Cheongyeolsaseuptang inhibits production of TNF-alpha, IL-6 and IL-8 as well as NF-kappa B activation in human mast cells.

Abstract:

:Traditional Korean medicine, Cheongyeolsaseuptang (CYSST) has been widely applied as a treatment of rheumatoid arthritis (RA) in Korea. However, its effect in experimental models remains unknown. Recent reports suggest that in patients with RA, synovial mast cells increase in number and show signs of activation and production of cytokines. In this study, we investigated the effect of CYSST on production of cytokines by activated human mast cell line, HMC-1. When CYSST (1mg/ml) was added, the production of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8 was significantly inhibited about 37, 33.6, and 48%, respectively on phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. In addition, CYSST inhibited PMA plus A23187-induced activation of nuclear factor-kappaB. These findings may help understanding the mechanism of action of this medicine leading to control activated mast cells on inflammatory condition like RA.

journal_name

J Ethnopharmacol

authors

Kim SJ,Lee EJ,Song YS,Jeong HJ,Lee KM,Kim HR,Chae HJ,Shin TY,Kim YK,Hong SH,Kim HM

doi

10.1016/j.jep.2004.10.018

keywords:

subject

Has Abstract

pub_date

2005-02-10 00:00:00

pages

83-8

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(04)00529-X

journal_volume

97

pub_type

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