XH,Li SJ,Hu HH,Sun LR,Das M,Gao TM

doi

10.1016/j.jep.2009.09.054

subject

Has Abstract

pub_date

2010-01-08 00:00:00

pages

38-46

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(09)00614-X

journal_volume

127

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Acute toxicity, antinociceptive activity and indole alkaloids of aqueous extract from bark of Aspidosperma cuspa (Kunth) Blake.

    abstract：UNLABELLED:ETNOPHARMACOLOGICAL RELEVANCE: Aspidosperma cuspa (Kunth) Blake (Apocynaceae) is popularly known as "amargosa" or "cuspa", and its bark is used in folk medicine primarily for pain. AIM OF THE STUDY:In the present study the acute toxicity, antinociceptive effect and alkaloids of the aqueous decoction extract...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.07.021

    authors： Pérez NM,Torrico FB,Morales A

    更新日期：2012-09-28 00:00:00

  • The effects of Qi Teng Xiao Zhuo granules, traditional Chinese medicine, on the expression of genes in chronic glomerulonephritis rats.

    abstract：BACKGROUND AND AIM:Chronic glomerulonephritis (CGN) is a primary glomerular disease that is related to immune-mediated inflammatory diseases. Qi Teng Xiao Zhuo granules have been proposed as a prescription of traditional Chinese medicine for treatment of CGN, but the comprehensive molecular mechanism underlying this th...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.08.011

    authors： Gao JR,Qin XJ,Jiang H,Wang T,Song JM,Xu SZ

    更新日期：2016-12-04 00:00:00

  • Analysis of estrogenic compounds in Polygonum cuspidatum by bioassay and high performance liquid chromatography.

    abstract：:The estrogenic activity of traditional Chinese herb-Polygonum cuspidatum Sieb. et Zucc. was investigated by a recombinant yeast screening (YES) assay. Anthraquinones are the main components in the plant, of which emodin is the most abundant one. The ethyl acetate fraction of the ethanol extract of Polygonum cuspidatum...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.10.029

    authors： Zhang C,Zhang X,Zhang Y,Xu Q,Xiao H,Liang X

    更新日期：2006-04-21 00:00:00

  • Digitalis: is there a future for this classical ethnopharmacological remedy?

    abstract：:Withering's (1741-1799) greatest merit is not so much that of having discovered the therapeutic value of foxglove in hydropsy, since this indication (among others) was already part of traditional medicine, but actually during a decade of carefully recording clinical observations, he authoritatively settled definite gu...

    journal_title：Journal of ethnopharmacology

    pub_type： 历史文章,杂志文章

    doi：10.1016/0378-8741(91)90109-q

    authors： Marullaz PD

    更新日期：1991-04-01 00:00:00

  • Evaluation of Nigerian traditional medicine: effects of Gakani, a herbal anti-asthmatic drug.

    abstract：:The anti-asthmatic potential of Gakani, a popular herbal drug in Nigeria was investigated. The LD50 values of the freeze-dried aqueous extract in mice and rats were 20.9 +/- 2.4 mg/kg and 18.6 +/- 4 mg/kg, respectively. The extract unsurmountably blocked the effects of histamine and isoprenaline on the guinea pig trac...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(96)01475-4

    authors： Akah PA,Gamaniel KS,Samson A,Wambebe CO

    更新日期：1997-01-01 00:00:00

  • Ginkgo biloba extracts for tinnitus: More hype than hope?

    abstract：:The investigation into the effects of Ginkgo biloba extracts on tinnitus has suffered from a dearth of effective animal models as well as systematic clinical trials employing double-blind and placebo-controlled designs. Some clinical trials have yielded positive results, however, these studies are few and have been li...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2005.05.032

    authors： Smith PF,Zheng Y,Darlington CL

    更新日期：2005-08-22 00:00:00

  • Dragon's Blood extract has antithrombotic properties, affecting platelet aggregation functions and anticoagulation activities.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Dragon's Blood from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China), as a traditional Chinese medicinal herb, was shown to have certain antithrombotic effects. A new preparation process was used to extract effective components from Dragon's Blood. A 95% ethanol extract A (EA) a...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.03.063

    authors： Xin N,Li YJ,Li Y,Dai RJ,Meng WW,Chen Y,Schlappi M,Deng YL

    更新日期：2011-05-17 00:00:00

  • Environmental impact evaluation of the stem bark extract of Maesa lanceolata used in Democratic Republic of Congo.

    abstract：:This study has been carried out in order to evaluate new chemical drugs from plants for biocidal activity before use to avoid noxious effect on human beings and animals or plants and also to prevent the worsing of environment. In fact, many natural products endowed with biological active principles are obtained from p...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.11.036

    authors： Bagalwa M,Chifundera K

    更新日期：2007-12-03 00:00:00

  • The evaluation of hepatoprotective effects of Taiwan folk medicine 'teng-khia-u'.

    abstract：:'Teng-khia-u' is a folk medicine of Taiwan, derived from the entire plants of Elephantopus scaber L., E. mollis H.B.K. and Pseudoelephantopus spicatus (Juss.) Rohr. The hepatoprotective effects of water extracts of these three plants against beta-D-galactosamine (D-GalN)- and acetaminophen (APAP)-induced acute hepatic...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(94)01198-9

    authors： Lin CC,Tsai CC,Yen MH

    更新日期：1995-02-01 00:00:00

  • Tanzania's policy on biodiversity prospecting and drug discovery programs.

    abstract：:Tanzania is endowed with a rich natural resource. The biodiversity comprises over 10,000 plant species, a rich fauna and marine resources. The collection of biological resources is guided by a set of formalities, namely: (i) entry visas, (ii) research permits, (iii) designation of a relevant collaborating host institu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0378-8741(95)01365-2

    authors： Mahunnah RL,Mshigeni KE

    更新日期：1996-04-01 00:00:00

  • Antimutagenic potential of homoisoflavonoids from Muscari racemosum.

    abstract：:The potential antimutagenic effect of the plant extract of Muscari racemosum bulbs, rich on 3-benzylidene-4-chromanones, was evaluated on three genetic model organisms. The mixture of three homoisoflavonoids was applied together with diagnostic mutagens in the Ames assay on four bacterial strains Salmonella typhimuriu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00135-6

    authors： Miadoková E,Masterová I,Vlcková V,Dúhová V,Tóth J

    更新日期：2002-08-01 00:00:00

  • Andrographis paniculata: Dissolution investigation and pharmacokinetic studies of four major active diterpenoids after multiple oral dose administration in healthy Thai volunteers.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Andrographis paniculata is included in 'The National List of Essential Herbal Drugs A.D. 1999' of Thailand as an herbal drug for the treatment of common cold symptoms and non-infectious diarrhea. The therapeutic activities of A. paniculata are attributed to four major active diterpenoids:...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.09.058

    authors： Pholphana N,Panomvana D,Rangkadilok N,Suriyo T,Puranajoti P,Ungtrakul T,Pongpun W,Thaeopattha S,Songvut P,Satayavivad J

    更新日期：2016-12-24 00:00:00

  • Shikonin induces cell cycle arrest in human gastric cancer (AGS) by early growth response 1 (Egr1)-mediated p21 gene expression.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Lithospermum erythrorhizon, a naphthoquinone compound derived from a shikonin, has long been used as traditional Chinese medicine for treatment of various diseases, including cancer. To evaluate the cytotoxic effects of shikonin on AGS gastric cancer cells via induction of cell cycle arre...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.11.055

    authors： Kim SJ,Kim JM,Shim SH,Chang HI

    更新日期：2014-02-12 00:00:00

  • Suppressive effects of methoxyflavonoids isolated from Kaempferia parviflora on inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The rhizomes of Kaempferia parviflora Wall. ex Baker have been traditionally used in Thailand to treat abscesses, gout, and peptic ulcers. AIM:Previously, we reported that the chloroform fraction of a Kaempferia parviflora extract had an inhibitory effect on rat paw-edema. In the present...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.01.013

    authors： Sae-Wong C,Matsuda H,Tewtrakul S,Tansakul P,Nakamura S,Nomura Y,Yoshikawa M

    更新日期：2011-07-14 00:00:00

  • The aqueous extract of Terminalia superba (Combretaceae) prevents glucose-induced hypertension in rats.

    abstract：AIM OF THE STUDY:The stem bark of Terminalia superba (Combretaceae) (TS) is used in traditional Cameroonian medicine as antihypertensive remedy. The aim of this study was to investigate the hypotensive and the antihypertensive effects of the aqueous extract of the stem bark of Terminalia superba. MATERIALS AND METHODS...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.11.016

    authors： Tom EN,Demougeot C,Mtopi OB,Dimo T,Djomeni PD,Bilanda DC,Girard C,Berthelot A

    更新日期：2011-01-27 00:00:00

  • Endothelium-dependent vasorelaxing activity of aqueous extracts of lyophilized seeds of Casimiroa edulis (AECe) on rat mesenteric arterial bed.

    abstract：:The vasorelaxing activity of the aqueous extracts of Casimiroa edulis seeds F(AECe) on mesenteric arterial bed (MAB) of rats was studied. MAB precontracted with methoxamine was mounted on a tissue bath and exposed to plant extracts (bolus 50, 500, 2500 and 5000 microg). The bolus injections of AECe significantly inhib...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.06.018

    authors： Baisch AL,Urban H,Ruiz AN

    更新日期：2004-12-01 00:00:00

  • The immunostimulatory effects and chemical characteristics of heated honey.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In traditional Chinese medicine (TCM), honey has been used as an additive in the heat-processing of herbal medicines to enhance their immunostimulatory activities. AIM OF THE STUDY:We investigated the immunostimulatory activity of heated honey in vitro and in vivo. MATERIALS AND METHODS...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.09.019

    authors： Ota M,Ishiuchi K,Xu X,Minami M,Nagachi Y,Yagi-Utsumi M,Tabuchi Y,Cai SQ,Makino T

    更新日期：2019-01-10 00:00:00

  • Protection of mouse brain from paracetamol-induced stress by Centella asiatica methanol extract.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Centella asiatica (CA) is a medicinal herb traditionally used as a brain tonic in Ayurvedic medicine. Various ethnomedical leads revealed the effective use of CA in the treatment of symptoms associated to oxidative stress and inflammation. AIM OF THE STUDY:The aim of this study was to ev...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.03.017

    authors： Viswanathan G,Dan VM,Radhakrishnan N,Nair AS,Rajendran Nair AP,Baby S

    更新日期：2019-05-23 00:00:00

  • Immunomodulatory functions of extracts from the Chinese medicinal fungus Cordyceps cicadae.

    abstract：:The effects of Cordyceps cicadae extracted fractions on human mononuclear cells (HMNC) proliferation were determined by tritiated thymidine uptake. The results indicated that aqueous methanol (50%) extracts of C. cicadae ascocarps portion (CC-1-2) enhanced HMNC proliferation activated with phytohemagglutinin (PHA) wit...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00212-x

    authors： Weng SC,Chou CJ,Lin LC,Tsai WJ,Kuo YC

    更新日期：2002-11-01 00:00:00

  • Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Neuroinflammation, oxidative stress, and protein aggregation form a vicious cycle in the pathophysiology of Parkinson's disease (PD); activated microglia is the main location of neuroinflammation. A Chinese medicine book, "Shanghan Lun", known as the "Treatises on Cold damage Diseases" ha...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.10.040

    authors： Hung KC,Huang HJ,Wang YT,Lin AM

    更新日期：2016-12-24 00:00:00

  • Nitrites and nitrates in the human diet: Carcinogens or beneficial hypotensive agents?

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The presence of nitrite in the human diet was thought to constitute a hazard as secondary nitrosamines are known to cause gastric cancers. MATERIALS AND METHODS:Recent publications on the physiology of serum nitrite have been consulted. PROBLEMS:Nitrite is added to some foodstuffs as an...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.09.040

    authors： Butler A

    更新日期：2015-06-05 00:00:00

  • Bufei Yishen granules combined with acupoint sticking therapy suppress oxidative stress in chronic obstructive pulmonary disease rats: Via regulating peroxisome proliferator-activated receptor-gamma signaling.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Traditional Chinese medicine (TCM) is clinically used under the guidance of its unique theory system. Bufei Yishen (BY) granules, an oral Chinese herbal formula, is confirmed effective for treating the syndrome of lung-kidney qi deficiency in chronic obstructive pulmonary disease (COPD) p...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.08.027

    authors： Li Y,Tian YG,Li JS,Dong YQ,Wang MH,Feng SX,Li LL,Mao J,Wang LL,Luo S

    更新日期：2016-12-04 00:00:00

  • Preclinical toxicological evaluations of the sclerotium of Lignosus rhinocerus (Cooke), the Tiger Milk mushroom.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Lignosus rhinocerus (Tiger Milk mushroom) is distributed in South China, Thailand, Malaysia, Indonesia, Philippines and Papua New Guinea. In Malaysia, it is the most popular medicinal mushroom used by the indigenous communities to relieve fever, cough, asthma, cancer, food poisoning and a...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.02.027

    authors： Lee SS,Enchang FK,Tan NH,Fung SY,Pailoor J

    更新日期：2013-05-02 00:00:00

  • Synergistic interaction between the Ligusticum chuanxiong constituent butylidenephthalide and the nitric oxide donor sodium nitroprusside in relaxing rat isolated aorta.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ligusticum chuanxiong Hort. (Umbelliferae), a traditional Chinese medicinal herb, is often prescribed together with nitric oxide donors for treating coronary heart diseases such as angina in China; however, studies concerning their pharmacological interaction are scarce. AIM OF THE STUDY...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.01.002

    authors： Chan SS,Jones RL,Lin G

    更新日期：2009-03-18 00:00:00

  • The methanolic extract of Boesenbergia rotunda (L.) Mansf. and its major compound pinostrobin induces anti-ulcerogenic property in vivo: possible involvement of indirect antioxidant action.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Boesenbergia rotunda (L) Mansf. has been used for the treatment of gastrointestinal disorders including peptic ulcer. In the current study we aimed to investiagte the anti-ulcer activities of methanolic extract of B. rotunda (MEBR) and its main active compound, pinostrobin on ethanol-indu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.07.010

    authors： Abdelwahab SI,Mohan S,Abdulla MA,Sukari MA,Abdul AB,Taha MM,Syam S,Ahmad S,Lee KH

    更新日期：2011-09-02 00:00:00

  • Ethnopharmacological survey of medicinal plants used in Daraa-Tafilalet region (Province of Errachidia), Morocco.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:We carried out an ethnobotanical survey in Tafilalet region. This region is classified by the UNESCO as a reserve of biosphere and represents an important area with important knowledge of traditional medicine, especially the use of medicinal plants for human healthcare. Furthermore, the g...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.12.017

    authors： Eddouks M,Ajebli M,Hebi M

    更新日期：2017-02-23 00:00:00

  • Effects of the Turkish subspecies of Viscum album on macrophage-derived cytokines.

    abstract：:Viscum album L. herbs are used for the treatment of various diseases. Apart from their immunostimulatory, antitumor, and hypotension inducing activities, anti-inflammatory effects has also been recorded in the literature. Since the immunostimulatory activity of mistletoe is mainly attributed to a stimulation of the mo...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(98)00038-5

    authors： Yesilada E,Deliorman D,Ergun F,Takaishi Y,Ono Y

    更新日期：1998-07-01 00:00:00

  • Antimicrobial activity of the methanolic extract, fractions and four flavonoids from the twigs of Dorstenia angusticornis Engl. (Moraceae).

    abstract：:The methanolic extract (DAT), fractions (FRS) and four flavonoids, namely Gancaonin Q (1), Stipulin (2), Angusticornin B (3) and Bartericin A (4), isolated from the twigs of Dorstenia angusticornis (Moraceae), were tested for their in vitro antimicrobial activity. A total of 22 microbial cultures belonging to three Ca...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.03.008

    authors： Kuete V,Simo IK,Ngameni B,Bigoga JD,Watchueng J,Kapguep RN,Etoa FX,Tchaleu BN,Beng VP

    更新日期：2007-06-13 00:00:00

  • Possible mechanisms of action of Caesalpinia pyramidalis against ethanol-induced gastric damage.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Caesalpinia pyramidalis Tul. (Fabaceae), known as "catingueira", is an endemic tree of the Northeast region of Brazil. This plant, mainly inner bark and flowers, has been used in traditional medicine to treat gastritis, heartburn, indigestion, stomachache, dysenteries, and diarrheas. MAT...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.03.054

    authors： Diniz PB,Ribeiro AR,Estevam CS,Bani CC,Thomazzi SM

    更新日期：2015-06-20 00:00:00

  • Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formation.

    abstract：AIM OF THE STUDY:To examine the effect of Bacopa monniera leaf ethanolic extract (BMEE) on the serotonergic system of postnatal rats with reference to learning and memory. MATERIALS AND METHODS:From postnatal day (PND)-15-29, rats were treated with BMEE (40 mg/kg BW+0.5% gum acacia) by oral gavage. Behavioural tests (...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.11.045

    authors： Charles PD,Ambigapathy G,Geraldine P,Akbarsha MA,Rajan KE

    更新日期：2011-03-08 00:00:00