Xuefuzhuyu decoction inhibition of angiogenesis attenuates liver fibrosis induced by CCl₄ in mice.


ETHNOPHARMACOLOGICAL RELEVANCE:Xuefuzhuyu decoction (XFZY) is a well-known traditional Chinese herbal formulation composed of 11 herbs. It is an effective treatment for cardiovascular and chronic liver diseases. The aim of the study is to investigate the role of XFZY on angiogensis in hepatic fibrogenesis, and identify the possible mechanism. MATERIAL AND METHODS:Liver fibrosis was induced by intraperitoneal injection of Carbon tetrachloride (CCl₄) in C57BL/6 mice for 6 weeks. From week 4 to week 6, the CCl₄-injected mice were randomly divided into three groups, followed by oral administration of Sorafenib, XFZY and water for 3 weeks. Biochemical parameters, hydroxyproline (Hyp) content and histological changes of the liver were determined. The expressions of alpha smooth muscle actin (α-SMA), collagen I, CD31 and vascular endothelial grow factor (VEGF) were assessed by immunohistochemistry and western blot. The protein expressions of VEGFR-2, hypoxia inducing factor (HIF)-1α, asymmetric dimethylarginine (ADMA) and dimethylarginine hydrolase (DDAH) 1 were determined by western blot. The mRNA levels of α-SMA, VEGF and HIF-1α were measured by RT-PCR. RESULTS:Both Sorafenib and XFZY improved biochemical parameters of the liver fibrosis mice. A significant reduction in Hyp content was found in the XFZY-treated mice as well as the Sorafenib-treated mice. Changes in histopathology showed that Sorafenib and XFZY decreased inflammatory and fibrotic stages of the liver in fibrosis mice. Compared to CCl4 model group, Sorafenib and XFZY decreased α-SMA, collagen I, CD31, VEGF, VEGFR-2, HIF-1α and ADMA, and increased the expression of DDAH1. CONCLUSION:XFZY inhibits liver fibrosis not only through inhibiting collagen deposition but also through an antiangiogenic effect on the fibrotic liver. Moreover, the antiangiogenic mechanism of XFZY involves alleviating hypoxia and protecting liver sinusoidal endothelial cell function.


J Ethnopharmacol


Zhou YN,Sun MY,Mu YP,Yang T,Ning BB,Ren S,Chen JM,Liu P




Has Abstract


2014-05-14 00:00:00














  • A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae).

    abstract:UNLABELLED:ETHNOPHARMACOLOGICAL CONTEXT: A detailed review of the ethnobotany and commercial history of Pelargonium sidoides is presented, together with a brief summary of pre-clinical and clinical scientific results that support the use of the plant in modern, evidence-based phytomedicines. The aim is to identify the ...

    journal_title:Journal of ethnopharmacology

    pub_type: 历史文章,杂志文章,评审


    authors: Brendler T,van Wyk BE

    更新日期:2008-10-28 00:00:00

  • The immunostimulatory effects and chemical characteristics of heated honey.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:In traditional Chinese medicine (TCM), honey has been used as an additive in the heat-processing of herbal medicines to enhance their immunostimulatory activities. AIM OF THE STUDY:We investigated the immunostimulatory activity of heated honey in vitro and in vivo. MATERIALS AND METHODS...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Ota M,Ishiuchi K,Xu X,Minami M,Nagachi Y,Yagi-Utsumi M,Tabuchi Y,Cai SQ,Makino T

    更新日期:2019-01-10 00:00:00

  • Antimalarial activity of cedronin.

    abstract::Cedronin was isolated from Simaba cedron Planchon (Simaroubaceae), a species popularly believed in South America to have antimalarial properties. It was examined for in vitro and in vivo antimalarial activities and for cytotoxicity against KB cells. Experimental results showed that cedronin was active against chloroqu...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Moretti C,Deharo E,Sauvain M,Jardel C,David PT,Gasquet M

    更新日期:1994-06-01 00:00:00

  • In vitro anti-glycation activity of the marine plant Posidonia oceanica (L.) Delile.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The marine plant Posidonia oceanica (L.) Delile is traditionally used by villagers of the west coast of Anatolia as a remedy for diabetes and hypertension. AIM OF THE STUDY:The aim of this study was to explore the role of the P. oceanica hydroalcoholic leaves extract (POE) against human ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Vasarri M,Barletta E,Ramazzotti M,Degl'Innocenti D

    更新日期:2020-09-15 00:00:00

  • Antihypertensive and vasorelaxant effects of aqueous extract from Croton schiedeanus Schlecht in rats.

    abstract::Antihypertensive and vasorelaxant effects of treatment with the aqueous extract of Croton schiedeanus Schlecht (AECS) were investigated in anaesthetized spontaneously hypertensive rats (SHR). Intravenous bolus injections of AECS (5-100 mg/kg) elicited dose-dependent decreases in mean arterial pressure (MAP) and heart ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Guerrero MF,Carrón R,Martín ML,San Román L,Reguero MT

    更新日期:2001-04-01 00:00:00

  • Change in medical plant use in Estonian ethnomedicine: a historical comparison between 1888 and 1994.

    abstract:AIM OF THE STUDY:The aim of this paper is to compare the changes in the utilization of species from various hemeroby categories (indicating the degree of sensitivity of the plant to human impact) using historical data concerning the years 1888-1994. MATERIALS AND METHODS:The authors digitised 8808 handwritten reports,...

    journal_title:Journal of ethnopharmacology

    pub_type: 历史文章,杂志文章


    authors: Sõukand R,Kalle R

    更新日期:2011-05-17 00:00:00

  • Preliminary screening of some tropical plants for anti-tyrosinase activity.

    abstract::In our efforts to find new active tyrosinase inhibitors for skin-whitening or antibrowning preparations, we investigated 67 tropical plants belonging to 38 families, which were evaluated for their anti-tyrosinase activity. The results of our investigation show that extracts of 5 plants, Stryphnodendron barbatimao, Por...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Baurin N,Arnoult E,Scior T,Do QT,Bernard P

    更新日期:2002-10-01 00:00:00

  • Study of pharmacokinetic profiles and characteristics of active components and their metabolites in rat plasma following oral administration of the water extract of Astragali radix using UPLC-MS/MS.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Astragali radix is one of the well-known traditional Chinese herbal medicine, and possesses various biological functions, such as hepatoprotective and anticancer. In present study, to investigate the metabolism and pharmacokinetics of the major constituents of A. radix, a sensitive ultra-...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Shi J,Zheng L,Lin Z,Hou C,Liu W,Yan T,Zhu L,Wang Y,Lu L,Liu Z

    更新日期:2015-07-01 00:00:00

  • Aqueous extract of Chrysobalanus icaco leaves, in lower doses, prevent fat gain in obese high-fat fed mice.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Due to the rise in obesity, the necessity for resources and treatments that could reduce the morbidity and mortality associated to this pandemia has emerged. The development of new anti-obesity drugs through herbal sources has been increasing in the past decades which are being used not o...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: White PA,Cercato LM,Batista VS,Camargo EA,De Lucca W Jr,Oliveira AS,Silva FT,Goes TC,Oliveira ER,Moraes VR,Nogueira PC,De Oliveira E Silva AM,Quintans-Junior LJ,Lima BS,Araújo AA,Santos MR

    更新日期:2016-02-17 00:00:00

  • Pharmacological potential and conservation prospect of the genus Eucomis (Hyacinthaceae) endemic to southern Africa.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The genus Eucomis (Hyacinthaceae) consists of 10 species that are extensively used in African traditional medicine. This review is an appraisal of current information on the distribution and morphology, traditional uses, pharmacology, toxicology and approaches devised to enhance the conse...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审


    authors: Masondo NA,Finnie JF,Van Staden J

    更新日期:2014-01-01 00:00:00

  • Antioxidant activity of a salt-spice-herbal mixture against free radical induction.

    abstract::A combination of spices (Piper nigrum, Piper longum and Zingiber officinale), herbs (Cyperus rotundus and Plumbago zeylanica) and salts make up Amrita Bindu. The study was focused to evaluate the antioxidant property of individual ingredients in Amrita Bindu against the free radical 2,2'-azinobis-(3-ethylbenzothiazoli...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Natarajan KS,Narasimhan M,Shanmugasundaram KR,Shanmugasundaram ER

    更新日期:2006-04-21 00:00:00

  • Guarana (Paullinia cupana): toxic behavioral effects in laboratory animals and antioxidants activity in vitro.

    abstract::The effects on toxic and behavioral levels of guarana (Paullinia cupana) were assessed in rats and mice subsequent to acute and chronic administrations and were compared to those produced by Ginseng (Panax ginseng). Experimental parameters included tests for antioxidant capacity in vitro and measured in vivo, toxicolo...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Mattei R,Dias RF,Espínola EB,Carlini EA,Barros SB

    更新日期:1998-03-01 00:00:00

  • Chrysoeriol and other polyphenols from Tecoma stans with lipase inhibitory activity.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Tecoma stans is traditionally used by several ethnical groups in Mexico and Central America to treat diabetes. This species is mentioned in the majority of the ethnopharmacological studies compiled in Mexico focused in medicinal plants used as anti-diabetic treatment. AIM OF THE STUDY:Re...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Ramirez G,Zamilpa A,Zavala M,Perez J,Morales D,Tortoriello J

    更新日期:2016-06-05 00:00:00

  • Traditional pharmaceutical practice in Gondar region, northwestern Ethiopia.

    abstract::The knowledge and skills of Ethiopian traditional healers in Gondar region on the pharmaceutical aspects of their practice were assessed using a questionnaire. Of the 86 healers interviewed, only 83 gave responses good enough to be considered in the analysis of results. It was shown that the healers obtained their dru...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Abebe W

    更新日期:1984-06-01 00:00:00

  • Cytotoxicity and modes of action of five Cameroonian medicinal plants against multi-factorial drug resistance of tumor cells.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Beilschmiedia acuta Kosterm, Clausena anisata (Willd) Hook, Fagara tessmannii Engl., Newbouldia laevis Seem., and Polyscias fulva (Hiern) Harms. are medicinal plants used in Cameroonian traditional medicine in the treatment of various types of cancers. The present study aims at investigat...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Kuete V,Tankeo SB,Saeed ME,Wiench B,Tane P,Efferth T

    更新日期:2014-04-11 00:00:00

  • Traditional Chinese Medicine formula FTZ protects against polycystic ovary syndrome through modulating adiponectin-mediated fat-ovary crosstalk in mice.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:FuFang ZhenZhu TiaoZhi (FTZ) is a hospitalized traditional Chinese medicine herbal formula with documented metabolic benefits. Polycystic ovary syndrome (PCOS) characterized by ovarian dysfunction and insulin resistance represents one of the most common endocrine disorders in close associ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Xu Y,Tang J,Guo Q,Xu Y,Yan K,Wu L,Xie K,Zhu A,Rong X,Ye D,Guo J

    更新日期:2021-03-25 00:00:00

  • The plasma glucose lowering action of Hei-Shug-Pian, the fire-processed product of the root of Aconitum (Aconitum carmichaeli), in streptozotocin-induced diabetic rats.

    abstract::The anti-hyperglycemic action of Hei-Shug-Pian, the fire-processed product of the root of Aconitum (Aconitum carmichaeli), was investigated in streptozotocin-induced diabetic (STZ-diabetic) rats. At 120 min following oral administration of Hei-Shug-Pian at doses ranging from 12.5 to 50 mg/kg, plasma glucose of STZ-dia...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Liou SS,Liu IM,Lai MC

    更新日期:2006-06-30 00:00:00

  • Folk medical uses of plant foods in southern Appalachia, United States.

    abstract::An analysis of information obtained from interviews with 660 older native inhabitants of the southern Appalachian region in the United States indicates that plant foods, especially cultivars and materials processed from them, and some wildcrafted plant foods as well, constituted the bulk of the folk materia medica in ...

    journal_title:Journal of ethnopharmacology

    pub_type: 历史文章,杂志文章


    authors: Cavender A

    更新日期:2006-11-03 00:00:00

  • Ethnoveterinary knowledge and practices at Colares Island, Pará state, eastern Amazon, Brazil.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The lack of ethnoveterinary surveys in Brazil, especially in the Amazon region, results in losses in the veterinary phytopharmacology field and in scientific documentation of the cultural traditions of plant use in the treatment of animal diseases. AIM OF THE STUDY:To catalog, analyze an...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Ritter RA,Monteiro MV,Monteiro FO,Rodrigues ST,Soares ML,Silva JC,Palha Md,Biondi GF,Rahal SC,Tourinho MM

    更新日期:2012-11-21 00:00:00

  • Establishment of an in vitro system based on AGM-S3 co-culture for screening traditional herbal medicines that stimulate hematopoiesis.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Spatholobus suberectus Dunn is a traditional Chinese medicine (TCM) that can activate blood, dispel stasis, inhibit platelet aggregation, and stimulate hematopoiesis, and thereby treat anemia and diseases related to blood stasis syndrome (BSS). However, its hematopoiesis-stimulating activ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Chang J,Sun W,Zeng J,Xue Y,Zhang Y,Pan X,Zhou Y,Lai M,Bian G,Zhou Q,Liu J,Chen B,Guo F,Ma F

    更新日期:2019-08-10 00:00:00

  • Antidiarrhoeal activity of Waltheria americana, Commelina coelestis and Alternanthera repens.

    abstract::The antidiarrhoeal activity of the hexane, chloroform, methanol and aqueous extracts of Waltheria americana, Commelina coelestis and Alternathera repens, was tested on mice with diarrhoea induced by castor oil and MgSO4. The methanol extract of C. coelestis and A. repens and aqueous extract of A. repens, presented ant...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Zavala MA,Pérez S,Pérez C,Vargas R,Pérez RM

    更新日期:1998-05-01 00:00:00

  • Characterization and immunostimulating effects on murine peritoneal macrophages of oligosaccharide isolated from Panax ginseng C.A. Meyer.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Panax ginseng C.A. Meyer has been the most precious and renowned Chinese herb used in Asian countries for the treatment of various medical disorders. AIM OF THE STUDY:The aim of this work was to investigate the activation effect on murine peritoneal macrophages of oligosaccharide from th...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Jiao L,Wan D,Zhang X,Li B,Zhao H,Liu S

    更新日期:2012-12-18 00:00:00

  • UHPLC/Q-TOFMS-based metabolomics for the characterization of cold and hot properties of Chinese materia medica.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The cold/hot property of Chinese materia medica (CMM) and the application of its corresponding knowledge in the diagnosis, differentiation and treatment of diseases have been considered to be the extremely important part of traditional Chinese medicine (TCM). As highly abstracted TCM theo...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Wang Y,Zhou S,Wang M,Liu S,Hu Y,He C,Li P,Wan JB

    更新日期:2016-02-17 00:00:00

  • Inhibition of biofilm and quorum sensing-regulated virulence factors in Pseudomonas aeruginosa by Cuphea carthagenensis (Jacq.) J. F. Macbr. Leaf extract: An in vitro study.

    abstract:ETHNOPHARMCOLOGICAL RELEVANCE:Microbial biofilm formation, a quorum sensing (QS) regulated process, is one of the major causes of nosocomial and chronic infections, foodborne diseases, and associated deaths. Various approaches have been used to eradicate the menace of biofilm. Ethnomedicinal plants as potent antibiofil...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Rather MA,Gupta K,Mandal M

    更新日期:2021-04-06 00:00:00

  • Ethanolic extract of Cordyceps cicadae exerts antitumor effect on human gastric cancer SGC-7901 cells by inducing apoptosis, cell cycle arrest and endoplasmic reticulum stress.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Cordyceps cicadae (Miq.) Massee is a traditional Chinese medicine that has been used for approximately 1600 years in China. C. cicadae, a member of the Cordyceps genus, exerts a therapeutic effect on many diseases, such as cancer. OBJECTIVE:This study aimed to evaluate the antineoplasmic...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Xie H,Li X,Chen Y,Lang M,Shen Z,Shi L

    更新日期:2019-03-01 00:00:00

  • Antihypertensive action of a procyanidin glycoside from Rhamnus lycioides.

    abstract::The antihypertensive action of a procyanidin glycoside isolated from Rhamnus lycioides aerial parts was studied in spontaneously and renal hypertensive rats. This compound, like 20 micrograms/kg i.v. of captopril, produced a very clear in vivo inhibition of angiotensin I converting enzyme when given at a dose of 3 mg/...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Terencio MC,Sanz MJ,Paya M

    更新日期:1991-01-01 00:00:00

  • Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis.

    abstract:AIM OF THE STUDY:Sinomenine, an alkaloid isolated from the root of Sinomenium acutum, has been used to alleviate the symptoms of rheumatic diseases. Liang Miao San (LMS), composed of the herbs Rhizoma Atractylodis (Cangzhu) and Cotex Phellodendri (Huangbai), is another traditional Chinese medicine formula for rheumatoi...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Chen DP,Wong CK,Leung PC,Fung KP,Lau CB,Lau CP,Li EK,Tam LS,Lam CW

    更新日期:2011-09-01 00:00:00

  • Evaluation of antidiarrhoeal activity Rumex maritimus root.

    abstract::The partitioned n-hexane, ethylacetate and residual methanol extracts of the root of Rumex maritimus were evaluated for antidiarrhoeal activity in mice using castor oil and serotonin induced diarrhoea and also charcoal motility test at 50, 100 and 200 mg/kg body weight dose. Among these, the methanol extract most sign...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Rouf AS,Islam MS,Rahman MT

    更新日期:2003-02-01 00:00:00

  • Angiogenic efficacy of simplified 2-herb formula (NF3) in zebrafish embryos in vivo and rat aortic ring in vitro.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Diabetic foot ulceration results in high risk of lower extremity amputation, and represents a significant health care expenditure worldwide. Radix Astragali (RA) and Radix Rehmanniae (RR) are widely used Chinese medicinal herbs in treating diabetes, and have shown positive effects in enha...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Tse HY,Hui MN,Li L,Lee SM,Leung AY,Cheng SH

    更新日期:2012-01-31 00:00:00

  • In vitro immunomodulating properties of selected Sudanese medicinal plants.

    abstract::Ethanolic extracts of 23 medicinal plants, commonly used in Sudanese folk medicines against infectious diseases, were investigated for their immunomodulating activity using luminol/lucigenin-based chemiluminescence assay. Preliminary screenings on whole blood oxidative burst activity showed inhibitory activities of 14...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Koko WS,Mesaik MA,Yousaf S,Galal M,Choudhary MI

    更新日期:2008-06-19 00:00:00