当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Shikonin induces cell cycle arrest in human gastric cancer (AGS) by early growth response 1 (Egr1)-mediated p21 gene expression.

Shikonin induces cell cycle arrest in human gastric cancer (AGS) by early growth response 1 (Egr1)-mediated p21 gene expression.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Lithospermum erythrorhizon, a naphthoquinone compound derived from a shikonin, has long been used as traditional Chinese medicine for treatment of various diseases, including cancer. To evaluate the cytotoxic effects of shikonin on AGS gastric cancer cells via induction of cell cycle arrest. MATERIALS AND METHODS:We observed the effects of 12.5-100 ng/mL dosage of shikonin treatment on AGS cancer cell line with the incubation time of 6h. Cytotoxic effects were assessed by measuring the changes in the intracellular ROS, appearance of senescence phenotype, cell cycle progression, CDK and cyclins expression levels upon shikonin treatment. We also examined upon the activation of Egr1-mediated p21 expression, by siRNA transfection, Luciferase assay, and ChIP assay. RESULTS:In this study, we found that shikonin inhibits cell proliferation by arresting cell cycle progression at the G2/M phase via modulation of p21 in AGS cells. Also, our results revealed that the p21 gene was transactivated by early growth response1 (Egr1) in response to the shikonin treatment. Transient Egr1 expression enhanced shikonin-induced p21 promoter activity, whereas the suppression of Egr1 expression by small interfering RNA attenuated the ability of shikonin to induce p21 promoter activity. CONCLUSION:Our results suggested that the anti-proliferative activity of shikonin was due to its ability to induce cell cycle arrest via Egr1-p21 signaling pathway. Thus, the work stated here validates the traditional use of shikonin in the treatment of cancer.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Kim SJ,Kim JM,Shim SH,Chang HI

doi

10.1016/j.jep.2013.11.055

subject

Has Abstract

pub_date

2014-02-12 00:00:00

pages

1064-1071

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(13)00859-3

journal_volume

151

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Enigma of drug-induced altered states of consciousness among the !Kung Bushmen of the Kalahari Desert.

    abstract：:This article examines data presented in Katz' book, Boiling Energy: Community Healing among the Kalahari Kung, particularly with regard to plant drugs present in the community during the 1968 visit. The author argues that the similarity of the Bushman trance state, kia and that of drug-induced altered states of consci...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(86)90168-6

    authors： Dobkin De Rios M

    更新日期：1986-03-01 00:00:00

  • In vitro anti-glycation activity of the marine plant Posidonia oceanica (L.) Delile.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The marine plant Posidonia oceanica (L.) Delile is traditionally used by villagers of the west coast of Anatolia as a remedy for diabetes and hypertension. AIM OF THE STUDY:The aim of this study was to explore the role of the P. oceanica hydroalcoholic leaves extract (POE) against human ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112960

    authors： Vasarri M,Barletta E,Ramazzotti M,Degl'Innocenti D

    更新日期：2020-09-15 00:00:00

  • Apigenin attenuates TGF-β1-stimulated cardiac fibroblast differentiation and extracellular matrix production by targeting miR-155-5p/c-Ski/Smad pathway.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Apigenin is a natural flavonoid compound present in chamomile (Matricaia chamomilla L.) from the Asteraceae family, which is used in the treatment of cardiovascular diseases by traditional healers, but its effects on differentiation and extracellular matrix (ECM) production of cardiac fib...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113195

    authors： Wang F,Fan K,Zhao Y,Xie ML

    更新日期：2021-01-30 00:00:00

  • Anticancer medicinal plants used by Moroccan people: Ethnobotanical, preclinical, phytochemical and clinical evidence.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cancer is a major health problem worldwide. Drugs' side effects and high cost of treatment remain the main limitations of conventional therapy. Nowadays, developing new therapeutic strategies is necessary. Therefore, medicinal plants can be used to promote novel, safe, and potent anticanc...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2020.113435

    authors： Alami Merrouni I,Elachouri M

    更新日期：2021-02-10 00:00:00

  • Integrated pharmacokinetics of five protoberberine-type alkaloids in normal and insomnic rats after single and multiple oral administration of Jiao-Tai-Wan.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Jiao-Tai-Wan (JTW), an important herbal formula consists of Rhizoma coptidis and Cortex cinnamomi powder, is a famous prescription which has been used for centuries to treat insomnia in Traditional Chinese Medicine. The purpose of this study is to compare the pharmacokinetic properties of...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.04.040

    authors： He W,Liu G,Cai H,Sun X,Hou W,Zhang P,Xie Z,Liao Q

    更新日期：2014-07-03 00:00:00

  • Metabolomic strategy to study therapeutic and synergistic effects of tanshinone IIA, salvianolic acid B and ginsenoside Rb1 in myocardial ischemia rats.

    abstract：AIM OF THE STUDY:Tanshinone IIA (T), salvianolic acid B (S) and ginsenoside Rb1 (G) are the three major active ingredients of Compound Danshen Formula (CDF) for its protective effects on myocardial ischemia (MI). In this study, we aimed to investigate therapeutic and synergistic effects of TSG (combination of T, S and ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.11.048

    authors： Lu Y,Liu X,Liang X,Xiang L,Zhang W

    更新日期：2011-03-08 00:00:00

  • Possible involvement of amine oxidase inhibition in the sympathetic activation induced by khat (Catha edulis) chewing in humans.

    abstract：:The possibility that phenylalkylamines (cathinone and cathine) of khat, like amphetamines, are amine oxidase inhibitors with clinical significance is evaluated. Results show that khat chewing induces a significant increase in blood pressure, body temperature and urinary catecholamines in khat naive subjects. On the ot...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(84)90097-7

    authors： Nencini P,Amiconi G,Befani O,Abdullahi MA,Anania MC

    更新日期：1984-06-01 00:00:00

  • Increase of ejaculatory capacity by systemic administration of the oquichpatli (Senecio cardiophyllus) aqueous crude extract in male rats.

    abstract：AIM OF THE STUDY:To analyse the pro-ejaculatory properties of the proverbial Mexican plant oquichpatli, Senecio cardiophyllus, in an animal model for the study of ejaculation in spinal and anaesthetised male rats. MATERIALS AND METHODS:The aqueous crude extract of Senecio cardiophyllus (at 0.4, 1.2 and 4 mg/kg) was i....

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.09.006

    authors： Carro-Juárez M,Alcazar C,Ballesteros-Polvo E,Villalobos-Peñalosa P

    更新日期：2009-12-10 00:00:00

  • Pharmacologic effects of an aqueous extract of Rhigiocarya racemifera.

    abstract：:Several pharmacologic studies were carried out with an aqueous extract of Rhigiocarya racemifera after phytochemical tests revealed the main constituents to be glycosides, saponins and tannins. Studies on intact mice showed that the extract has an intraperitoneal LD50 of 142 mg/kg and that 50 mg/kg of the extract redu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(86)90151-0

    authors： Aguwa CN

    更新日期：1986-02-01 00:00:00

  • Phenylethanol glycosides from Cistanche tubulosa improved reproductive dysfunction by regulating testicular steroids through CYP450-3β-HSD pathway.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cistanche tubulosa (Schenk) R. Wight has been used frequently in traditional folk medicine for treatment of male sexual dysfunction (MSD). Phenylethanol glycosides, the main components of C. tubulosa, possess a variety of pharmacological activities due to their multiple properties. Howeve...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112500

    authors： Wang Q,Dong J,Lu W,He H,Sun X,Zhang K,Song Q,Jiang Y,Wang Y,Li C,Tu P

    更新日期：2020-04-06 00:00:00

  • The optimal dose of arsenic trioxide induced opposite efficacy in autophagy between K562 cells and their initiating cells to eradicate human myelogenous leukemia.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Arsenic trioxide (As2O3), a main component of arsenolite which is a common traditional Chinese medicine (TCM) wildly used as a therapeutic agent for more than 2400 years in china, has been accepted as a standard treatment for the patients with acute promyelocytic leukemia (APL) based on t...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.12.010

    authors： Guo Z,Meng M,Geng S,Du Z,Zheng Y,Yao J,Li Z,Han G,Lin H,Du G

    更新日期：2017-01-20 00:00:00

  • The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In traditional Chinese medicine, processed aconite root (lateral root of Aconitum carmichaelii Debx.) is used as the principle herb of the Si-Ni decoction (SND) formula due to its cardiotonic effect, while its cardiotoxicity and neurotoxicity caused by diester and monoester diterpenoid al...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.09.022

    authors： Zhang M,Peng Y,Wang M,Gao B,Zhao L,Li X

    更新日期：2019-01-10 00:00:00

  • 1-Triacontanol cerotate; isolated from Marsilea quadrifolia Linn. ameliorates reactive oxidative damage in the frontal cortex and hippocampus of chronic epileptic rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Marsilea quadrifolia Linn. (MQ) has been used for insomnia and epileptic disorders in traditional Indian medicine. The present study is to isolate the active component responsible for antiepileptic property of MQ by evaluating its ability to minimize the reactive oxidative damage in brain...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.06.020

    authors： Snehunsu A,Ghosal C,Kandwal M,Yadav PK,Nayak BS,Rao KR,Kamath SU,Sahoo P,Srinivasan KK,Naduvil Narayanan S,Kumar S,Joseph A

    更新日期：2015-08-22 00:00:00

  • Antimicrobial activity of some important Adiantum species used traditionally in indigenous systems of medicine.

    abstract：:Adiantum Linn. of Adiantaceae family is one of the most common and widely distributed species. Ethnomedicinally, the genus is important and popularly known as "Hansraj" in Ayurvedic System of Medicine. It has been used in cold, tumors of spleen, liver and other viscera, skin diseases, bronchitis and inflammatory disea...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.09.018

    authors： Singh M,Singh N,Khare PB,Rawat AK

    更新日期：2008-01-17 00:00:00

  • Comparison on the anti-inflammatory effect of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cortex Phellodendri is derived from the dried bark of Phellodendron chinense Schneid. or Phellodendron amurense Rupr. Traditionally, Cortex Phellodendron Chinensis (CPC) and Cortex Phellodendron Amurensis (CPA) are used interchangeably under the name "Huang Bai" for the treatment of gastr...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.08.014

    authors： Xian YF,Mao QQ,Ip SP,Lin ZX,Che CT

    更新日期：2011-10-11 00:00:00

  • Tyrosinase modulation by five Rwandese herbal medicines traditionally used for skin treatment.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Traditional herbal medicines provide an interesting, largely unexplored source for the development of potential new drugs and skin-care cosmetics. Some herbal extracts are known to be inhibitors of melanin formation, sometimes more potent than the classical inhibitors, hydroquinone/arbuti...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.02.010

    authors： Kamagaju L,Morandini R,Bizuru E,Nyetera P,Nduwayezu JB,Stévigny C,Ghanem G,Duez P

    更新日期：2013-04-19 00:00:00

  • Effects of Fagonia cretica L. constituents on various haematological parameters in rabbits.

    abstract：:Effects of powdered Fagonia cretica plant and its two major triterpenoid saponins (saponin-I and saponin-II), isolated from its ethanolic extract, on red blood cells (RBC) count, haemoglobin concentration (HC), mean corpuscular haemoglobin (MCH) and on total leucocyte (WBC) count of normal male rabbits were investigat...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00365-3

    authors： Asif Saeed M,Wahid Sabir A

    更新日期：2003-04-01 00:00:00

  • Antihypertensive effect of Phragmanthera incana (Schum) Balle on NG-nitro-L-Arginine methyl ester (L-NAME) induced hypertensive rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Phragmanthera incana (Schum) Balle is a member of the African mistletoes that has been reported to be used in ethnomedicine for the treatment of hypertension. AIM:The aim of this study was to investigate the antihypertensive effect of Phragmanthera incana leaf ethanol extract (PILEE) in ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112888

    authors： Adedapo ADA,Ajayi AM,Ekwunife NL,Falayi OO,Oyagbemi A,Omobowale TO,Adedapo AA

    更新日期：2020-07-15 00:00:00

  • Jodina rhombifolia leaves lyophilized aqueous extract decreases ethanol intake and preference in adolescent male Wistar rats.

    abstract：:The leaves of Jodina rhombifolia (Hook. & Arn.) Reissek (Santalaceae) are utilized as anti-alcoholic in Argentine folk medicine. This study was designed to investigate the anti-alcohol properties in adolescent male Wistar rats (postnatal day 29; 83-105 g of weight). We utilized the "self-administration model", which e...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.07.046

    authors： Roberto Teves M,Wendel GH,Pelzer LE

    更新日期：2015-11-04 00:00:00

  • Role of cinnabar and realgar of WSHFD in protecting against LPS-induced neurotoxicity.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Wan-Sheng-Hua-Feng-Dan (WSHFD) is a traditional Chinese medicine used for the treatment of neurological disorders. Cinnabar (HgS) and realgar (As(4)S(4)) are included in WSHFD. Are they remedies or poisons? AIM OF STUDY:To investigate the role of cinnabar and realgar in the protective ef...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.12.026

    authors： Zhang F,Lu Y,Wu Q,Yan J,Shi J,Liu J

    更新日期：2012-02-15 00:00:00

  • Pharmacological evaluation of sedative-hypnotic activity and gastro-intestinal toxicity of Rhizoma Paridis saponins.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Rhizoma Paridis saponins (RPS) have been well studied for antimicrobial, anti-hemorrhagic, and anticancer effects. However, scientific information on RPS regarding the toxic and neuropharmacological effects is limited. In this study, the acute oral toxicity, sedative-hypnotic activity and...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.08.027

    authors： Liu Z,Gao W,Man S,Wang J,Li N,Yin S,Wu S,Liu C

    更新日期：2012-10-31 00:00:00

  • Immunostimulant activity of dry fruits and plant materials used in indian traditional medical system for mothers after child birth and invalids.

    abstract：:Products of certain plants given to mothers after child birth or to invalids were studied for immunostimulant activity using the macrophage migration index (MMI) as a parameter of macrophage activation and cell-mediated immunity and haemagglutinating antibody (HA) titres and plaque-forming cell (PFC) counts as paramet...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(99)00181-6

    authors： Puri A,Sahai R,Singh KL,Saxena RP,Tandon JS,Saxena KC

    更新日期：2000-07-01 00:00:00

  • Evaluation of the protective potential of Artemisia maritima extract on acetaminophen- and CCl4-induced liver damage.

    abstract：:The hepatoprotective activity of the aqueous-methanolic extract of Artemisia maritima was investigated against acetaminophen (paracetamol, 4-hydroxy acetanilide)- and carbon tetrachloride (CCl4)-induced hepatic damage. Acetaminophen produced 100% mortality at the dose of 1 g/kg in mice, while pretreatment of animals w...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(95)01252-9

    authors： Janbaz KH,Gilani AH

    更新日期：1995-06-23 00:00:00

  • Ethnobotanical survey and antibacterial activity of some plants used in Guinean traditional medicine.

    abstract：:A total of 418 healers have been interviewed in Guinea, a coastal country of West Africa, ranging between 7 degrees 30 and 12 degrees 30 of northern latitude and 8 degrees and 15 degrees of western longitude. Plant species used by the local inhabitants to treat infectious diseases were identified using ethnobotanical,...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.07.009

    authors： Magassouba FB,Diallo A,Kouyaté M,Mara F,Mara O,Bangoura O,Camara A,Traoré S,Diallo AK,Zaoro M,Lamah K,Diallo S,Camara G,Traoré S,Kéita A,Camara MK,Barry R,Kéita S,Oularé K,Barry MS,Donzo M,Camara K,Toté K,Be

    更新日期：2007-10-08 00:00:00

  • Chemical composition of the essential oil from the leaves of Piper fulvescens, a plant traditionally used in Paraguay.

    abstract：:The essential oil from the leaves of the aromatic aniseed smelling plant Piper fulvescens, obtained by hydrodistillation, was investigated by GC and GC-MS, as well as by 13C-NMR after fractionation of the oil by column chromatography. A total of 37 constituents, representing 78.2% of the oil were identified. The main ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00211-2

    authors： Vila R,Milo B,Tomi F,Casanova J,Ferro EA,Cañigueral S

    更新日期：2001-06-01 00:00:00

  • Morinda citrifolia Linn (Noni): in vivo and in vitro reproductive toxicology.

    abstract：UNLABELLED:Morinda citrifolia Linn (syn. Noni) is a plant widely used as food and medicine worldwide but there are no toxicological tests about this plant focused on reproduction. AIM OF THE STUDY:To investigate possible endocrine activity and toxic effect on the reproductive system of Wistar rats by exposure of aqueo...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.10.019

    authors： Müller JC,Botelho GG,Bufalo AC,Boareto AC,Rattmann YD,Martins ES,Cabrini DA,Otuki MF,Dalsenter PR

    更新日期：2009-01-21 00:00:00

  • Effect of ME-3451-106, an aqueous extract of Stichaster striatus with inhibitory activity of voluntary alcohol intake, in genetically drinker rats: Isolation and identification of the active fraction.

    abstract：:The aqueous extract obtained from Stichaster striatus Müller & Troschel (Asteroidea, Stichasteridae) has been shown to possess activity as an alcohol appetite inhibitor after oral administration in a rat model with a genetically established excessive appetite for alcohol (Wistar rats, lineage UChB). A significant decr...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.08.078

    authors： Font M,Bilbeny N,Contreras S,Paeile C,García H

    更新日期：2006-04-21 00:00:00

  • Hypoglycaemic and antihyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats.

    abstract：:The aqueous and alcoholic extracts of Trigonella foenum-graecum leaf were tested for hypoglycaemic activity in normal and alloxan-diabetic rats. Graded amounts (0.06, 0.2, 0.5, 1 g/kg, i.p. and 1, 2, 8 g/kg, p.o.) of the aqueous extract of Trigonella foenum-graecum leaf when given to both normal and alloxan-diabetic r...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(97)00101-3

    authors： Abdel-Barry JA,Abdel-Hassan IA,Al-Hakiem MH

    更新日期：1997-11-01 00:00:00

  • A history of the therapeutic use of liquorice in Europe.

    abstract：:Liquorice root has been used in Europe since prehistoric times, and is well documented in written form starting with the ancient Greeks. In this review we compare the independent development of medical uses of this botanical drug in several ancient cultures, attempting to show the rationality of specific indications a...

    journal_title：Journal of ethnopharmacology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.jep.2005.04.015

    authors： Fiore C,Eisenhut M,Ragazzi E,Zanchin G,Armanini D

    更新日期：2005-07-14 00:00:00

  • Modulation effect of Smilax glabra flavonoids on ryanodine receptor mediated intracellular Ca2+ release in cardiomyoblast cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Smilax glabra rhizome, a plant material from Liliaceae family, is a widely used traditional Chinese medicine for anti-cardiac hypertrophy treatment. We have previously found that Smilax glabra flavonoids (SGF) exerted such anti-cardiac hypertrophy activity. However, the mechanism of this ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.08.009

    authors： Shou Q,Pan S,Tu J,Jiang J,Ling Y,Cai Y,Chen M,Wang D

    更新日期：2013-10-28 00:00:00