Abstract:
:Traditional Korean medicine, Cheongyeolsaseuptang (CYSST) has been widely applied as a treatment of rheumatoid arthritis (RA) in Korea. However, its effect in experimental models remains unknown. Recent reports suggest that in patients with RA, synovial mast cells increase in number and show signs of activation and production of cytokines. In this study, we investigated the effect of CYSST on production of cytokines by activated human mast cell line, HMC-1. When CYSST (1mg/ml) was added, the production of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8 was significantly inhibited about 37, 33.6, and 48%, respectively on phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. In addition, CYSST inhibited PMA plus A23187-induced activation of nuclear factor-kappaB. These findings may help understanding the mechanism of action of this medicine leading to control activated mast cells on inflammatory condition like RA.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Kim SJ,Lee EJ,Song YS,Jeong HJ,Lee KM,Kim HR,Chae HJ,Shin TY,Kim YK,Hong SH,Kim HMdoi
10.1016/j.jep.2004.10.018keywords:
subject
Has Abstractpub_date
2005-02-10 00:00:00pages
83-8issue
1eissn
0378-8741issn
1872-7573pii
S0378-8741(04)00529-Xjournal_volume
97pub_type
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