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Inhibitory activity of Chrysanthemi sibirici herba extract on RBL-2H3 mast cells and compound 48/80-induced anaphylaxis.

Abstract：

:The effects of extracts from various oriental medicinal herbs on mast cell-mediated allergic reaction were investigated. Among them, Chrysanthemi sibirici herba ethanol extract exerted the potent inhibitory activity on antigen-induced degranulation in RBL-2H3 mast cells. Chrysanthemi sibirici herba dose-dependently inhibited DNP-BSA or compound 48/80-induced degranulation in RBL-2H3 mast cells, with IC(50) values of approximately 49 microg/ml and 76 microg/ml, respectively. This extract strongly suppressed compound 48/80-induced systemic anaphylaxis by 48.7% at a dose of 300 mg/kg in mice. Chrysanthemi sibirici herba also inhibited the expression of TNF-alpha and the activation of the MAP kinase, ERK1/2, which is critical for the production of inflammatory cytokines in mast cells, as indicated by the suppression of activating phosphorylation of ERK1/2. These results lead us to conclude that Chrysanthemi sibirici herba may be used clinically to treat various allergic diseases.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Lee JH,Seo JY,Ko NY,Chang SH,Her E,Park T,Lee HY,Han JW,Kim YM,Choi WS

doi

10.1016/j.jep.2004.08.023

keywords:

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

425-30

issue

2-3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(04)00407-6

journal_volume

95

pub_type

杂志文章

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