Abstract：
ETHNOPHARMACOLOGICAL RELEVANCE:The hip of Rosa multiflora Thunb. (HRM) has been traditionally used as a dietary supplement and a herbal remedy for the treatment of various diseases, including inflammation, osteoarthritis, rheumatoid arthritis and chronic pain, in China. The current study was to evaluate the therapeutic efficacy of the petroleum ether extractive of HRM (PEE) on type II collagen-induced rheumatoid arthritis (CIA) in male Wistar rats. In addition, the anti-inflammatory mechanism(s) of PEE on type II CIA was explored. MATERIALS AND METHODS:Rheumatoid arthritis (RA) was induced by intradermal injection of bovine type II collagen on Day 1 and Day 8. Starting from Day 13, normal rats were treated with vehicle (serving as the control group); the CIA rats were treated with vehicle (CIA group), dexamethasone (0.25mg/kg bw per day, p.o.) (a positive control), lei-gong-teng (LGT: 10mg/kg bw per day, p.o.) (a clinically used Chinese patent medicine in RA therapy) or PEE (12, 36 or 120mg/kg bw per day, p.o.) for 28 days. RESULTS AND CONCLUSIONS:PEE (120mg/kg bw per day) efficiently attenuated the severity of arthritis in the CIA rats by reducing the mean arthritis severity scores and the fore/hind paw swelling as well as reduced histological changes by decreasing the cartilage surface erosion and cartilage proteoglan depletion. PEE׳s therapeutic effect in RA may involve the inhibition of pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-6, in serum and/or the elevation of the activities of hepatic anti-oxidative enzymes including SOD, CAT and GSH-Px. However, the detailed anti-inflammatory mechanism, the main effective components and the interaction between different ingredients in PEE are still not clear and require more studies.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Wu J,Liu X,Chan CO,Mok DK,Chan SW,Yu Z,Chen Sdoi
10.1016/j.jep.2014.09.026subject
Has Abstractpub_date
2014-11-18 00:00:00pages
45-54eissn
0378-8741issn
1872-7573pii
S0378-8741(14)00680-1journal_volume
157pub_type
杂志文章abstract：:The petroleum either extract and methanol extract of the bark of Alstonia scholaris were found to be devoid of antiamalarial activity in mice infected with Plasmodium berghei. However, a dose-dependent improvement of conditions and delayed mortality amongst animals receiving methanol extract of A. scholaris was notice...
journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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更新日期：2014-02-27 00:00:00
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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