Abstract:
:The Agapanthus africanus plant is used by South African traditional healers as a phytomedicine in herbal remedies to treat pregnancy-related ailments and to augment labour. It has already been shown that an aqueous extract of A. africanus causes smooth muscle contractions in the isolated uterus and ileum preparations. In the present study, the effects of an aqueous extract of A. africanus leaves was examined on receptor systems involved in contraction of the uterine smooth muscle in order to determine the mechanism of its pharmacological effect relevant to its ethnic use to augment labour. The extract was tested on the isolated rat uterus preparation. The aqueous extract of A. africanus leaves was found to exhibit agonist activity on uterine muscarinic receptors and to promote the synthesis of prostaglandins in the oestrogenized rat uterus. Some pharmacological justification for the ethnic use of A. africanus as a herbal oxytocic in prolonged labour has been provided.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Veale DJ,Havlik I,Oliver DW,Dekker TGdoi
10.1016/s0378-8741(98)00224-4keywords:
subject
Has Abstractpub_date
1999-09-01 00:00:00pages
257-62issue
3eissn
0378-8741issn
1872-7573pii
S0378874198002244journal_volume
66pub_type
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