当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Effect of salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cells.

Effect of salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cells.

Abstract：

AIM OF THE STUDY:Salvianolic-acid B (SA-B) is an effective component of Radix Salviae miltiorrhizae for anti-hepatic fibrotic herbs. MAPK signaling pathway has been implicated in hepatic stellate cells (HSC) stimulated by TGF-(1. We have investigated the effect of SA-B on MAPK pathway in rat HSC. MATERIALS AND METHODS:To observe the pharmacological effect of SA-B on HSC, SA-B was added into the medium of primary HSC. TGF-(1 was added during last 2h, and PD98059 (ERK inhibitor) and SB203580 (p38 inhibitor) were added just 30 min before adding TGF-(1. MEF2 and Col. I were measured by luciferase reporter gene assay and Western blot. (-SMA, MEF2, Raf, ERK, p-ERK, MEK, p-MEK, p38, p-p38, MKK3 and p-MKK3/6 were assayed by Western blot. Activity of MMP-2 and MMP-9 was analyzed by zymography. Each experiment was repeated for three times. RESULTS:The expression of (-SMA and Col. I in HSC was inhibited by SA-B. There was no effect of SA-B on the activity of MMP-2 or MMP-9 in the media of cultured HSC. Phosphorylation of ERK1/2 in HSC stimulated with or without TGF-(1 was inhibited by SA-B. Specifically, phosphorylation of MEK (upstream kinase of ERK pathway) was inhibited by SA-B. SA-B also inhibited phosphorylation of MKK3/6 (upstream kinases of p38 pathway) and inhibited the synthesis of MEF2. CONCLUSIONS:SA-B performs anti-hepatic fibrosis through inhibiting ERK and p38 MAPK pathway in HSC. SA-B inhibits ERK pathway via inhibiting phosphorylation of MEK and inhibits p38 MAPK pathway via blocking phosphorylation of MKK3/6 and inhibiting expression of MEF2 in HSC with or without TGF-(1 stimulation.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Lv Z,Song Y,Xue D,Zhang W,Cheng Y,Xu L

doi

10.1016/j.jep.2010.05.026

subject

Has Abstract

pub_date

2010-11-11 00:00:00

pages

384-92

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(10)00346-6

journal_volume

132

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats.

    abstract：:Antinociceptive, anti-inflammatory and acute toxicity of the aqueous infusion and ethanolic maceration extracts of the aerial parts of Zataria multiflora Boiss were studied in mice and rats. Antinociceptive activity was done using hot-plate and writhing tests. The effect of the extracts against acute inflammation was ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(00)00238-5

    authors： Hosseinzadeh H,Ramezani M,Salmani G

    更新日期：2000-12-01 00:00:00

  • Himatanthus drasticus (Apocynaceae) latex reduces oxidative stress and modulates CD4+, CD8+, FoxP3+ and HSP-60+ expressions in Sarcoma 180-bearing mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In Brazil, latex of Himatanthus drasticus is used to treat inflammation, wound healing and cancer. The present study evaluated the antitumoral potential of H. drasticus latex (HdCL) in Sarcoma 180-bearing mice (S180). MATERIALS AND METHODS:HdCL was obtained in Crato-CE, Brazil. Qualitati...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.09.043

    authors： Santos GJL,Oliveira ES,Pinheiro ADN,da Costa PM,de Freitas JCC,de Araújo Santos FG,Maia FMM,de Morais SM,Nunes-Pinheiro DCS

    更新日期：2018-06-28 00:00:00

  • Free radical scavenging activity of the alcoholic extract of Trewia polycarpa roots in arthritic rats.

    abstract：:The alcoholic extract of Trewia polycarpa roots (TPE), which exhibited significant anti-inflammatory activity, was evaluated for the possible mode of action by studying its antioxidant potential in adjuvant-induced arthritic rats. The biological defence system constituting the superoxide dismutase, glutathione peroxid...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00143-0

    authors： Chamundeeswari D,Vasantha J,Gopalakrishnan S,Sukumar E

    更新日期：2003-09-01 00:00:00

  • Oral Uncaria rhynchophylla (UR) reduces kainic acid-induced epileptic seizures and neuronal death accompanied by attenuating glial cell proliferation and S100B proteins in rats.

    abstract：AIM OF THE STUDY:Epilepsy is a common clinical syndrome with recurrent neuronal discharges in cerebral cortex and hippocampus. Here we aim to determine the protective role of Uncaria rhynchophylla (UR), an herbal drug belong to Traditional Chinese Medicine (TCM), on epileptic rats. MATERIALS AND METHODS:To address thi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.03.018

    authors： Lin YW,Hsieh CL

    更新日期：2011-05-17 00:00:00

  • Skeletal muscle relaxant action of an aqueous extract of Portulaca oleracea in the rat.

    abstract：:The aqueous extract of Portulaca oleracea produced skeletal muscle relaxation in rats following i.p. or oral administration, as assessed by the prolongation of pull-up time. The i.p. route of administration was more effective. When compared with chlordiazepoxide (20 mg/kg, i.p.), diazepam (40 mg/kg, i.p.) and dantrole...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(87)90002-x

    authors： Parry O,Okwuasaba FK,Ejike C

    更新日期：1987-05-01 00:00:00

  • Effects of rhein and Rheum palmatum L. extract on the pharmacokinetics and tissue distribution of aristolochic acid I and its demethylated metabolite in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Aristolochic acid nephropathy (AAN) is a kidney disease caused by the administration of plants containing aristolochic acids (AAs). Aristolochic acid I (AAI) is the main toxic component in AAs. Organic anion transporters (OATs) 1 and 3 mediate the renal uptake of AAI, which is related to ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113537

    authors： Ma L,Shen Z,Hu H,Zhou H,Yu L,Jiang H,Zeng S

    更新日期：2021-03-01 00:00:00

  • Anticancer effects of ethanolic neem leaf extract on prostate cancer cell line (PC-3).

    abstract：:Prostate cancer (PC) is the most prevalent cancer and the leading cause of male cancer death. Azadirachta indica (neem tree) has been used successfully centuries to reduce tumors by herbalists throughout Southeast Asia. Here the present study indicated that an ethanolic extract of neem has been shown to cause cell dea...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.11.006

    authors： Kumar S,Suresh PK,Vijayababu MR,Arunkumar A,Arunakaran J

    更新日期：2006-04-21 00:00:00

  • Nigerian folk medicine: practices and beliefs of the Ondo people.

    abstract：:One hundred informants including full time/part time herbalists, old ladies, family heads and village heads were interviewed for the type of plants used in their homes for the treatment of some common diseases. Forty eight plant species were found to be used by Ondo people in folk medicine. Fourteen species were found...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(86)90004-8

    authors： Gill LS,Akinwumi C

    更新日期：1986-12-01 00:00:00

  • Biological effect of Opuntia ficus indica (L.) Mill. (Cactaceae) waste matter. Note I: diuretic activity.

    abstract：:In this work we studied in rat the diuretic activity of Opuntia ficus indica (L.) Mill. (Cactaceae) waste matter. The cladodes, flowers and non commerciable fruits were collected in S. Cono (CT, Sicily) cultivation. Acute and chronic diuretic activity of 15% infusion of cladodes, flowers and fruits were assayed. Natri...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00337-3

    authors： Galati EM,Tripodo MM,Trovato A,Miceli N,Monforte MT

    更新日期：2002-01-01 00:00:00

  • Pharmacological effects of Agapanthus africanus on the isolated rat uterus.

    abstract：:The Agapanthus africanus plant is used by South African traditional healers as a phytomedicine in herbal remedies to treat pregnancy-related ailments and to augment labour. It has already been shown that an aqueous extract of A. africanus causes smooth muscle contractions in the isolated uterus and ileum preparations....

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(98)00224-4

    authors： Veale DJ,Havlik I,Oliver DW,Dekker TG

    更新日期：1999-09-01 00:00:00

  • Effects of hydroxysafflor yellow A on the activity and mRNA expression of four CYP isozymes in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In traditional therapy with Chinese medicine, hydroxysafflor yellow A (HSYA), a main active component isolated from the dried flower of Carthamus tinctorius L., is the principal efficiency ingredient of Safflor Yellow Injection. Now HSYA has been demonstrated to have good pharmacological ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.12.025

    authors： Xu RA,Xu ZS,Ge RS

    更新日期：2014-02-12 00:00:00

  • Antitrichomonal action of emodin in mice.

    abstract：:Emodin, an active component contained in the root and rhizome of Rheum palmatum L. (Polygonaceae), was found to have an inhibitory effect on the pathogenicity of Trichomonas vaginalis in mice. Emodin delayed the development of subcutaneous abscesses due to infection of this parasite. Also, it cures the intravaginal in...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(93)90055-a

    authors： Wang HH

    更新日期：1993-10-01 00:00:00

  • Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Hericium is a genus of mushrooms (fungus) in the Hericiaceae family. Hericium erinaceus (HE) has been used for the treatment of digestive diseases for over 2000 years in China. HE possesses many beneficial functions such as anticancer, antiulcer, antiinflammation and antimicrobial effects...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.03.003

    authors： Li G,Yu K,Li F,Xu K,Li J,He S,Cao S,Tan G

    更新日期：2014-04-28 00:00:00

  • Effects of Red Ginseng extract on allergic reactions to food in Balb/c mice.

    abstract：AIM OF THE STUDY:Red Ginseng roots (Panax ginseng C.A. Meyer) have traditionally been thought to have anti-allergic effects, but their influence on food-induced allergic responses is unclear. MATERIALS AND METHODS:This study examined the effects of a Red Ginseng extract on an ova-albumin (OVA)-evoked allergic reaction...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.08.012

    authors： Sumiyoshi M,Sakanaka M,Kimura Y

    更新日期：2010-10-28 00:00:00

  • Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway.

    abstract：AIM OF THE STUDY:To investigate the effect of tashinone IIA (TA) on intimal hyperplasia in a rat model of carotid artery balloon injury and on the proliferation of cultured vascular smooth muscle cells (VSMCs) induced by fetal bovine serum (FBS) and its underlying mechanisms. MATERIALS AND METHODS:Carotid artery injur...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.03.021

    authors： Li X,Du JR,Yu Y,Bai B,Zheng XY

    更新日期：2010-05-27 00:00:00

  • The traditional drug Gongjin-Dan ameliorates chronic fatigue in a forced-stress mouse exercise model.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Gongjin-Dan is a representative traditional Oriental medicine herbal drug that has been used to treat chronic fatigue symptoms for several hundred years. We evaluated the anti-fatigue effects of Gongjin-Dan and the underlying mechanisms in a chronic forced exercise mouse model. METHODS A...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.04.001

    authors： Hong SS,Lee JY,Lee JS,Lee HW,Kim HG,Lee SK,Park BK,Son CG

    更新日期：2015-06-20 00:00:00

  • Anti-apoptotic effect of modified Chunsimyeolda-tang, a traditional Korean herbal formula, on MPTP-induced neuronal cell death in a Parkinson's disease mouse model.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The modified-Chungsimyeolda-tang (DG) is an important traditional Korean herbal formula used in traditional oriental medicine for treatment of cerebrovascular disorders, including stroke. The formula is based on the book "Dongui Sasang Shinpyun". AIM OF THE STUDY:In the previous studies,...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.11.013

    authors： Li H,Park G,Bae N,Kim J,Oh MS,Yang HO

    更新日期：2015-12-24 00:00:00

  • A network pharmacology approach to discover action mechanisms of Yangxinshi Tablet for improving energy metabolism in chronic ischemic heart failure.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Most cardiovascular diseases ultimately result in heart failure, an intractable problem in modern medicine. Yangxinshi tablet (YXS) is a Chinese medicine formula that is used clinically to treat coronary heart disease. However, the active compounds, potential targets, and pharmacological ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112227

    authors： Wu RM,Jiang B,Li H,Dang WZ,Bao WL,Li HD,Ye G,Shen X

    更新日期：2020-01-10 00:00:00

  • Antidiabetic potentials of ethanolic extract of Aristolochia ringens (Vahl.) roots.

    abstract：ETHNOPHARMACOLOGICAL IMPORTANCE:Oral administration of alcoholic decoctions of Aristolochia ringens is used extensively by Traditional Medicine Practitioners (TMP) of Yoruba heritage in South west, Nigeria for the management of diabetes and its associated complications. AIM OF THE STUDY:To assess the potentials of roo...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.02.002

    authors： Sulyman AO,Akolade JO,Sabiu SA,Aladodo RA,Muritala HF

    更新日期：2016-04-22 00:00:00

  • Petroleum ether extractive of the hips of Rosa multiflora ameliorates collagen-induced arthritis in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The hip of Rosa multiflora Thunb. (HRM) has been traditionally used as a dietary supplement and a herbal remedy for the treatment of various diseases, including inflammation, osteoarthritis, rheumatoid arthritis and chronic pain, in China. The current study was to evaluate the therapeutic...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.09.026

    authors： Wu J,Liu X,Chan CO,Mok DK,Chan SW,Yu Z,Chen S

    更新日期：2014-11-18 00:00:00

  • Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice.

    abstract：:Melissa officinalis L. (Labiatae), Morus alba L. (Moraceae), and Artemisia capillaris Thunb. (Compositae) are suggested to be involved in the regulation of hyperlipidemia. We hypothesized that Ob-X, a mixture of three herbs, Morus alba, Melissa officinalis and Artemisia capillaris [corrected] improves lipid metabolism...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.09.029

    authors： Lee J,Chae K,Ha J,Park BY,Lee HS,Jeong S,Kim MY,Yoon M

    更新日期：2008-01-17 00:00:00

  • Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita.

    abstract：AIM OF THE STUDY:Artemisia vestita is a common traditional Tibetan medicinal plant which has been used widely in China for treating various inflammatory diseases. Since little is known about its active components, the purpose of this study was to isolate and identify the immunosuppressive compounds from Artemisia vesti...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.07.029

    authors： Yin Y,Gong FY,Wu XX,Sun Y,Li YH,Chen T,Xu Q

    更新日期：2008-10-30 00:00:00

  • A traditional herbal formula, Hyangsa-Pyeongwi san (HPS), improves quality of life (QoL) of the patient with functional dyspepsia (FD): randomized double-blinded controlled trial.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Hyangaa-Pyeongwi san is the most well known description in Traditional Chinese Medicine for treating functional gastrointestinal disorders. Functional dyspepsia (FD) is a main concern of intimidating quality of life (QoL) in recent days. Although many medicines have been developed to impr...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jep.2013.10.033

    authors： Kim JB,Shin JW,Kang JY,Son CG,Kang W,Lee HW,Lee DS,Park YC,Cho JH

    更新日期：2014-01-01 00:00:00

  • Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences.

    abstract：ETHNOPHARMOCOLOGICAL RELEVANCE:Terminalia catappa Linn (Combretaceae) is a medicinal plant with anti-inflammatory, anti-diarrhoeal and antioxidant properties, frequently found in tropical regions. Considering its characteristics, it could be useful for the treatment of inflammatory bowel disease, which is associated wi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.07.056

    authors： Abiodun OO,Rodríguez-Nogales A,Algieri F,Gomez-Caravaca AM,Segura-Carretero A,Utrilla MP,Rodriguez-Cabezas ME,Galvez J

    更新日期：2016-11-04 00:00:00

  • Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Arctium lappa and Tussilago farfara (Asteraceae) are two plant species used traditionally as antitubercular remedies. The aim of this study was (i) to screen Arctium lappa and Tussilago farfara extracts for activity against Mycobacterium tuberculosis and (ii) to isolate and identify the c...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.06.034

    authors： Zhao J,Evangelopoulos D,Bhakta S,Gray AI,Seidel V

    更新日期：2014-08-08 00:00:00

  • Polysaccharides of vinegar-baked radix bupleuri promote the hepatic targeting effect of oxymatrine by regulating the protein expression of HNF4α, Mrp2, and OCT1.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Vinegar-baked Radix Bupleuri (VBRB) is a processed form of Bupleurum chinense DC. As a well-known meridian-guiding drug, it is traditionally used as a component of traditional Chinese medicine formulations indicated for the treatment of liver diseases. However, the liver targeting compone...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113471

    authors： Wu Y,Liu L,Zhao Y,Zhao R

    更新日期：2021-03-01 00:00:00

  • Immunostimulant effects of Capparis zeylanica Linn. leaves.

    abstract：:The present study was undertaken to explore the immunomodulatory activity of ethanolic and water extracts of Capparis zeylanica Linn. (family: Capparidaceae) leaves on neutrophil adhesion test, humoral response to sheep red blood cells, delayed-type hypersensitivity, phagocytic activity and cyclophosphamide-induced my...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.03.041

    authors： Ghule BV,Murugananthan G,Nakhat PD,Yeole PG

    更新日期：2006-11-24 00:00:00

  • Medicinal plants used for cardiovascular diseases in Navarra and their validation from official sources.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:This paper provides significant ethnopharmacological information on plants used to treat cardiovascular diseases in Navarra, Spain. MATERIAL AND METHODS:Information was collected using semi-structured ethnobotanical interviews with 667 informants (mean age 72; 55.47% women, 44.53% men) i...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.09.047

    authors： Calvo MI,Cavero RY

    更新日期：2014-11-18 00:00:00

  • Cytotoxic ethnic Yao medicine Baizuan, leaves of Schisandra viridis A. C. Smith.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The ethnic Chinese Yao medicine Baizuan, which are the leaves of Schisandra viridis A. C. Smith, is traditionally used, in combination with other herbs, to soften hard lumps and dispel nodes in the treatment of cancer, however, this property has not been well studied with a clear indicati...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.09.016

    authors： Hou X,Deng J,Zhang Q,Wang D,Kennedy D,Quinn RJ,Feng Y

    更新日期：2016-12-24 00:00:00

  • Phenylethanol glycosides from Cistanche tubulosa improved reproductive dysfunction by regulating testicular steroids through CYP450-3β-HSD pathway.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cistanche tubulosa (Schenk) R. Wight has been used frequently in traditional folk medicine for treatment of male sexual dysfunction (MSD). Phenylethanol glycosides, the main components of C. tubulosa, possess a variety of pharmacological activities due to their multiple properties. Howeve...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112500

    authors： Wang Q,Dong J,Lu W,He H,Sun X,Zhang K,Song Q,Jiang Y,Wang Y,Li C,Tu P

    更新日期：2020-04-06 00:00:00