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Skeletal muscle relaxant action of an aqueous extract of Portulaca oleracea in the rat.

Abstract：

:The aqueous extract of Portulaca oleracea produced skeletal muscle relaxation in rats following i.p. or oral administration, as assessed by the prolongation of pull-up time. The i.p. route of administration was more effective. When compared with chlordiazepoxide (20 mg/kg, i.p.), diazepam (40 mg/kg, i.p.) and dantrolene sodium (30 mg/kg, oral), the extract (200-1000 mg/kg, i.p.) proved a more effective skeletal muscle relaxant. With 1000 mg/kg i.p., 80% lethality was seen. The LD50 in an acute toxicity test in mice was 1040 mg/kg i.p.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Parry O,Okwuasaba FK,Ejike C

doi

10.1016/0378-8741(87)90002-x

subject

Has Abstract

pub_date

1987-05-01 00:00:00

pages

247-53

issue

3

eissn

0378-8741

issn

1872-7573

pii

0378-8741(87)90002-X

journal_volume

19

pub_type

杂志文章

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