Hepatoprotective activity of flavonoids from Cichorium glandulosum seeds in vitro and in vivo carbon tetrachloride-induced hepatotoxicity.

Abstract:

ETHNOPHARMACOLOGICAL RELEVANCE:Cichorium glandulosum Boiss. et Huet was used historically in Uyghur folk medicine. Its roots, seeds, and aerial parts are extensively used by Uyghur residents in Xinjiang to eliminate savda typhoid, dredge and cure obstructive jaundice variety liver disorders. AIM OF THE STUDY:To evaluate the hepatoprotective activity of total flavonoids (TFs) obtained from C. glandulosum seeds against carbon tetrachloride (CCl4)-induced liver damage in vitro and in vivo. To investigate the mechanisms of hepatoprotective effects for TFs. MATERIALS AND METHODS:The dried seeds of C. glandulosum were extracted with 70% aqueous ethanol, and the extract was chromatographed with D101 macroporous resin. In vitro the antioxidant capacity against lipid peroxidation (LPO) was evaluated using ferrothiocyanate, thiobarbituric acid, β-carotene bleaching, and LPO inhibition assay. The cytotoxicity and hepatoprotective activity of TFs were evaluated in human liver hepatoma cells (HepG2). MTT assay, hepatic injury markers aspartate aminotransferase (AST), alanine aminotransaminase (ALT), lactate dehydrogenase (LDH) leakage, malondialdehyde (MDA), and glutathione (GSH) were performed. In vivo the hepatoprotective activity of TFs against CCl4-induced acute liver injury was evaluated in rats. A series of biochemical and antioxidant parameter levels were measured in liver homogenate. The suppressive effect on pancreatic lipase activity was determined. RESULTS:Results indicated that TFs showed antioxidant capacity against lipid peroxidation (LPO). Administrating CCl4 (1%, v/v) caused a significant decrease in HepG2 viability. Treatment with TFs at doses (62.5, 125, and 250 μg/ml) could significantly ameliorate the cytotoxicity and decline the levels of AST, ALT, and LDH induced by CCl4. The markers including MDA and GSH, which were close to oxidative damage, were restored. Oral treatment with TFs in vivo at doses of 100, 200, and 400 mg/kg significantly reduced the levels of AST, ALT, alkaline phosphatase (ALP), total bilirubin (TB), and thiobarbituric acid reactive substances (TBARs) in the serum compared with CCl4-induced acute liver injury in rats. TFs showed dose-dependent suppressive effects on pancreatic lipase activity, and the IC50 was 1.318 ± 0.164 mg/ml. CONCLUSION:TFs from C. glandulosum seeds demonstrated significant hepatoprotection against CCl4-induced hepatotoxicity. TFs exhibited significant suppression of LPO and pancreatic lipase capacity, which may be the mechanisms of hepatoprotective effects against CCl4. Our results contribute towards validation of the traditional use of C. glandulosum seeds in the treatment of liver disorders.

journal_name

J Ethnopharmacol

authors

Tong J,Yao X,Zeng H,Zhou G,Chen Y,Ma B,Wang Y

doi

10.1016/j.jep.2015.08.045

subject

Has Abstract

pub_date

2015-11-04 00:00:00

pages

355-63

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(15)30110-0

journal_volume

174

pub_type

杂志文章
  • Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: II.

    abstract::A boiling water extract from a mixture of Alstonia boonei and Rauvolfia vomitoria root barks and Elaeis guineensis nuts without pericarp was tested for its antiinflammatory activity by measuring over a period of 17 days the changes in rat ankle diameter caused by subplantar injection of complete Freund's adjuvant. The...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(91)90171-9

    authors: Kweifio-Okai G

    更新日期:1991-05-01 00:00:00

  • Effect and putative mechanism of action of ginseng on the formation of glycated hemoglobin in vitro.

    abstract::As a non-enzymatic, covalent binding between glucose and protein, glycation is a well-known cause of various forms of diabetic complications. This study was undertaken to determine the effect and mechanism of action of ginseng on the formation of glycated protein. A solution containing hemoglobin and glucose was incub...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2003.12.008

    authors: Bae JW,Lee MH

    更新日期:2004-03-01 00:00:00

  • The Chinese herbal formulae (Yitangkang) exerts an antidiabetic effect through the regulation of substance metabolism and energy metabolism in type 2 diabetic rats.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Type 2 diabetes mellitus (T2DM) regarded as a "hot" disease in traditional Chinese medicine (TCM). Accordingly, TCM uses a cold drug or formula such as the Chinese herbal formulae "Yitangkang" (YTK) as a treatment. YTK exhibited a good clinical antidiabetic effect in several experiments. ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.111942

    authors: Han X,Yang Y,Metwaly AM,Xue Y,Shi Y,Dou D

    更新日期:2019-07-15 00:00:00

  • Metabolomics coupled with SystemsDock reveal the protective effect and the potential active components of Naozhenning granule against traumatic brain injury.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Naozhenning granule (NZN), a widely traditional Chinese medicine (TCM) prescription with a long history of clinical, which is mainly used in the treatment of concussion, cerebral post-traumatic syndrome, consists of Di Huang (Radix of Rehmannia glutinosa (Gaertn.) DC.), Dang Gui (Radix of...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.112247

    authors: Cao J,Duan Y,Liu Y,Liu H,Wei C,Wang J,Qin X,Wang X,Li Z

    更新日期:2020-01-10 00:00:00

  • Investigating wound healing, tyrosinase inhibitory and antioxidant activities of the ethanol extracts of Salvia cryptantha and Salvia cyanescens using in vivo and in vitro experimental models.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Salvia L. species are widely used against wounds and skin infections in Turkish folk medicine. AIM OF THE STUDY:The aim of the present study is to evaluate wound healing activity of the ethanol (EtOH) extracts of Salvia cryptantha and Salvia cyanescens. MATERIALS AND METHODS:For the ass...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.02.022

    authors: Süntar I,Akkol EK,Senol FS,Keles H,Orhan IE

    更新日期:2011-04-26 00:00:00

  • Prevention of UV radiation-induced cutaneous photoaging in mice by topical administration of patchouli oil.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Pogostemon cablin has been widely used in traditional Chinese medicine for the treatment of many diseases, including skin disorders. In the skin beauty and care prescriptions, Pogostemon cablin is one of the top ten frequently used traditional Chinese medicines. AIM OF THE STUDY:The pres...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2014.04.020

    authors: Lin RF,Feng XX,Li CW,Zhang XJ,Yu XT,Zhou JY,Zhang X,Xie YL,Su ZR,Zhan JY

    更新日期:2014-06-11 00:00:00

  • Anti-inflammatory activity of dried flower extracts of Aegle marmelos in Wistar rats.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Almost all part of the plant Aegle marmelos (Bael tree) has been used in the traditional medicine systems of Asian countries to treat various diseases over many centuries. The water extract of the dried flowers of Aegle marmelos is a commonly used beverage among Sri Lankan population in r...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2013.12.043

    authors: Kumari KDKP,Weerakoon TCS,Handunnetti SM,Samarasinghe K,Suresh TS

    更新日期:2014-02-12 00:00:00

  • Anti-inflammatory and wound healing effects of cream containing Curcuma mangga extract.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Curcuma mangga Valeton & Van Zijp. (Zingiberaceae family) contains curcuminoids and diterpenes which have anti-inflammatory effect. In traditional use, the elixir of this plant has been used to detoxify the poisonous plants, treatment of gastric ulcer, chest pain, fever, skin disease and ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.111828

    authors: Srirod S,Tewtrakul S

    更新日期:2019-06-28 00:00:00

  • The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens.

    abstract::Extracts from Helichrysum aureonitens are used topically by the indigenous people of South Africa against infections. The antimicrobial activity-guided fractionation by bioautography of the acetone extract from the aerial parts of H. aureonitens led to the isolation of 3,5,7-trihydroxyflavone (galangin). Evaluation of...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(97)00065-2

    authors: Afolayan AJ,Meyer JJ

    更新日期:1997-08-01 00:00:00

  • Inhibition of lipopolysaccharide and interferon-gamma-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by Lithospermi radix in mouse peritoneal macrophages.

    abstract::Lithospermi radix (LR, root of Lithospermum erythrorhizon Siebold. et Zuccarinii) has been used to treat various conditions, such as septic shock, eczema and burns. In this study, the effect of LR on lipopolysaccharide (LPS) and recombinant interferon-gamma (rIFN-gamma)-induced production of nitric oxide (NO) and tumo...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2005.06.028

    authors: Chung HS,Kang M,Cho C,Park S,Kim H,Yoon YS,Kang J,Shin MK,Hong MC,Bae H

    更新日期:2005-12-01 00:00:00

  • Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm.

    abstract::Ethanol extract of the leaves of Embelia ribes Burm. (Myrsinaceae) and its isolated quinone compound embelin were screened for wound healing activity by excision, incision and dead space wound models on Swiss Albino Rats. Significant wound healing activity was observed in both ethanol crude extract (30 mg/ml) and the ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2006.09.003

    authors: Kumara Swamy HM,Krishna V,Shankarmurthy K,Abdul Rahiman B,Mankani KL,Mahadevan KM,Harish BG,Raja Naika H

    更新日期:2007-02-12 00:00:00

  • Ethnobotanical inventory of medicinal plants used by the Guaymi Indians in western Panama. Part II.

    abstract::A list of newly identified plants is presented to supplement Part I (Joly et al. (1987) Journal of Ethnopharmacology 20, 145-171). A comparative analysis is made between our work and two other recent inventories of plants used by the Guaymi Indians of Panama and Costa Rica. As in Part I, the results of a literature su...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(90)90029-s

    authors: Joly LG,Guerra S,Séptimo R,Solís PN,Correa MD,Gupta MP,Levy S,Sandberg F,Perera P

    更新日期:1990-02-01 00:00:00

  • The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model.

    abstract::Paeoniflorin and sinomenine, derived from the root of Paeonia lactiflora Pall. (family Ranunculaceae) and the stem of Sinomenium acutum Rehder & Wilson (family Menispermaceae), respectively, have been, and are currently, widely used for treatment of rheumatic and arthritic diseases in China and Japan. Our previous stu...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2005.08.020

    authors: Chan K,Liu ZQ,Jiang ZH,Zhou H,Wong YF,Xu HX,Liu L

    更新日期:2006-02-20 00:00:00

  • UPLC-MS-based metabonomic analysis of intervention effects of Da-Huang-Xiao-Shi decoction on ANIT-induced cholestasis.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Cholestasis, caused by hepatic accumulation of bile acids, is a serious manifestation of liver diseases resulting in liver injury, fibrosis, and liver failure with limited therapies. Da-Huang-Xiao-Shi decoction (DHXSD) is a representative formula for treating jaundice and displays bright ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.111860

    authors: Zhu G,Feng F

    更新日期:2019-06-28 00:00:00

  • Network pharmacology combined with metabolomics to study the mechanism of Shenyan Kangfu Tablets in the treatment of diabetic nephropathy.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Shenyan Kangfu Tablets (SYKFT) is a traditional prescription evolved from Shenqi Pills. It has been included in the Synopsis of the Golden Chamber for more than 2000 years. SYKFT was listed as a national Chinese medicine protected class by the China Food and Drug Administration. Diabetic ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2021.113817

    authors: Wang X,He Q,Chen Q,Xue B,Wang J,Wang T,Liu H,Chen X

    更新日期:2021-01-11 00:00:00

  • Potential of medicinal plants from the Brazilian semi-arid region (Caatinga) against Staphylococcus epidermidis planktonic and biofilm lifestyles.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants from the Caatinga, a Brazilian xeric shrubland, are used in folk medicine to treat infections. These ethnopharmacological data can contribute to obtaining new antimicrobial/antibiofilm extracts and natural product prototypes for the development of new drugs. The aim of th...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.05.030

    authors: Trentin Dda S,Giordani RB,Zimmer KR,da Silva AG,da Silva MV,Correia MT,Baumvol IJ,Macedo AJ

    更新日期:2011-09-01 00:00:00

  • Antitrichomonal action of emodin in mice.

    abstract::Emodin, an active component contained in the root and rhizome of Rheum palmatum L. (Polygonaceae), was found to have an inhibitory effect on the pathogenicity of Trichomonas vaginalis in mice. Emodin delayed the development of subcutaneous abscesses due to infection of this parasite. Also, it cures the intravaginal in...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(93)90055-a

    authors: Wang HH

    更新日期:1993-10-01 00:00:00

  • Utilization of the extract of Cedrus deodara (Roxb. ex D.Don) G. Don against the biofilm formation and the expression of virulence genes of cariogenic bacterium Streptococcus mutans.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Cedrus deodara (Roxb. ex D.Don) G. Don is applied as anti-inflammatory and anti-infection agents in folklore medicine. AIM OF THE STUDY:The present study aimed to assess the antimicrobial activity of Cedrus deodara (Roxb. ex D.Don) G. Don extract (CDE) against Streptococcus mutans biofil...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2020.112856

    authors: Zhang Z,Lyu X,Xu Q,Li C,Lu M,Gong T,Tang B,Wang L,Zeng W,Li Y

    更新日期:2020-07-15 00:00:00

  • The adjuvant effects of Antrodia Camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells.

    abstract:AIM OF THE STUDY:The objectives of this study were to investigate the adjuvant anti-tumor effects of Antrodia camphorate in human hepatoma cells (C3A and PLC/PRF/5) which are resistance to most anti-tumor agents, elucidate the possible regulation pathways, and measure the tumor growth and survival rate in xenograft-nud...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2008.05.001

    authors: Chang CY,Huang ZN,Yu HH,Chang LH,Li SL,Chen YP,Lee KY,Chuu JJ

    更新日期:2008-08-13 00:00:00

  • The nitric oxide-producing properties of Solanum lyratum.

    abstract::We examined the effect of Solanum lyratum Thunb. (Solanaceae) (SL) on the production of nitric oxide (NO). Stimulation of mouse peritoneal macrophages with SL after the treatment of recombinant interferon-gamma (rIFN-gamma) resulted in increased NO synthesis. SL had no effect on NO synthesis by itself. When SL was use...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(99)00011-2

    authors: Kim HM,Kim MJ,Li E,Lyu YS,Hwang CY,An NH

    更新日期:1999-11-01 00:00:00

  • Screening of seven selected Rwandan medicinal plants for antimicrobial and antiviral activities.

    abstract::Aqueous EtOH (80%) extracts of seven plants used by Rwandan traditional healers to treat infections, were screened for antibacterial, antifungal, and antiviral activities. Only two of the selected plants showed a true antiviral activity against herpes simplex virus type 1, while all of them exhibited virucidal propert...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(98)00154-8

    authors: Sindambiwe JB,Calomme M,Cos P,Totté J,Pieters L,Vlietinck A,Vanden Berghe D

    更新日期:1999-04-01 00:00:00

  • Acute intraperitoneal and oral toxicity of the leaf glycosidic extract of Trigonella foenum-graecum in mice.

    abstract::The present study was carried out to determine the acute toxicity of the leaf glycosidic extract of Trigonealla foenum-graecum by estimation of its medium lethal dose (LD(50)) after oral and intraperitoneal administration to mice and also to identify the target organs for its possible toxic effects. The main target or...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(99)00109-9

    authors: Abdel-Barry JA,Al-Hakiem MH

    更新日期:2000-04-01 00:00:00

  • Botany, traditional uses, phytochemistry and pharmacology of Waltheria indica L. (syn. Waltheria americana): a review.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Waltheria indica L. (syn. Waltheria americana) is commonly used in traditional medicine in Africa, South America and Hawaii, mainly against pain, inflammation, conditions of inflammation, diarrhea, dysentery, conjunctivitis, wounds, abscess, epilepsy, convulsions, anemia, erectile dysfunc...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jep.2013.03.080

    authors: Zongo F,Ribuot C,Boumendjel A,Guissou I

    更新日期:2013-06-21 00:00:00

  • Metabolomic strategy to study therapeutic and synergistic effects of tanshinone IIA, salvianolic acid B and ginsenoside Rb1 in myocardial ischemia rats.

    abstract:AIM OF THE STUDY:Tanshinone IIA (T), salvianolic acid B (S) and ginsenoside Rb1 (G) are the three major active ingredients of Compound Danshen Formula (CDF) for its protective effects on myocardial ischemia (MI). In this study, we aimed to investigate therapeutic and synergistic effects of TSG (combination of T, S and ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2010.11.048

    authors: Lu Y,Liu X,Liang X,Xiang L,Zhang W

    更新日期:2011-03-08 00:00:00

  • Effects of a Chinese herbal medicine, keishi-bukuryo-gan, on the gonadal system of rats.

    abstract::Keishi-bukuryo-gan (TJ-25) is a traditional Chinese herbal remedy containing five components: bark of Cinnamomum cassia, root of Paeonia lactiflora, seed of Prunus persica or P. persiba var. davidiana, carpophores of Poria cocos and root bark of Paeonia suffruticosa. This preparation has been used in the treatment of ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(88)90002-5

    authors: Sakamoto S,Kudo H,Kawasaki T,Kuwa K,Kasahara N,Sassa S,Okamoto R

    更新日期:1988-07-01 00:00:00

  • A comprehensive quality evaluation of Fuzi and its processed product through integration of UPLC-QTOF/MS combined MS/MS-based mass spectral molecular networking with multivariate statistical analysis and HPLC-MS/MS.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Aconiti Lateralis Radix Praeparata (the Chinese name is Fuzi, FZ), the lateral or daughter root of Aconitum carmichaelii Debx. (Ranunculaceae), is a controversial traditional Chinese medicine (TCM) that is universally distributed and applied in many countries, such as China, Japan, Korea,...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2020.113455

    authors: Lei H,Zhang Y,Ye J,Cheng T,Liang Y,Zu X,Zhang W

    更新日期:2021-02-10 00:00:00

  • Effects of hydroethanolic extracts of Balanites aegyptiaca (L.) Delile (Balanitaceae) on some resistant pathogens bacteria isolated from wounds.

    abstract:BACKGROUND:The bark of Balanites aegyptiaca (L.) Delile (Balanitaceae) is widely used in the Togolese folk medicine for the treatment of wounds, malaria and skin diseases. This study aimed to evaluate the antioxidant properties and the activity of the bark extract of this plant against some resistant bacteria isolated ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2015.01.051

    authors: Anani K,Adjrah Y,Ameyapoh Y,Karou SD,Agbonon A,de Souza C,Gbeassor M

    更新日期:2015-04-22 00:00:00

  • Dual mechanisms of a Sri Lankan traditional polyherbal mixture in the improvement of pancreatic beta cell functions and restoration of lipoprotein alterations in streptozotocin induced diabetic rats.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Traditional polyherbal preparations have been utilized in Sri Lanka since ancient times and have gained a wide acceptance throughout the country. Although an extensive body of evidence supports the use of traditional herbal mixtures in the treatment of diabetes mellitus, only a few polyhe...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2020.113613

    authors: Liyanagamage DSNK,Jayasinghe S,Attanayake AP,Karunaratne V

    更新日期:2021-03-01 00:00:00

  • Evaluation of the toxicity potential of acute and sub-acute exposure to the aqueous root extract of Aristolochia ringens Vahl. (Aristolochiaceae).

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Aristolochia ringens Vahl. (Aristolochiaceae) is used traditionally in Nigeria for managing a number of ailments including gastrointestinal disturbances, rheumatoid arthritis, pile, insomnia, oedema, and snake bite venom. Some studies in our laboratory have demonstrated a scientific justi...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.112150

    authors: Aigbe FR,Sofidiya OM,James AB,Sowemimo AA,Akindere OK,Aliu MO,Dosunmu AA,Chijioke MC,Adeyemi OO

    更新日期:2019-11-15 00:00:00

  • Effect of piperine on inhibition of FFA induced TLR4 mediated inflammation and amelioration of acetic acid induced ulcerative colitis in mice.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Piperine, a main component of Piper longum Linn. and Piper nigrum Linn., is a plant alkaloid with a long history of medicinal use. Piperine exhibits antidepressant, hepatoprotective, anti-metastatic, anti-thyroid, immunomodulatory, antitumor and anti-inflammatory activities, However its t...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2015.01.039

    authors: Gupta RA,Motiwala MN,Dumore NG,Danao KR,Ganjare AB

    更新日期:2015-04-22 00:00:00