Abstract：
AIM:To validate plant species for hypoglycaemic activity. MATERIALS AND METHODS:Four plants were investigated for hypoglycaemic activity by evaluating inhibiting effects on carbohydrate-hydrolising enzymes: alpha-glucosidase and alpha-amylase. Acetone plant extracts were screened against C2C12 myocytes, 3T3-L1 preadipocytes and Chang liver cells by measuring glucose uptake. Cytotoxicity was done in preadipocytes and hepatocytes. RESULTS:Extract of Euclea undulata rootbark exhibited highest activity, displaying a glucose uptake of 162.2% by Chang liver cells at 50 microg/ml. An inhibition concentration of 50% for Euclea undulata was found to be 49.95 microg/ml for alpha-glucosidase and 2.8 microg/ml for alpha-amylase. No cytotoxicity was recorded for Euclea undulata, while Schkuhria pinnata and Elaeodendron transvaalense exhibited cytotoxicity at 12.5 microg/ml. Alpha-glucosidase and alpha-amylase assays showed inhibitory activity on enzymes for three plant extracts. CONCLUSION:Euclea undulata, Schkuhria pinnata and Elaeodendron transvaalense showed in vitro hypoglycaemic activity. Schkuhria pinnata and Elaeodendron transvaalense indicated cytotoxicity on 3T3-L1 preadipocytes and Chang liver cells. Euclea undulata, Pteronia divaricata and Elaeodendron transvaalense inhibited alpha-glucosidase and alpha-amylase enzymes. ETHNOPHARMACOLOGICAL RELEVANCE:Screening of plant extracts scientifically validated traditional use of Euclea undulata for treatment of diabetes. Cytotoxicity results revealed that acetone extracts of Schkuhria pinnata and Elaeodendron transvaalense are toxic and raise concern for chronic use.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Deutschländer MS,van de Venter M,Roux S,Louw J,Lall Ndoi
10.1016/j.jep.2009.04.052subject
Has Abstractpub_date
2009-07-30 00:00:00pages
619-24issue
3eissn
0378-8741issn
1872-7573pii
S0378-8741(09)00276-1journal_volume
124pub_type
杂志文章abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Qing Dai, a famous traditional Chinese medicine (TCM), is prepared by a traditional fermentation process with the aerial part of Strobilanthes cusia. Currently, this TCM could treat various clinical inflammatory diseases, such as ulcerative colitis and psoriasis, however, the bioactive co...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.112772
更新日期：2020-06-12 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Argentinean medicinal plants such as Larrea divaricata Cav., Larrea cuneifolia Cav., Larrea nitida Cav., Zuccagnia punctata Cav. and Tetraglochin andina Ciald. are used alone and in combination in traditional medicine by inhabitants from northwestern Argentina to solve mycosis, vaginal in...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.112642
更新日期：2020-05-10 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Kratom (Mitragyna speciosa Korth.) from the Rubiaceae family is an indigenous tropical medicinal tree of Southeast Asia. Kratom leaves have been used for decades in Malaysia and Thailand in traditional context for its perceived vast medicinal value, and as a mild stimulant among manual la...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2017.12.017
更新日期：2018-03-25 00:00:00
abstract：:The effect of the butanol extract of Zizyphus spina-christi (L.), Willd (Rhamnaceae) leaves and its major saponin glycoside, christinin-A, on the serum glucose and insulin levels was studied in non-diabetic control, type-I (insulin-dependent) and type-II (non-insulin-dependent) diabetic rats. Pretreatment either with ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2005.04.007
更新日期：2005-10-03 00:00:00
abstract：:The feeding of a fish extract, prepared by extracting whole fish with 80% ethanol, prevented abdominal, thoracic aorta and coronary atheroma in cholesterol-fed rabbits. Daily fish extract feeding reduced serum cholesterol and LDL-cholesterol levels by 41.8 and 38.0%, respectively. In addition, triglyceride levels were...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(94)90058-2
更新日期：1994-01-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In Togo, many persons still rely on plants for healing, however very little is known about the medicinal practices of the indigenous people. The present study aimed to document the medicinal plant utilization for the management of liver diseases in the Maritime region of the country. MET...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2015.12.051
更新日期：2016-04-02 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Tetrastigma hemsleyanum Diels et Gilg, known as Sanyeqing in China, was an extensively used folk Chinese herbal medicine. This plant had been validated to be highly effective for treating high fever, pneumonia, hepatitis, gastritis, cervicitis, lymphatic tuberculosis, septicemia, and vira...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2021.113836
更新日期：2021-01-16 00:00:00
abstract：:Comparative studies of the effects of tetrandrine (TET) and fangchinoline (FAN), two major components of the Radix of Stephannia tetrandrae, on vasodilations and on calcium movement in vascular smooth muscle, and studies of hypotensive effects on stroke-prone spontaneously hypertensive rats (SHRSP) were performed in t...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(97)00092-5
更新日期：1997-10-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Naoxintong (NXT), a renowned traditional Chinese medicine in China, has been used for the treatment of acute and chronic cardio-cerebrovascular diseases in clinic for more than 20 years. AIM OF THE STUDY:To evaluate the potential neuroprotective effect of NXT against ischemia reperfusion...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2016.02.022
更新日期：2016-04-22 00:00:00
abstract：:The effect of Indian herbs namely, Asparagus racemosus, Tinospora cordifolia, Withania somnifera and Picrorhiza kurrooa on the functions of macrophages obtained from mice treated with the carcinogen ochratoxin A (OTA) was investigated. The chemotactic activity of murine macrophages was significantly decreased by 17 we...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(97)00072-x
更新日期：1997-09-01 00:00:00
abstract：:The aqueous and alcoholic extracts of Trigonella foenum-graecum leaf were tested for hypoglycaemic activity in normal and alloxan-diabetic rats. Graded amounts (0.06, 0.2, 0.5, 1 g/kg, i.p. and 1, 2, 8 g/kg, p.o.) of the aqueous extract of Trigonella foenum-graecum leaf when given to both normal and alloxan-diabetic r...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(97)00101-3
更新日期：1997-11-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Nyctanthes arbor-tristis (Oleaceae) is a mythological plant; has high medicinal values in Ayurveda. The popular medicinal use of this plant are anti-helminthic and anti-pyretic besides its use as a laxative, in rheumatism, skin ailments and as a sedative. Vitally, the natives plant it in ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2013.01.024
更新日期：2013-04-19 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as "Marcela" or "Macela". The infusion obtained from inflorescences of this plant is widely used in Brazilian folk medicine as an antispasmodic, anti-inflammatory, hypoglycemic, and hypocholesterolemi...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.05.014
更新日期：2010-07-20 00:00:00
abstract：:Extracts from Helichrysum aureonitens are used topically by the indigenous people of South Africa against infections. The antimicrobial activity-guided fractionation by bioautography of the acetone extract from the aerial parts of H. aureonitens led to the isolation of 3,5,7-trihydroxyflavone (galangin). Evaluation of...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(97)00065-2
更新日期：1997-08-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Oryeongsan (ORS, Wulingsan) has been reported to possess renal protective effects from renal diseases such as diabetes-induced renal damage, and nephrocalcinosis. AIM OF THE STUDY:This study was conducted to evaluate the quantitative analysis and the inhibitory effect of ORS on hypertoni...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2016.03.030
更新日期：2016-06-05 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants from the Caatinga, a Brazilian xeric shrubland, are used in folk medicine to treat infections. These ethnopharmacological data can contribute to obtaining new antimicrobial/antibiofilm extracts and natural product prototypes for the development of new drugs. The aim of th...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2011.05.030
更新日期：2011-09-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Zataria multiflora is an iranian valuable traditional plants, called Avishan Shirazi in Persian language used to reduce inflammation, spasm, pain, and cancer symptoms. Zataria essential oil (ZEO) is one of the essential oils possessing broad biological activities. AIM OF THE STUDY:The ai...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.112865
更新日期：2020-07-15 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The lack of ethnoveterinary surveys in Brazil, especially in the Amazon region, results in losses in the veterinary phytopharmacology field and in scientific documentation of the cultural traditions of plant use in the treatment of animal diseases. AIM OF THE STUDY:To catalog, analyze an...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2012.09.018
更新日期：2012-11-21 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Callicarpa L. (Verbenaceae) has been used for centuries in Traditional Chinese Medicine (TCM) for the prevention and treatment of a wide number of health disorders such as inflammation, rheumatism, hematuria, fracture, hematemesis, menoxenia, gastrointestinal bleeding, scrofula, etc. AIM...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2012.12.051
更新日期：2013-03-27 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Worldwide, one of the drivers of substitution and adulteration is the cost of the natural resources (plants, animals, fungi) that are ingredients of traditional medicines. Relatively few studies have been done that link prices of traditional medicine ingredients to what drives changes in ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2018.10.010
更新日期：2019-01-30 00:00:00
abstract：AIMS OF THE STUDY:This study was to investigate the gastrokinetic activity of Morinda citrifolia aqueous fruit extract (AFE) in human subjects by examining the GI absorption of ranitidine, a putative indicator of GI motility and to elucidate its possible gastrokinetic mechanism of action in rats. MATERIALS AND METHODS...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jep.2012.04.044
更新日期：2012-07-13 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Pfaffia glomerata roots are widely used in Brazil to treat various pathological conditions, particularly psychological disorders. 20-hydroxyecdysone, a phytosteroid present in the plant, can promote greater body resistance against exogenous and endogenous stressors. The objective of this ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.113599
更新日期：2021-03-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Korean red ginseng (KRG) has been shown to possess various biological activities including anti-inflammatory properties. AIM OF THE STUDY:We aimed to investigate the effects and mechanism of KRG on the prevention of atopic dermatitis (AD) using a mouse model. MATERIALS AND METHODS:The e...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2012.11.006
更新日期：2013-01-09 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The present study has indicated phytochemical composition, distribution and ethno-medicinal uses of Arnebia euchroma (Royle) I.M. Johnst, which is commonly known as "Ratanjot" in the Indian subcontinent. It has widely been used in the traditional systems of the Unani, Ayurvedic and Chines...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2021.113896
更新日期：2021-01-29 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Polygonum multiflorum Thunb (Heshouwu, HSW) is commonly used in clinical medicine, while the hepatotoxicities of HSW are reported increasingly in recent years. Currently, researchers have demonstrated an essential role of Bile Acids (BAs) in liver diseases. The occurrence of hepatotoxicit...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2018.12.007
更新日期：2019-05-10 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Aristolochia ringens Vahl. (Aristolochiaceae) is used traditionally in Nigeria for managing a number of ailments including gastrointestinal disturbances, rheumatoid arthritis, pile, insomnia, oedema, and snake bite venom. Some studies in our laboratory have demonstrated a scientific justi...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2019.112150
更新日期：2019-11-15 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Euphorbia humifusa Willd. (EH) is an important traditional Chinese medicine that has commonly been used for treating bacillary dysentery and enteritis in many Asian countries for thousands of years. EH has a wide variety of pharmacological actions such as antioxidant, hypotensive, and hyp...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2013.05.025
更新日期：2013-07-09 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Lizhong Decoction (LZD) is a classical prescription firstly recorded in "Shanghan Lun". It has been used to clinically treat ulcerative colitis (UC) for thousands of years. However, its mechanism is not clear up to now. AIM OF THE STUDY:The goal of this study was to assess the ameliorati...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.112919
更新日期：2020-09-15 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Caesalpinia pyramidalis Tul. (Fabaceae), known as "catingueira", is an endemic tree of the Northeast region of Brazil. This plant, mainly inner bark and flowers, has been used in traditional medicine to treat gastritis, heartburn, indigestion, stomachache, dysenteries, and diarrheas. MAT...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2015.03.054
更新日期：2015-06-20 00:00:00
abstract：:Pteleopsis suberosa Engl. et Diels was used in the traditional medicine of Mali for the treatment of gastric and duodenal ulcers. In an ethnopharmacological approach, Pteleopsis suberosa extracts of the stem bark were investigated for antiulcer and antibacterial activity against Helicobacter pylori standard strains an...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/s0378-8741(97)00109-8
更新日期：1998-01-01 00:00:00
