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Effects of cryptolepine alone and in combination with dipyridamole on a mouse model of arterial thrombosis.

Abstract：

:The effects of cryptolepine alone and in combination with other antiplatelet agents have been investigated using a mouse model of arterial thrombosis. Intraperitoneal premedication with crytolepine produced 25% maximal protection at 1 mg/kg while dipyridamole producedd a 20% maximal effect at 2 mg/kg. Higher doses of cryptolepine showed a reduced effect. In contrast, indomethacin and aspirin produced a dose-related and higher degree of protection. A combination of cryptolepine and dipyridamole was more effective than when the individual drugs were used alone. The use of 20% ethanol as a dosage vehicle enhanced the protective effects of all drugs tested and the ethanol vehicle alone provided 45% protection.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Oyekan AO,Okafor JP

doi

10.1016/0378-8741(89)90086-x

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

141-8

issue

1-2

eissn

0378-8741

issn

1872-7573

pii

0378-8741(89)90086-X

journal_volume

27

pub_type

杂志文章

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