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Effect of some Indian herbs on macrophage functions in ochratoxin A treated mice.

Abstract：

:The effect of Indian herbs namely, Asparagus racemosus, Tinospora cordifolia, Withania somnifera and Picrorhiza kurrooa on the functions of macrophages obtained from mice treated with the carcinogen ochratoxin A (OTA) was investigated. The chemotactic activity of murine macrophages was significantly decreased by 17 weeks of treatment with OTA compared with controls. Production of interleukin-1 (IL-1) and tumor necrosis factor (TNF) was also markedly reduced. Treatment with Asparagus racemosus, Tinospora cordifolia, Withania somnifera and Picrorhiza kurrooa significantly inhibited OTA-induced suppression of chemotactic activity and production of IL-1 and TNF-alpha by macropahges. Moreover, we found that Withania somnifera treated macrophage chemotaxis and that Asparagus racemosus induced excess production of TNF-alpha when compared with controls.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Dhuley JN

doi

10.1016/s0378-8741(97)00072-x

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

15-20

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(97)00072-X

journal_volume

58

pub_type

杂志文章

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