当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Investigation of Lepechinia graveolens for its antioxidant activity and phenolic composition.

Investigation of Lepechinia graveolens for its antioxidant activity and phenolic composition.

Abstract：

:A bioguided separation of Lepechinia graveolens (Reg.) Epling. (Lamiaceae) for antioxidant activity was carried out. The ethyl acetate fraction (EAF) from the methanolic extract was chromatographed on Sephadex LH-20 affording five active fractions. The radical scavenging activity of each fraction, as well as that of the isolated compounds, was tested using three different methods. The major isolated antioxidant compounds were identified as luteolin-7-O-glucuronide, rosmarinic acid, and rosmarinic acid methyl ester by means of 1H and 13C NMR and mass spectrometry. Twenty other minor phenolic compounds were determined by liquid chromatography-negative electrospray ionization tandem mass spectrometry. They included hydroxycinnamic acid derivatives, flavonoids and phenolic diterpenes. The major phenolic compound was found to be rosmarinic acid, which was quantitatively determined by high-performance liquid chromatography (HPLC)-diode array detector (DAD). The content of rosmarinic acid was 2.8% (referred to dry weight), this amount being around 30% of the total phenolic content (TPH) of the crude extract. It can be concluded that the antioxidant activity of Lepechinia graveolens was mainly due to rosmarinic acid, which allows this plant species to be considered as a potential new source of this well known natural antioxidant.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Parejo I,Caprai E,Bastida J,Viladomat F,Jáuregui O,Codina C

doi

10.1016/j.jep.2004.05.017

keywords:

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

175-84

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378874104002624

journal_volume

94

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Effect of salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cells.

    abstract：AIM OF THE STUDY:Salvianolic-acid B (SA-B) is an effective component of Radix Salviae miltiorrhizae for anti-hepatic fibrotic herbs. MAPK signaling pathway has been implicated in hepatic stellate cells (HSC) stimulated by TGF-(1. We have investigated the effect of SA-B on MAPK pathway in rat HSC. MATERIALS AND METHODS...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.05.026

    authors： Lv Z,Song Y,Xue D,Zhang W,Cheng Y,Xu L

    更新日期：2010-11-11 00:00:00

  • Bioguided identification of triterpenoids and neolignans as bioactive compounds from anti-infectious medicinal plants of the Taira Atacama's community (Calama, Chile).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Previous ethnobotanical surveys from the north Andean part of Chile, where different ethnic groups are co-existing, with the preeminence of Aymara and Atacama traditions, revealed an extensive domestic use of the local flora. In these communities, traditional medicinal uses are mainly rel...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.10.029

    authors： Ortiz S,Lecsö-Bornet M,Bonnal C,Houze S,Michel S,Grougnet R,Boutefnouchet S

    更新日期：2019-03-01 00:00:00

  • Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The African continent is home to a large number of higher plant species used over centuries for many applications, which include treating and managing diseases such as HIV. Due to the overwhelming prevalence and incidence rates of HIV, especially in sub-Saharan Africa, it is necessary to ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2017.08.005

    authors： Prinsloo G,Marokane CK,Street RA

    更新日期：2018-01-10 00:00:00

  • Hepatoprotective effect of total flavonoids of Mallotus apelta (Lour.) Muell.Arg. leaf against carbon tetrachloride-induced liver fibrosis in rats via modulation of TGF-β1/Smad and NF-κB signaling pathways.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The Mallotus apelta (Lour.) Muell.Arg. is a well-known traditional Chinese medicine (TCM) used for anti-inflammatory, hemostasis and chronic hepatitis. AIM:The purpose of this study was to explore the antifibrotic effect of total flavonoids of Mallotus apelta leaf (TFM) and its potential...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112714

    authors： Zhang B,Lai L,Tan Y,Liang Q,Bai F,Mai W,Huang Q,Ye Y

    更新日期：2020-05-23 00:00:00

  • Preliminary evaluation: the effects of Aloe ferox Miller and Aloe arborescens Miller on wound healing.

    abstract：AIM OF THE STUDY:Genus Aloe has been traditionally utilized for medicinal purpose for decades. Compared with Aloe vera gel, the qualitative assessment for the therapeutic effects of the other two Aloe species, Aloe ferox Miller and Aloe arborescens Miller, for their topical wound healing was less addressed. Therefore, ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.08.008

    authors： Jia Y,Zhao G,Jia J

    更新日期：2008-11-20 00:00:00

  • Hemostasis and uterine contraction promoting effect of the extract from drugs in the Zi-Yin-Tiao-Jing granule, a traditional Chinese compound preparation.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Zi-Yin-Tiao-Jing granule (ZG) is a traditional Chinese medicine compound preparation for perimenopausal dysfunctional uterine bleeding. It is made from 9 Chinese crude drugs based on a modified traditional Chinese prescription recorded in Fu Qingzhu Nvke as Guben Zhibeng Tang. AIM OF THE...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.09.035

    authors： Tang Q,Yang S,Tong J,Li X,Wu J,Wang S,Zhang J,Chen Y,Xu X

    更新日期：2018-01-30 00:00:00

  • Cupressus lusitanica (Cupressaceae) leaf extract induces apoptosis in cancer cells.

    abstract：:A crude ethanolic extract of Cupressus lusitanica Mill. leaves demonstrate cytotoxicity in a panel of cancer cell lines. Cell death was due to apoptosis, as assessed by morphologic features (chromatin condensation and apoptotic bodies formation) and specific DNA fragmentation detected by in situ end-labeling of DNA br...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00417-2

    authors： Lopéz L,Villavicencio MA,Albores A,Martínez M,de la Garza J,Meléndez-Zajgla J,Maldonado V

    更新日期：2002-05-01 00:00:00

  • Antimutagenicity and induction of antioxidant defense by flavonoid rich extract of Myrcia bella Cambess. in normal and tumor gastric cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The Brazilian "Cerrado" is an important source of natural products, such as Myrcia bella Cambess (MB, also known as "mercurinho"). MB leaves are popularly used for the treatment of diabetes and gastrointestinal disorders; however, only its hypoglycemic activity has been experimentally des...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.11.003

    authors： Serpeloni JM,Specian AF,Ribeiro DL,Tuttis K,Vilegas W,Martínez-López W,Dokkedal AL,Saldanha LL,Cólus IM,Varanda EA

    更新日期：2015-12-24 00:00:00

  • A novel approach using metabolomics coupled with hematological and biochemical parameters to explain the enriching-blood effect and mechanism of unprocessed Angelica sinensis and its 4 kinds of processed products.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Angelica sinensis (AS), root of Angelica sinensis (Oliv.) Diels, an important kind of Chinese traditional herbal medicine, has been used for women to enrich the blood for thousands of years. It is mainly distributed in Gansu province of China. According to Traditional Chinese medicine usa...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.09.028

    authors： Ji P,Wei Y,Hua Y,Zhang X,Yao W,Ma Q,Yuan Z,Wen Y,Yang C

    更新日期：2018-01-30 00:00:00

  • Traditional plants used for medicinal purposes by local communities around the Northern sector of Kibale National Park, Uganda.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The study was done to establish medicinal plants used in the treatment of various diseases by the people in the Northern sector of Kibale National Park in western Uganda. It was also aimed at establishing the plant parts used and the mode of preparation of remedies. These plants create a ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.04.044

    authors： Namukobe J,Kasenene JM,Kiremire BT,Byamukama R,Kamatenesi-Mugisha M,Krief S,Dumontet V,Kabasa JD

    更新日期：2011-06-14 00:00:00

  • Polygonum multiflorum: Recent Updates on Newly isolated Compounds, Potential Hepatotoxic Compounds and Their Mechanisms.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Polygonum multiflorum Thunb.(PM), (known as Heshouwu () in China) is one of the most important and well mentioned Chinese medicinal herbs in the literature for its use in blackening hair, nourishing liver and kidney, anti-aging, anti-hyperlipidemia, antioxidant, anti-inflammatory, antican...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2021.113864

    authors： Teka T,Wang L,Gao J,Mou J,Pan G,Yu H,Gao X,Han L

    更新日期：2021-01-21 00:00:00

  • Investigations on Dieffenbachia amoena Gentil. I: Endocrine effects and contraceptive activity.

    abstract：:Contraceptive activity and the correlated endocrine alterations of an aqueous extract of the leaves of Dieffenbachia amoena were investigated. In female Wistar rats the extract, given for 4 days during the estrous cycle, induced significant variations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), pr...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(84)90059-x

    authors： Costa de Pasquale R,Ragusa S,Circosta C,Forestieri AM

    更新日期：1984-12-01 00:00:00

  • Screening for cytotoxic activity of plants used in traditional medicine.

    abstract：:A total of 260 extracts have been prepared from 75 medicinal plant species collected in Africa, Panama and Mauritius. Three different concentrations of each extract have been screened in vitro for cytotoxic activity using a colorimetric assay to determine cell survival of human colon carcinoma Co115 cells. Fifteen pla...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(88)90006-2

    authors： Chapuis JC,Sordat B,Hostettmann K

    更新日期：1988-07-01 00:00:00

  • Diuretic, natriuretic and hypotensive effects produced by Allium sativum (garlic) in anaesthetized dogs.

    abstract：:Gastric administration of encapsuled garlic powder to anaesthetized dogs induced dose-dependent (2.5 to 15 mg/kg) natriuretic and diuretic responses which reached maximum 30-40 min after garlic administration and decreased to basal levels after 100-150 min. A simultaneous decrease in arterial blood pressure was observ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(91)90018-9

    authors： Pantoja CV,Chiang LC,Norris BC,Concha JB

    更新日期：1991-03-01 00:00:00

  • Mucuna pruriens (L.) DC. seed extract inhibits lipopolysaccharide-induced inflammatory responses in BV2 microglial cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Inflammation caused by activated microglia is known to be associated with neurodegenerative diseases, e.g., Parkinson's disease (PD) and Alzheimer's disease (AD). Inhibiting the inflammatory process can be considered a potential strategy for the treatment of inflammation-associated diseas...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113518

    authors： Rachsee A,Chiranthanut N,Kunnaja P,Sireeratawong S,Khonsung P,Chansakaow S,Panthong A

    更新日期：2021-03-01 00:00:00

  • Brine shrimp toxicity and antiplasmodial activity of five Kenyan medicinal plants.

    abstract：:The organic extracts of leaves and roots of five plants used for treating malaria in Central, Nairobi and Rift Valley Provinces, Kenya were tested for brine shrimp lethality and in vitro antiplasmodial activity against chloroquine sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 60% were...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.09.047

    authors： Wanyoike GN,Chhabra SC,Lang'at-Thoruwa CC,Omar SA

    更新日期：2004-01-01 00:00:00

  • (2S)-naringenin from Typha angustata inhibits vascular smooth muscle cell proliferation via a G0/G1 arrest.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Typha angustata is used in traditional Chinese medicine for a variety of clinical disorders. Its pharmacological actions include beneficial effects on hyperlipidemia and myocardial infarction, as well as labor-inducing and antibacterial effects. AIM OF THE STUDY:We investigated the mecha...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.12.038

    authors： Lee JJ,Yi H,Kim IS,Kim Y,Nhiem NX,Kim YH,Myung CS

    更新日期：2012-02-15 00:00:00

  • Phytochemical screening of a Warao pharmacopoeia employed to treat gastrointestinal disorders.

    abstract：:A three-year medical-ethnobotanical investigation among the Warao of the Orinoco Delta in eastern Venezuela documented a pharmacopoeia of 100 plant species representing 45 families. Warao phytotherapists manipulate these plants in diverse manners to produce 259 remedies of various complexities to treat 52 classes of d...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(91)90183-e

    authors： Wilbert W,Haiek G

    更新日期：1991-08-01 00:00:00

  • Herb-drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Scutellariae Radix (SR), the dried root of Scutellariae baicalensis Georgi, has a lot in common with non-steroidal anti-inflammatory drugs (NSAIDs). Their similarities in therapeutic action (anti-inflammation) and metabolic pathways (phase II metabolisms) may lead to co-administration by ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.04.036

    authors： Fong SY,Wong YC,Xie C,Zuo Z

    更新日期：2015-07-21 00:00:00

  • In vivo and in vitro toxicological evaluation of the hydroalcoholic leaf extract of Ageratum conyzoides L. (Asteraceae).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In African traditional medicine, Ageratum conyzoides has been used as purgative, febrifuge, anti-ulcer and wound dressing. To date there is no safety information about long term use of Ageratum conyzoides which contains pyrrolizidine alkaloids, a class of hepatotoxic and carcinogenic phyt...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.07.005

    authors： Diallo A,Eklu-Gadegbeku K,Amegbor K,Agbonon A,Aklikokou K,Creppy E,Gbeassor M

    更新日期：2014-09-11 00:00:00

  • Biological and chemical study of paico (Chenopodium chilense, Chenopodiaceae).

    abstract：:The methanolic extract of the aerial portion of Chenopodium chilense Schrad., used in Chilean traditional medicine as a remedy for stomach-ache, has been found to exert the major spasmolytic activity in acetylcholine contracted rat ileum. This extract, with a complex flavonoid patterns on thin layer chromatography (TL...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(97)00049-4

    authors： García R,Lemus I,Rivera P,Erazo S

    更新日期：1997-07-01 00:00:00

  • Pharmacological basis for the medicinal use of Linum usitatissimum (Flaxseed) in infectious and non-infectious diarrhea.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Linum usitatissimum, commonly known as Flaxseed has traditionally been used for the management of diarrhea and gastrointestinal infections. This study was planned to assess pharmacological basis for the medicinal use of Flaxseed in infectious and non-infectious diarrhea. MATERIALS AND ME...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.11.030

    authors： Palla AH,Khan NA,Bashir S,Ur-Rehman N,Iqbal J,Gilani AH

    更新日期：2015-02-03 00:00:00

  • Tryptanthrin inhibits Th2 development, and IgE-mediated degranulation and IL-4 production by rat basophilic leukemia RBL-2H3 cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Tryptanthrin is a compound isolated from Polygonum tinctorium, which is a known folk medicine with various biological activities. AIM OF THE STUDY:Allergic diseases are initiated by the development of allergen-specific T helper type 2 (Th2) cells and amplified by the degranulation of and...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.12.041

    authors： Iwaki K,Ohashi E,Arai N,Kohno K,Ushio S,Taniguchi M,Fukuda S

    更新日期：2011-03-24 00:00:00

  • Salacia reticulata inhibits differentiation of 3T3-L1 adipocytes.

    abstract：UNLABELLED:ETHOPARMACOLOGICAL RELEVANCE: Salacia reticulata, a herbal medicine which has been used for the treatment of early diabetes in Ayurvedic medicine, is reported to have an anti-obesity effect and to be useful in the treatment of diabetes mellitus, insulin resistance and other metabolic diseases. AIM OF THE ST...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.04.012

    authors： Shimada T,Nagai E,Harasawa Y,Watanabe M,Negishi K,Akase T,Sai Y,Miyamoto K,Aburada M

    更新日期：2011-06-14 00:00:00

  • Cytotoxic and antimicrobial screening of selected terpenoids from Asteraceae species.

    abstract：:Twelve pure compounds originally obtained through a systematic chemotaxonomical study with Mexican plants of the Asteraceae, were subjected to a cytotoxic and in vitro antimicrobial screening. Three different cell lines in culture (KB, KB-VI and P388) were used in the cytotoxicity assay, while antimicrobial activity w...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(94)90019-1

    authors： Villarreal ML,Alvarez L,Alonso D,Navarro V,García P,Delgado G

    更新日期：1994-03-01 00:00:00

  • Belamcanda chinensis (L.) DC-An ethnopharmacological, phytochemical and pharmacological review.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Belamcanda chinensis (L.) DC is the sole species in the genus Belamcanda Adans. (Iridaceae), found mainly in Northeast Asia. Bombus chinensis has long been used in traditional Chinese medicine for its multiple therapeutic uses in the form of antipyretic agents, antidote, expectorant, anti...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2016.03.046

    authors： Zhang L,Wei K,Xu J,Yang D,Zhang C,Wang Z,Li M

    更新日期：2016-06-20 00:00:00

  • Effect and putative mechanism of action of ginseng on the formation of glycated hemoglobin in vitro.

    abstract：:As a non-enzymatic, covalent binding between glucose and protein, glycation is a well-known cause of various forms of diabetic complications. This study was undertaken to determine the effect and mechanism of action of ginseng on the formation of glycated protein. A solution containing hemoglobin and glucose was incub...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.12.008

    authors： Bae JW,Lee MH

    更新日期：2004-03-01 00:00:00

  • Hepatoprotective activity of flavonoids from Cichorium glandulosum seeds in vitro and in vivo carbon tetrachloride-induced hepatotoxicity.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cichorium glandulosum Boiss. et Huet was used historically in Uyghur folk medicine. Its roots, seeds, and aerial parts are extensively used by Uyghur residents in Xinjiang to eliminate savda typhoid, dredge and cure obstructive jaundice variety liver disorders. AIM OF THE STUDY:To evalua...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.08.045

    authors： Tong J,Yao X,Zeng H,Zhou G,Chen Y,Ma B,Wang Y

    更新日期：2015-11-04 00:00:00

  • Histoarchitecture of the genital tract of ovariectomized rats treated with an aqueous extract of Moringa oleifera roots.

    abstract：:The effect of an aqueous extract of Moringa oleifera roots was studied histologically on the genital tract of ovariectomized rats in the presence and absence of estradiol dipropionate and progesterone. Administration of the extract itself stimulated the uterine histoarchitecture as revealed by increases in the height ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(89)90031-7

    authors： Shukla S,Mathur R,Prakash AO

    更新日期：1989-05-01 00:00:00

  • Effects of rhein and Rheum palmatum L. extract on the pharmacokinetics and tissue distribution of aristolochic acid I and its demethylated metabolite in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Aristolochic acid nephropathy (AAN) is a kidney disease caused by the administration of plants containing aristolochic acids (AAs). Aristolochic acid I (AAI) is the main toxic component in AAs. Organic anion transporters (OATs) 1 and 3 mediate the renal uptake of AAI, which is related to ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113537

    authors： Ma L,Shen Z,Hu H,Zhou H,Yu L,Jiang H,Zeng S

    更新日期：2021-03-01 00:00:00