当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Comparative acute toxicities and immunomodulatory potentials of five Eastern Nigeria mistletoes.

Comparative acute toxicities and immunomodulatory potentials of five Eastern Nigeria mistletoes.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Traditionally, mistletoes of Eastern Nigeria origin, Loranthus micranthus Linn. have been used as immunostimulant for the management of certain diseases with high profile immune depleting potentials. This practice has remained till date without scientific validation. AIM OF STUDY:To obtain and validate evidence for or against its continued use as immunostimulant and afford data for further studies on this specie of mistletoe. The present work is an in vivo proof of ethnopharmacological concept of the age long immunomodulatory use of our local mistletoe. MATERIALS AND METHODS:Aqueous-methanol extracts of the plant leaves from five different host trees were evaluated for immunomodulatory activity using four in vivo models in mice or rats, namely; total and differential leukocyte count (TLC and DLC), the cellular mediated delayed-type hypersensitivity reaction (DTHR) test, the humoral mediated antibody titration (AT) test and the cyclophosphamide-induced myelosuppression (CIM) test at different dose levels (100, 200 and 400 or 50, 100 and 250 mg kg(-1); depending on model) against standard controls. Phytochemical and acute toxicity tests were equally carried out on all the extracts. RESULTS:Results obtained indicate that all the mistletoes contained the same phytochemical constituents, although in varying amounts. The mistletoes exhibited statistically significantly different (p < 0.05 or p < 0.001, ANOVA) immunomodulatory (up-regulatory) activities in the overall order of that from Kola acuminata > Citrus spp > Persia americana > Parkia biglobosa > Pentaclatra macrophylla. LD(50) values were generally greater than 5000 mg/kg. CONCLUSION:The present study confirms the Eastern Nigeria mistletoe as a potent and safe alternative or complementary medicine for the management of immunodeficiency diseases.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Osadebe PO,Omeje EO

doi

10.1016/j.jep.2009.08.024

subject

Has Abstract

pub_date

2009-11-12 00:00:00

pages

287-93

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(09)00523-6

journal_volume

126

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Ethnomedicinal application of native remedies used against diabetes and related complications in Mauritius.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Notoriously, the tropical island of Mauritius has one of the highest prevalence of diabetes worldwide and the economic burden associated with it is alarming. The use of native remedies (NRs) is well anchored in the local culture and it continues to be the cornerstone of therapy for diabet...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.10.069

    authors： Mootoosamy A,Fawzi Mahomoodally M

    更新日期：2014-01-01 00:00:00

  • Evaluating the hematological and clinical-chemistry parameters of kratom (Mitragyna speciosa) users in Malaysia.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Kratom (Mitragyna speciosa Korth.) from the Rubiaceae family is an indigenous tropical medicinal tree of Southeast Asia. Kratom leaves have been used for decades in Malaysia and Thailand in traditional context for its perceived vast medicinal value, and as a mild stimulant among manual la...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.12.017

    authors： Singh D,Müller CP,Murugaiyah V,Hamid SBS,Vicknasingam BK,Avery B,Chear NJY,Mansor SM

    更新日期：2018-03-25 00:00:00

  • Tryptanthrin inhibits Th2 development, and IgE-mediated degranulation and IL-4 production by rat basophilic leukemia RBL-2H3 cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Tryptanthrin is a compound isolated from Polygonum tinctorium, which is a known folk medicine with various biological activities. AIM OF THE STUDY:Allergic diseases are initiated by the development of allergen-specific T helper type 2 (Th2) cells and amplified by the degranulation of and...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.12.041

    authors： Iwaki K,Ohashi E,Arai N,Kohno K,Ushio S,Taniguchi M,Fukuda S

    更新日期：2011-03-24 00:00:00

  • In vitro immunomodulating properties of selected Sudanese medicinal plants.

    abstract：:Ethanolic extracts of 23 medicinal plants, commonly used in Sudanese folk medicines against infectious diseases, were investigated for their immunomodulating activity using luminol/lucigenin-based chemiluminescence assay. Preliminary screenings on whole blood oxidative burst activity showed inhibitory activities of 14...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.03.007

    authors： Koko WS,Mesaik MA,Yousaf S,Galal M,Choudhary MI

    更新日期：2008-06-19 00:00:00

  • Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes.

    abstract：AIM:To validate plant species for hypoglycaemic activity. MATERIALS AND METHODS:Four plants were investigated for hypoglycaemic activity by evaluating inhibiting effects on carbohydrate-hydrolising enzymes: alpha-glucosidase and alpha-amylase. Acetone plant extracts were screened against C2C12 myocytes, 3T3-L1 preadip...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.04.052

    authors： Deutschländer MS,van de Venter M,Roux S,Louw J,Lall N

    更新日期：2009-07-30 00:00:00

  • Cajanus cajan Linn. (Leguminosae) prevents alcohol-induced rat liver damage and augments cytoprotective function.

    abstract：AIM OF THE STUDY:Cajanus cajan Linn. (Leguminosae) is a nontoxic edible herb, widely used in Indian folk medicine for the prevention of various liver disorders. In the present study we have demonstrated that methanol-aqueous fraction (MAF2) of Cajanus cajan leaf extract could prevent the chronically treated alcohol ind...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.05.010

    authors： Kundu R,Dasgupta S,Biswas A,Bhattacharya A,Pal BC,Bandyopadhyay D,Bhattacharya S,Bhattacharya S

    更新日期：2008-08-13 00:00:00

  • Danggui Buxue Tang promotes the adhesion and migration of bone marrow stromal cells via the focal adhesion pathway in vitro.

    abstract：ETHNOPHARMACOLOGY RELEVANCE:Danggui Buxue Tang has been used in China to treat clinical anemia for more than 800 years. However, there is no scientific report on its effect on bone marrow stromal cells. AIM OF THE STUDY:Here, we aimed to explore the effect of Danggui Buxue Tang on bone marrow stromal cell adhesion and...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.11.018

    authors： Bo H,He J,Wang X,Du R,Bei H,Chen J,Wang J,Wu F,Zhang W,Chen Q

    更新日期：2019-03-01 00:00:00

  • Ficus spp. (fig): ethnobotany and potential as anticancer and anti-inflammatory agents.

    abstract：:This review explores medieval, ancient and modern sources for ethnopharmacological uses of Ficus (fig) species, specifically for employment against malignant disease and inflammation. The close connection between inflammatory/infectious and cancerous diseases is apparent both from the medieval/ancient merging of these...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2008.06.025

    authors： Lansky EP,Paavilainen HM,Pawlus AD,Newman RA

    更新日期：2008-09-26 00:00:00

  • Central nervous system studies on an ethanol extract of Acorus calamus rhizomes.

    abstract：:An ethanol extract of Acorus calamus rhizomes was screened for CNS effects using a battery of 20 tests in rats and mice. The extract exhibited a large number of actions similar to alpha-asarone (an active principle of A. calamus) but differed from the latter in several other respects including the responses to electro...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(90)90065-2

    authors： Vohora SB,Shah SA,Dandiya PC

    更新日期：1990-02-01 00:00:00

  • Anti-aromatase activity of the constituents from damiana (Turnera diffusa).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Damiana (Turnera diffusa Willd. Ex Schult) has traditionally been used as an herbal aphrodisiac. AIM OF THE STUDY:The study was aimed to investigate the anti-aromatse activity and the estrogenic activity of the constituents isolated from Turnera diffusa. MATERIALS AND METHODS:The methan...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.09.016

    authors： Zhao J,Dasmahapatra AK,Khan SI,Khan IA

    更新日期：2008-12-08 00:00:00

  • Anti-nociceptive and anti-inflammatory effects of the ethanol extract of Arenga pinnata (Wurmb) Merr. fruit.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Arenga pinnata (Wurmb) Merr. is a medicinal and edible plant belonging to family Palmae. The fruits of this plant were used in traditional folk medicine due to its analgesia and anti-inflammatory activities. This study aimed to investigate the analgesic and anti-inflammatory properties an...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112349

    authors： Li F,Huo J,Zhuang Y,Xiao H,Wang W,Huang L

    更新日期：2020-02-10 00:00:00

  • Hydroalcoholic extract of Pfaffia glomerata alters the organization of the seminiferous tubules by modulating the oxidative state and the microstructural reorganization of the mice testes.

    abstract：ETHNOPHARMACOLOGICAL USAGES:Leaves and roots of Pfaffia glomerata areused as aphrodisiacs, tranquilizers and antirheumatics. Due to the lack of experimental scientific data, studies are necessary to identify its medicinal properties. AIMS:The present study aimed to evaluate the effect of hydroalcoholic root extract of...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.12.047

    authors： Dias FCR,Martins ALP,de Melo FCSA,Cupertino MDC,Gomes MLM,de Oliveira JM,Damasceno EM,Silva J,Otoni WC,da Matta SLP

    更新日期：2019-04-06 00:00:00

  • Investigation of antihypertensive mechanism of garlic in 2K1C hypertensive rat.

    abstract：:This study sought to examine the antihypertensive mechanism of garlic in two-kidney-one-clip (2K1C) hypertensive rat. In this study, the effect of garlic on serum and tissue including: aorta, heart, kidney, lung as well as circulatory (serum) ACE activity in 2K1C rats were examined. Four groups of rats were selected: ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00080-1

    authors： Sharifi AM,Darabi R,Akbarloo N

    更新日期：2003-06-01 00:00:00

  • Terminalia catappa L. infusion accelerates the healing process of gastric ischemia-reperfusion injury in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Terminalia catappa L. (Combretaceae), known as "amendoeira da praia" in Brazil, has been recognized as a medicinal plant in folk medicine for the treatment of gastrointestinal disorders and other inflammatory conditions. The present study aimed to investigate the preventive and healing ef...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112793

    authors： Ohara R,Périco LL,Rodrigues VP,Bueno G,Zanatta AC,Campaner Dos Santos L,Vilegas W,Constatino FB,Justulin LA,Hiruma-Lima CA

    更新日期：2020-06-28 00:00:00

  • The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal.

    abstract：:Essential oil, ethanolic extract and decoction of 10 plant species from interior Portugal were analyzed for their activity towards acetylcholinesterase (AChE) enzyme and their antioxidant activity. Of these, Melissa officinalis, Paronychia argentea, Sanguisorba minor, Hypericum undulatum and Malva silvestris are used ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.04.010

    authors： Ferreira A,Proença C,Serralheiro ML,Araújo ME

    更新日期：2006-11-03 00:00:00

  • Paeonia lactiflora extract suppresses cisplatin-induced muscle wasting via downregulation of muscle-specific ubiquitin E3 ligases, NF-κB signaling, and cytokine levels.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The dried root of Paeonia lactiflora Pall. (Radix Paeoniae) has been traditionally used to treat various inflammatory diseases in many Asian countries. AIM OF THE STUDY:Cisplatin is a broad-spectrum anticancer drug used in diverse types of cancer. However, muscle wasting is a common side...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113403

    authors： Jang J,Lee H,Song J,Bae T,Park M,Kwon YV,Lee D,Yoon Y

    更新日期：2021-02-10 00:00:00

  • Anti-osteoporosis activity of Cibotium barometz extract on ovariectomy-induced bone loss in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Recent research has confirmed that Cibotium barometz could inhibits osteoclast formation with no affect on BMM cell viability. However, the influence of Cibotium barometz on osteoporosis in animals is relatively unknown. The purpose of this study is to systemically investigate the effects...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.07.017

    authors： Zhao X,Wu ZX,Zhang Y,Yan YB,He Q,Cao PC,Lei W

    更新日期：2011-10-11 00:00:00

  • Effect of total flavonoids from the seeds of Astragali complanati on natural killer cell function.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The seeds of Astragalus complanatus R.Br. (AC), a traditional Chinese medicine, have been extensively used for clinical treatment of liver and kidney complaints and tumors for more than a thousand years. It was believed that AC is warm and sweet in the most authoritative medical book of A...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.07.017

    authors： Han R,Wu WQ,Wu XP,Liu CY

    更新日期：2015-09-15 00:00:00

  • Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The African continent is home to a large number of higher plant species used over centuries for many applications, which include treating and managing diseases such as HIV. Due to the overwhelming prevalence and incidence rates of HIV, especially in sub-Saharan Africa, it is necessary to ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2017.08.005

    authors： Prinsloo G,Marokane CK,Street RA

    更新日期：2018-01-10 00:00:00

  • A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Licorice (Glycyrrhizae radix), the root of Glycyrrhiza uralensis Fisch. (Leguminosae), is mainly used to moderate the characteristics of toxic herbs in Traditional Chinese Medicine, which could be partly interpreted as detoxification. However, the underlying mechanism is still not fully e...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.12.043

    authors： Gong H,Zhang BK,Yan M,Fang PF,Li HD,Hu CP,Yang Y,Cao P,Jiang P,Fan XR

    更新日期：2015-03-13 00:00:00

  • Increase of ejaculatory capacity by systemic administration of the oquichpatli (Senecio cardiophyllus) aqueous crude extract in male rats.

    abstract：AIM OF THE STUDY:To analyse the pro-ejaculatory properties of the proverbial Mexican plant oquichpatli, Senecio cardiophyllus, in an animal model for the study of ejaculation in spinal and anaesthetised male rats. MATERIALS AND METHODS:The aqueous crude extract of Senecio cardiophyllus (at 0.4, 1.2 and 4 mg/kg) was i....

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.09.006

    authors： Carro-Juárez M,Alcazar C,Ballesteros-Polvo E,Villalobos-Peñalosa P

    更新日期：2009-12-10 00:00:00

  • Argentine folk medicine: genotoxic effects of Chenopodiaceae family.

    abstract：:Chenopodium ambrosioides L. and Chenopodium multifidum L. (Chenopodiaceae), common name: Paico, are medicinal plants. They are aromatic shrubs growing in South America. For centuries, they have been used due to its medicinal properties. However, there are few reports in literature about the genotoxic effects of these ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.08.043

    authors： Gadano AB,Gurni AA,Carballo MA

    更新日期：2006-01-16 00:00:00

  • Myorelaxant Activity of essential oil from Origanum majorana L. on rat and rabbit.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Origanum majorana L. (Lamiaceae) was usually used in Moroccan folk medicine to treat infantile colic and abdominal discomfort. MATERIALS AND METHODS:The essential oil from the aerial part of the dry Origanum majorana L. (EOOM) was obtained through hydro distillation and analyzed by gas c...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.08.036

    authors： Makrane H,Aziz M,Berrabah M,Mekhfi H,Ziyyat A,Bnouham M,Legssyer A,Elombo FK,Gressier B,Eto B

    更新日期：2019-01-10 00:00:00

  • Isolation of seselin from Clausena anisata (Rutaceae) leaves and its effects on the feeding and development of Lucilia cuprina larvae may explain its use in ethnoveterinary medicine.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The leaves of Clausena anisata are used traditionally to expel maggots from wounds of animals in Zimbabwe. We have previously proved in the laboratory that the plant certainly affects the behaviour and growth of blowfly larvae. The objective of this study was to isolate and identify the a...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.09.037

    authors： Mukandiwa L,Ahmed A,Eloff JN,Naidoo V

    更新日期：2013-12-12 00:00:00

  • Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Hyptis martiusii (Lamiaceae), popularly known as "cidreira-do-mato" or "cidreira-brava", grows in abundance in the Northeast region of Brazil, where its leaves are traditionally used in folk medicine in the treatment of intestinal and stomach diseases. The aim of this study was to charact...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.07.005

    authors： Caldas GF,do Amaral Costa IM,da Silva JB,da Nóbrega RF,Rodrigues FF,da Costa JG,Wanderley AG

    更新日期：2011-09-01 00:00:00

  • Nrf-2 mediated heme oxygenase-1 activation contributes to the anti-inflammatory and renal protective effects of Ginkgo biloba extract in diabetic nephropathy.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ginkgo biloba extract (GbE) is derived from a medicinal plant and suggested as a treatment for diabetic nephropathy (DN), but the mechanism was not clarified. AIM OF STUDY:The present study investigated whether GbE prevented DN via activation of heme oxygenase (HO)-1. MATERIALS AND METH...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113474

    authors： Chang TT,Chen YA,Li SY,Chen JW

    更新日期：2021-02-10 00:00:00

  • Evaluation of Senegalese plants used in malaria treatment: focus on Chrozophora senegalensis.

    abstract：:An ethnobotanical study was conducted in the Dakar area of Senegal to investigate the species used in the treatment of malaria. Seven plants are principally used: Cissampelos mucronata, Maytenus senegalensis, Terminalia macroptera, Bidens engleri, Ceratotheca sesamoides, Chrozophora senegalensis and Mitracarpus scaber...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.10.033

    authors： Benoit-Vical F,Soh PN,Saléry M,Harguem L,Poupat C,Nongonierma R

    更新日期：2008-02-28 00:00:00

  • Rokumi-jio-gan-containing prescriptions regulate oxidative stress through improving dyslipidemia in a subtotal nephrectomized rat model.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Rokumi-jio-gan-containing prescriptions, traditional medicine, are widely used to treat renal dysfunction in Japan. AIM OF THE STUDY:The present study was conducted to examine whether two Rokumi-jio-gan-containing prescriptions (Hachimi-jio-gan and Bakumi-jio-gan) have an ameliorative ef...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.04.036

    authors： Park CH,Lee SL,Noh JS,Yokozawa T

    更新日期：2013-07-09 00:00:00

  • O-prenylated flavonoid, an antidiabetes constituent in Melicope lunu-ankenda.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Melicope lunu-ankenda leaves are used to treat diabetes in folklore medicinal practices in India and Malaysia. Here we report the isolation of an O-prenylated flavonoid (3,5,4'-trihydroxy-8,3'-dimethoxy-7-(3-methylbut-2-enoxy)flavone; OPF) from the leaves of M. lunu-ankenda and its antidi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.03.060

    authors： George S,Ajikumaran Nair S,Johnson AJ,Venkataraman R,Baby S

    更新日期：2015-06-20 00:00:00

  • Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract.

    abstract：:The aqueous extract of the tuber of Smilax china L., popularly known in China as "jin gang ten", was tested for its anti-inflammatory activities in rats by egg-albumin-induced edema and anti-nociceptive effects in mice using hot-plate test and acetic acid-induced abdominal constriction test, respectively. The aqueous ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.08.004

    authors： Shu XS,Gao ZH,Yang XL

    更新日期：2006-02-20 00:00:00