Abstract：
UNLABELLED:Morinda citrifolia Linn (syn. Noni) is a plant widely used as food and medicine worldwide but there are no toxicological tests about this plant focused on reproduction. AIM OF THE STUDY:To investigate possible endocrine activity and toxic effect on the reproductive system of Wistar rats by exposure of aqueous extract of the Morinda citrifolia. MATERIALS AND METHODS:Two experimental protocols in vivo were developed, (a) uterotrophic assay and (b) in utero and lactational assay, and one test in vitro to investigate the effect on the contractility of pregnant uteri isolated from rats (doses of the extract: 7.5, 75 and 750 mg/kg). RESULTS:The uterotrophic assay indicates presence of in vivo antiestrogenic activity of extract at doses of 7.5 and 750 mg/kg. The in utero and lactation exposure showed that the treatment with extract at the dose of 7.5mg/kg induced a reduction of 50% in parturition index and an increase of 74% in postimplantation losses index. The in vitro test showed that uteri from rats treated with 7.5mg/kg of the extract presented a 50% reduction on contraction induced by arachidonic acid. CONCLUSION:The exposure of aqueous extract of Morinda citrifolia in Wistar rats induced reproductive toxicity in nonlinear dose-response.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Müller JC,Botelho GG,Bufalo AC,Boareto AC,Rattmann YD,Martins ES,Cabrini DA,Otuki MF,Dalsenter PRdoi
10.1016/j.jep.2008.10.019subject
Has Abstractpub_date
2009-01-21 00:00:00pages
229-33issue
2eissn
0378-8741issn
1872-7573pii
S0378-8741(08)00574-6journal_volume
121pub_type
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