当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Cajanus cajan Linn. (Leguminosae) prevents alcohol-induced rat liver damage and augments cytoprotective function.

Cajanus cajan Linn. (Leguminosae) prevents alcohol-induced rat liver damage and augments cytoprotective function.

Abstract：

AIM OF THE STUDY:Cajanus cajan Linn. (Leguminosae) is a nontoxic edible herb, widely used in Indian folk medicine for the prevention of various liver disorders. In the present study we have demonstrated that methanol-aqueous fraction (MAF2) of Cajanus cajan leaf extract could prevent the chronically treated alcohol induced rat liver damage. MATERIALS AND METHODS:Chronic doses of alcohol (3.7 g/ kg) orally administered to rats for 28 days and liver function marker enzymes such as GPT, GOT, ALP and anti-oxidant enzyme activities were determined. Effect of MAF2 at a dose of 50mg/kg body weight on alcohol treated rats was noted. RESULTS:Alcohol effected significant increase in liver marker enzyme activities and reduced the activities of anti-oxidant enzymes. Co-administration of MAF2 reversed the liver damage due to alcohol; it decreased the activities of liver marker enzymes and augmented antioxidant enzyme activities. We also demonstrate significant decrease of the phase II detoxifying enzyme, UDP-glucuronosyl transferase (UGT) activity along with a three- and two-fold decrease of UGT2B gene and protein expression respectively. MAF2 co-administration normalized UGT activity and revived the expression of UGT2B with a concomitant expression and nuclear translocation of Nrf2, a transcription factor that regulates the expression of many cytoprotective genes. CONCLUSION:Cajanus cajan extract therefore shows a promise in therapeutic use in alcohol induced liver dysfunction.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Kundu R,Dasgupta S,Biswas A,Bhattacharya A,Pal BC,Bandyopadhyay D,Bhattacharya S,Bhattacharya S

doi

10.1016/j.jep.2008.05.010

subject

Has Abstract

pub_date

2008-08-13 00:00:00

pages

440-7

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(08)00255-9

journal_volume

118

pub_type

杂志文章

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