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Chemopreventive activity of Ocimum sanctum seed oil.

Abstract：

:The seed oil of Ocimum sanctum was evaluated for chemopreventive activity against subcutaneously injected 20-methylcholanthrene induced-fibrosarcoma tumors in the thigh region of Swiss albino mice. Supplementation of maximal tolerated dose (100 microl/kg body weight) of the oil significantly reduced 20-methylcholanthrene induced tumor incidence and tumor volume. The enhanced survival rate and delay in tumor incidence was observed in seed oil supplemented mice. Liver enzymatic (superoxide dismutase, catalase, glutathione-S-transferase), non-enzymatic antioxidants (reduced glutathione) and lipid peroxidation end product, malondialdehyde levels were significantly modulated with oil treatment as compared to untreated 20-methylcholanthrene injected mice. The results of this study suggest that the potential chemopreventive activity of the oil is partly attributable to its antioxidant properties. The chemopreventive efficacy of 100 microl/kg seed oil was comparable to that of 80 mg/kg of vitamin E.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Prakash J,Gupta SK

doi

10.1016/s0378-8741(00)00194-x

keywords:

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

29-34

issue

1-2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(00)00194-X

journal_volume

72

pub_type

杂志文章

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