Antifungal, anti-inflammatory and antioxidant activity of bi-herbal mixtures with medicinal plants from Argentinean highlands.


ETHNOPHARMACOLOGICAL RELEVANCE:Argentinean medicinal plants such as Larrea divaricata Cav., Larrea cuneifolia Cav., Larrea nitida Cav., Zuccagnia punctata Cav. and Tetraglochin andina Ciald. are used alone and in combination in traditional medicine by inhabitants from northwestern Argentina to solve mycosis, vaginal infections, gastrointestinal, respiratory, and inflammatory processes. AIM OF THE STUDY:To assess the effect of interactions between hydroalcoholic extracts of these five species of medicinal plants against yeast strains isolated from vaginal infections, select the most active mixtures and evaluate anti-inflammatory and antioxidant activities. MATERIAL AND METHODS:Synergy between the plant extracts was studied by using a broth microdilution assay by means of the checkerboard method against Saccharomyces cerevisiae, Candida albicans, and non albicans strains. The inhibitory effect on lipoxygenase and the antioxidant capacity in cell-free and cell systems were studied. The chemical profile was evaluated by qualitative and quantitative screening, whereas chemical markers were quantified by HPLC-DAD. RESULTS:A synergistic antifungal effect was observed in some binary combinations. Z. punctata/L. divaricata, Z. punctata/L. cuneifolia, and Z. punctata/L. nitida were the most active mixtures. Nordihydroguaiaretic acid and 2',4'-dihydroxychalcone, two antifungal compounds, present in these extracts, were identified and quantified by HPLC-DAD. Both single extracts and bi-herbal mixtures showed antioxidant activity (in cellular and in cell-free systems) and were active on pro-inflammatory enzymes (LOX). CONCLUSIONS:Our results indicated that the most active combinations of these species extracts could be useful in the treatment of vaginal infectious diseases caused by Saccharomyces cerevisiae and Candida spp. strains and in associated oxidative and inflammatory processes, supporting its traditional use. In addition, the results highlighted the phyto-therapeutic potential of total phytochemical compounds present in these medicinal plants.


J Ethnopharmacol


Moreno MA,Zampini IC,Isla MI




Has Abstract


2020-05-10 00:00:00












  • Investigation on the morphological protective effect of 5-hydroxymethylfurfural extracted from wine-processed Fructus corni on human L02 hepatocytes.

    abstract:AIM:To determine the mode of action of 5-hydroxymethylfurfural (5-HMF) extracted from wine-processed Fructus corni on hepatoprotective activities, the effects of 5-HMF on H(2)O(2)-induced human L02 hepatocytes injury was examined. MTHODS: Hepatocytes L02 injured by H(2)O(2) was treated by 5-HMF. The morphological chang...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Wang MY,Zhao FM,Peng HY,Lou CH,Li Y,Ding X,Yu XY,Yang GM,Xu DQ,Jiang LH,Zhang X,Ye LH,Cai BC

    更新日期:2010-07-20 00:00:00

  • Yan-Hou-Qing formula attenuates allergic airway inflammation via up-regulation of Treg and suppressing Th2 responses in Ovalbumin-induced asthmatic mice.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Yan-Hou-Qing (YHQ), a Chinese medicine formula containing fourteen kinds of materials, has been designed for pharyngitis and cough treatment in Oriental medicine. In the present study, the anti-allergic effects and underlying mechanisms of YHQ in inhibition of airway hyper responsiveness ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Cheng BH,Hu TY,Mo LH,Ma L,Hu WH,Li YS,Liu ZQ,Qiu SQ

    更新日期:2019-03-01 00:00:00

  • Holistic quality evaluation of Qingwen Baidu Decoction and its anti-inflammatory effects.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Qingwen Baidu Decoction (QBD), a famous traditional Chinese medicine prescription with heat-clearing and detoxifying efficacies, is widely used in the treatment of inflammatory diseases. However, due to lack of holistic quality evaluation research, the further study on the detailed molecu...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Zheng Y,Liu S,Fan C,Zeng H,Huang H,Tian C,Lu Z,Cao H,Liu J,Yu L

    更新日期:2020-12-05 00:00:00

  • Ganoderma lucidum spore oil induces apoptosis of breast cancer cells in vitro and in vivo by activating caspase-3 and caspase-9.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The mushroom Ganoderma lucidum (G. lucidum) is a traditional Chinese medicine reported to have a variety of pharmacological properties, including anti-cancer activity. G. lucidum spore oil (GLSO) is a lipid substance extracted from sporoderm-broken spore of G. lucidum. However, the effect...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Jiao C,Chen W,Tan X,Liang H,Li J,Yun H,He C,Chen J,Ma X,Xie Y,Yang BB

    更新日期:2020-01-30 00:00:00

  • M3 muscarinic receptor- and Ca2+ influx-mediated muscle contractions induced by croton oil in isolated rabbit jejunum.

    abstract:AIM OF STUDY:Croton oil is the fruit oil of Croton tiglium L., which is well known in folk medicine for the treatment of gastrointestinal (GI) diseases, including constipation, abdominal pain, peptic ulcer, and intestinal inflammation for a long period. This study was to investigate the pharmacological effect of croton...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Hu J,Gao WY,Gao Y,Ling NS,Huang LQ,Liu CX

    更新日期:2010-06-16 00:00:00

  • The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa.

    abstract::The aqueous extract of Nigella sativa (N. sativa) was investigated for anti-inflammatory, analgesic and antipyretic activities in animal models. The extract has an anti-inflammatory effect demonstrated by its inhibitory effects on Carrageenan induced paw edema. It also produced significant increase in the hot plate re...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Al-Ghamdi MS

    更新日期:2001-06-01 00:00:00

  • Effects of Red Ginseng extract on allergic reactions to food in Balb/c mice.

    abstract:AIM OF THE STUDY:Red Ginseng roots (Panax ginseng C.A. Meyer) have traditionally been thought to have anti-allergic effects, but their influence on food-induced allergic responses is unclear. MATERIALS AND METHODS:This study examined the effects of a Red Ginseng extract on an ova-albumin (OVA)-evoked allergic reaction...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Sumiyoshi M,Sakanaka M,Kimura Y

    更新日期:2010-10-28 00:00:00

  • Ethnopharmacological survey of medicinal plants used in Daraa-Tafilalet region (Province of Errachidia), Morocco.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:We carried out an ethnobotanical survey in Tafilalet region. This region is classified by the UNESCO as a reserve of biosphere and represents an important area with important knowledge of traditional medicine, especially the use of medicinal plants for human healthcare. Furthermore, the g...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Eddouks M,Ajebli M,Hebi M

    更新日期:2017-02-23 00:00:00

  • Saussurea costus: botanical, chemical and pharmacological review of an ayurvedic medicinal plant.

    abstract::Saussurea costus (Falc.) Lipschitz, syn Saussurea lappa C.B. Clarke is a well known and important medicinal plant widely used in several indigenous systems of medicine for the treatment of various ailments, viz. asthma, inflammatory diseases, ulcer and stomach problems. Sesquiterpene lactones have been reported as the...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审


    authors: Pandey MM,Rastogi S,Rawat AK

    更新日期:2007-04-04 00:00:00

  • Gallesia integrifolia (Spreng.) Harms: In vitro and in vivo antibacterial activities and mode of action.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Gallesia integrifolia (Phytolaccaceae) is commonly known as "pau-d'alho" in Brazil or "garlic plant" due to the strong scent of garlic peculiar to all parts of the plant. The bark decoction is used for the treatment of microbial infections among other diseases by different ethnic groups i...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Arunachalam K,Ascêncio SD,Soares IM,Souza Aguiar RW,da Silva LI,de Oliveira RG,Balogun SO,de Oliveira Martins DT

    更新日期:2016-05-26 00:00:00

  • Medicinal plants of Guinea-Bissau: Therapeutic applications, ethnic diversity and knowledge transfer.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The rich flora of Guinea-Bissau, and the widespread use of medicinal plants for the treatment of various diseases, constitutes an important local healthcare resource with significant potential for research and development of phytomedicines. The goal of this study is to prepare a comprehen...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Catarino L,Havik PJ,Romeiras MM

    更新日期:2016-05-13 00:00:00

  • Antimicrobial potential of Glycyrrhiza glabra roots.

    abstract::The present study was aimed to investigate antimicrobial potential of Glycyrrhiza glabra roots. Antimycobacterial activity of Glycyrrhiza glabra was found at 500 microg/mL concentration. Bioactivity guided phytochemical analysis identified glabridin as potentially active against both Mycobacterium tuberculosis H(37)Ra...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Gupta VK,Fatima A,Faridi U,Negi AS,Shanker K,Kumar JK,Rahuja N,Luqman S,Sisodia BS,Saikia D,Darokar MP,Khanuja SP

    更新日期:2008-03-05 00:00:00

  • Uncovering potential of Indonesian medicinal plants on glucose uptake enhancement and lipid suppression in 3T3-L1 adipocytes.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:As obesity is a key factor in the development of type 2 diabetes, lowering lipid accumulation in adipose tissues is as important as increasing insulin sensitivity in diabetic patients. The selected plant extracts used in this screen have been traditionally used in Indonesian medicine for ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Lahrita L,Kato E,Kawabata J

    更新日期:2015-06-20 00:00:00

  • Investigation of some Hypericum species native to Southern of Brazil for antiviral activity.

    abstract::Three plant species, Hypericum connatum, Hypericum caprifoliatum, Hypericum polyanthemum (Guttiferae), growing in Southern of Brazil were chemically investigated and tested for their antiviral activity against feline immunodeficiency virus (FIV). The chemical analysis revealed the presence of polyphenolic compounds su...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Schmitt AC,Ravazzolo AP,von Poser GL

    更新日期:2001-10-01 00:00:00

  • Anti-diarrheal activity of (-)-epicatechin from Chiranthodendron pentadactylon Larreat: experimental and computational studies.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Chiranthodendron pentadactylon Larreat is frequently used in Mexican traditional medicine as well as in Guatemalan for several medicinal purposes, including their use in the control of diarrhea. AIM OF THE STUDY:This work was undertaken to obtain additional information that support the t...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Velázquez C,Correa-Basurto J,Garcia-Hernandez N,Barbosa E,Tesoro-Cruz E,Calzada S,Calzada F

    更新日期:2012-09-28 00:00:00

  • Salix caprea inhibits skin carcinogenesis in murine skin: inhibition of oxidative stress, ornithine decarboxylase activity and DNA synthesis.

    abstract::Chemoprevention of free radical-mediated diseases including cancer by natural products is an emerging discipline due to its wider applicability and acceptance. The present study deals with the chemopreventive effect of Salix caprea against phorbol ester-induced oxidative stress and tumor promotion in murine skin. In t...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Sultana S,Saleem M

    更新日期:2004-04-01 00:00:00

  • Larvicidal activity of extracts from Quercus lusitania var. infectoria galls (Oliv.).

    abstract::The present study indicates the efficacy of extracts and fractions of Quercus lusitania var. infectoria galls (Oliv.) as larvicidal agents and their possible use in biological control of Culex pipiens, the urban nuisance mosquito. Extracts and fractions were tested against second and fourth instar larvae. The LC(50) v...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Redwane A,Lazrek HB,Bouallam S,Markouk M,Amarouch H,Jana M

    更新日期:2002-02-01 00:00:00

  • Anna Pavala Sindhooram--an antiatherosclerotic Indian drug.

    abstract::The procedure for the preparation of Anna Pavala Sindhooram (APS), a drug based on the concepts of Indian medicine for the prevention and reversal of the atherosclerotic disease process is described in detail. The uniformity in the composition of samples of the drug obtained in 10 batches, prepared over a period of 5 ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Shanmugasundaram KR,Seethapathy PG,Shanmugasundaram ER

    更新日期:1983-05-01 00:00:00

  • Antihypertensive effect of Phragmanthera incana (Schum) Balle on NG-nitro-L-Arginine methyl ester (L-NAME) induced hypertensive rats.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Phragmanthera incana (Schum) Balle is a member of the African mistletoes that has been reported to be used in ethnomedicine for the treatment of hypertension. AIM:The aim of this study was to investigate the antihypertensive effect of Phragmanthera incana leaf ethanol extract (PILEE) in ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Adedapo ADA,Ajayi AM,Ekwunife NL,Falayi OO,Oyagbemi A,Omobowale TO,Adedapo AA

    更新日期:2020-07-15 00:00:00

  • Neuropharmacological screening of Diospyros mespiliformis in mice.

    abstract::The neuropharmacological activities of the aqueous extract of Diospyros mespiliformis stem bark were screened in mice. The extracts effect on pentobarbital-induced sleeping time, pentylenetetrazole induced seizure, spontaneous motor activity (SMA), exploratory behaviour, and rota-rod performance (motor coordination) w...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Adzu B,Amos S,Muazzam I,Inyang US,Gamaniel KS

    更新日期:2002-11-01 00:00:00

  • Chyawanprash: A review of therapeutic benefits as in authoritative texts and documented clinical literature.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Chyawanprash (CP), a traditional immune booster recipe, has a long history of ethnic origin, development, household preparation and usage. There are even mythological stories about the origin of this recipe including its nomenclature. In the last six decades, CP, because of entrepreneuria...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审


    authors: Narayana DB,Durg S,Manohar PR,Mahapatra A,Aramya AR

    更新日期:2017-02-02 00:00:00

  • Preclinical safety evaluation of the aqueous extract from Mangifera indica Linn. (Anacardiaceae): genotoxic, clastogenic and cytotoxic assessment in experimental models of genotoxicity in rats to predict potential human risks.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants widely used by the population contain significant concentrations of biologically active compounds and, although they have proven pharmacological properties, can cause DNA damage and develop fatal diseases. AIM OF THE STUDY:The present study aimed to evaluate the genotoxi...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Villas Boas GR,Rodrigues Lemos JM,de Oliveira MW,Dos Santos RC,Stefanello da Silveira AP,Bacha FB,Aguero Ito CN,Cornelius EB,Lima FB,Sachilarid Rodrigues AM,Costa NB,Bittencourt FF,Freitas de Lima F,Paes MM,Gubert P,Oesterr

    更新日期:2019-10-28 00:00:00

  • Effect of ME-3451-106, an aqueous extract of Stichaster striatus with inhibitory activity of voluntary alcohol intake, in genetically drinker rats: Isolation and identification of the active fraction.

    abstract::The aqueous extract obtained from Stichaster striatus Müller & Troschel (Asteroidea, Stichasteridae) has been shown to possess activity as an alcohol appetite inhibitor after oral administration in a rat model with a genetically established excessive appetite for alcohol (Wistar rats, lineage UChB). A significant decr...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Font M,Bilbeny N,Contreras S,Paeile C,García H

    更新日期:2006-04-21 00:00:00

  • Assessment of the effect of Maytenus ilicifolia (espinheira santa) extract on the labeling of red blood cells and plasma proteins with technetium-99m.

    abstract::We are trying to develop a model to assess properties of products utilized in popular medicine. Maytenus ilicifolia is used in herbal medicine. Red blood cells (RBC) labeled with technetium-99m (99mTc) are employed in nuclear medicine. This labeling procedure depends on a reducing agent and stannous chloride is used. ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: de Oliveira JF,Braga AC,de Oliveira MB,Avila AS,Caldeira-de-Araújo A,Cardoso VN,Bezerra RJ,Bernardo-Filho M

    更新日期:2000-09-01 00:00:00

  • Possible involvement of amine oxidase inhibition in the sympathetic activation induced by khat (Catha edulis) chewing in humans.

    abstract::The possibility that phenylalkylamines (cathinone and cathine) of khat, like amphetamines, are amine oxidase inhibitors with clinical significance is evaluated. Results show that khat chewing induces a significant increase in blood pressure, body temperature and urinary catecholamines in khat naive subjects. On the ot...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Nencini P,Amiconi G,Befani O,Abdullahi MA,Anania MC

    更新日期:1984-06-01 00:00:00

  • Inhibitory effect of jaceosidin isolated from Artemisiaargyi on the function of E6 and E7 oncoproteins of HPV 16.

    abstract::Jaceosidin (4',5,7-trihydroxy-3',6-dimethoxyflavone) was isolated from Artemisia argyi as a putative oncogene inhibitor. Jaceosidin inhibited binding between oncoprotein E6 of the human papillomavirus and the p53 tumor suppressor protein. In addition, jaceosidin inhibited binding between the E7 oncoprotein and the Rb ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Lee HG,Yu KA,Oh WK,Baeg TW,Oh HC,Ahn JS,Jang WC,Kim JW,Lim JS,Choe YK,Yoon DY

    更新日期:2005-04-26 00:00:00

  • Protective effects of organic acid component from Taraxacum mongolicum Hand.-Mazz. against LPS-induced inflammation: Regulating the TLR4/IKK/NF-κB signal pathway.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:TMHM is a type of Chinese medicine commonly used in medical practice and has multiple functions, including clearing heat, detoxification, reducing swelling, and tumor therapy. Previous research has demonstrated that the OAC of TMHM (TMHM-OAC) displays advantageous therapeutic action again...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Yang N,Dong Z,Tian G,Zhu M,Li C,Bu W,Chen J,Hou X,Liu Y,Wang G,Jia X,Di L,Feng L

    更新日期:2016-12-24 00:00:00

  • Antioxidant, antimicrobial and antiverotoxic potentials of extracts of Curtisia dentata.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:There is an increase in antimicrobial resistance and complexities arising from verotoxic related bacterial infections as well as rise in demand for application of natural antioxidants to combat oxidative damage by free radicals in many oxidative stress-mediated disease conditions such as ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Doughari JH,Ndakidemi PA,Human IS,Benade S

    更新日期:2012-06-14 00:00:00

  • Neuropharmacological activity of Solanum nigrum fruit.

    abstract::The ethanol extract of the fruit of Solanum nigrum L. (Solanaceae) was studied for its neuropharmacological properties on experimental animals. On intraperitoneal injection, the extract significantly prolonged pentobarbital-induced sleeping time, produced alteration in the general behavior pattern, reduced exploratory...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Perez RM,Perez JA,Garcia LM,Sossa H

    更新日期:1998-08-01 00:00:00

  • GJ-4 ameliorates memory impairment in focal cerebral ischemia/reperfusion of rats via inhibiting JAK2/STAT1-mediated neuroinflammation.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Gardenia jasminoides J. Ellis (Fructus Gardenia) is a traditional Chinese medicine with diverse pharmacological functions, such as anti-inflammation, anti-depression, as well as improvement of cognition and ischemia brain injury. GJ-4 is a natural extract from Gardenia jasminoides J. Elli...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Liu H,Zhang Z,Zang C,Wang L,Yang H,Sheng C,Shang J,Zhao Z,Yuan F,Yu Y,Yao X,Bao X,Zhang D

    更新日期:2021-03-01 00:00:00