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Preliminary evaluation: the effects of Aloe ferox Miller and Aloe arborescens Miller on wound healing.

Abstract：

AIM OF THE STUDY:Genus Aloe has been traditionally utilized for medicinal purpose for decades. Compared with Aloe vera gel, the qualitative assessment for the therapeutic effects of the other two Aloe species, Aloe ferox Miller and Aloe arborescens Miller, for their topical wound healing was less addressed. Therefore, the aim of present study is to provide the positive evidence for Aloe ferox Miller and Aloe arborescens Miller supporting their therapeutic properties for topical treatment of skin wounds. MATERIALS AND METHODS:Two types of the whole-leaf juice prepared from either Aloe ferox Miller or Aloe arborescens Miller were used in this study. Incision wound healing was investigated using both the rat and rabbit model. The wound closure rate with and without the topical administration of the whole-leaf juice were monitored. The changes in wound characteristics were traced and wound severity was scored on different days. The anti-microorganism actions of each whole-leaf juice preparation were evaluated by measuring their inhibition growth effects on four bacterial strains and three fungal spores. The toxic influence owing to topical application of Aloe whole-leaf juice on intact and damaged skin was also assessed. RESULTS AND CONCLUSIONS:Our results indicated that the two types of whole-leaf juice preparations exhibit the therapeutic properties, including facilitation of the healing process, selective inhibition of the microbial growth and zero side-effect on the skin, during the observation period. It is concluded that both of Aloe whole-leaf juice preparations have the positive potential for skin medicinal application.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Jia Y,Zhao G,Jia J

doi

10.1016/j.jep.2008.08.008

subject

Has Abstract

pub_date

2008-11-20 00:00:00

pages

181-9

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(08)00431-5

journal_volume

120

pub_type

杂志文章

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