Cupressus lusitanica (Cupressaceae) leaf extract induces apoptosis in cancer cells.

Abstract:

:A crude ethanolic extract of Cupressus lusitanica Mill. leaves demonstrate cytotoxicity in a panel of cancer cell lines. Cell death was due to apoptosis, as assessed by morphologic features (chromatin condensation and apoptotic bodies formation) and specific DNA fragmentation detected by in situ end-labeling of DNA breaks (TUNEL). The apoptotic cell death was induced timely in a dose-dependent manner. Despite the absence of changes in the expression levels of antiapoptotic protein Bcl-2, proapoptotic Bax protein variants omega and delta were increased. These results warrant further research of possible antitumor compounds in this plant.

journal_name

J Ethnopharmacol

authors

Lopéz L,Villavicencio MA,Albores A,Martínez M,de la Garza J,Meléndez-Zajgla J,Maldonado V

doi

10.1016/s0378-8741(01)00417-2

keywords:

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

115-20

issue

2-3

eissn

0378-8741

issn

1872-7573

pii

S0378874101004172

journal_volume

80

pub_type

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