Xuefuzhuyu decoction inhibition of angiogenesis attenuates liver fibrosis induced by CCl₄ in mice.


ETHNOPHARMACOLOGICAL RELEVANCE:Xuefuzhuyu decoction (XFZY) is a well-known traditional Chinese herbal formulation composed of 11 herbs. It is an effective treatment for cardiovascular and chronic liver diseases. The aim of the study is to investigate the role of XFZY on angiogensis in hepatic fibrogenesis, and identify the possible mechanism. MATERIAL AND METHODS:Liver fibrosis was induced by intraperitoneal injection of Carbon tetrachloride (CCl₄) in C57BL/6 mice for 6 weeks. From week 4 to week 6, the CCl₄-injected mice were randomly divided into three groups, followed by oral administration of Sorafenib, XFZY and water for 3 weeks. Biochemical parameters, hydroxyproline (Hyp) content and histological changes of the liver were determined. The expressions of alpha smooth muscle actin (α-SMA), collagen I, CD31 and vascular endothelial grow factor (VEGF) were assessed by immunohistochemistry and western blot. The protein expressions of VEGFR-2, hypoxia inducing factor (HIF)-1α, asymmetric dimethylarginine (ADMA) and dimethylarginine hydrolase (DDAH) 1 were determined by western blot. The mRNA levels of α-SMA, VEGF and HIF-1α were measured by RT-PCR. RESULTS:Both Sorafenib and XFZY improved biochemical parameters of the liver fibrosis mice. A significant reduction in Hyp content was found in the XFZY-treated mice as well as the Sorafenib-treated mice. Changes in histopathology showed that Sorafenib and XFZY decreased inflammatory and fibrotic stages of the liver in fibrosis mice. Compared to CCl4 model group, Sorafenib and XFZY decreased α-SMA, collagen I, CD31, VEGF, VEGFR-2, HIF-1α and ADMA, and increased the expression of DDAH1. CONCLUSION:XFZY inhibits liver fibrosis not only through inhibiting collagen deposition but also through an antiangiogenic effect on the fibrotic liver. Moreover, the antiangiogenic mechanism of XFZY involves alleviating hypoxia and protecting liver sinusoidal endothelial cell function.


J Ethnopharmacol


Zhou YN,Sun MY,Mu YP,Yang T,Ning BB,Ren S,Chen JM,Liu P




Has Abstract


2014-05-14 00:00:00














  • Abortifacient potential of methanolic extract of Anthocephalus cadamba stem bark in mice.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants possessing abortifacient activity have been used traditionally for a long time in folk medicine. Anthocephalus cadamba, is one such herb that has been known to possess abortifacient potential in ethnobotanical literature, but has not been validated scientifically. MATERI...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Shaikh MV,Kala M,Ravat N,Nivsarkar M

    更新日期:2015-09-15 00:00:00

  • Evaluation of some pharmacological activities of Eugenia uniflora L.

    abstract::In view of the extensive use of Eugenia uniflora in folk medicine, different extracts of dried and fresh leaves of the plant were assayed to test its possible pharmacological activities. The infusion of fresh leaves had a highly significant anti-inflammatory effect when administered p.o. to rats 1 h before subplantar ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Schapoval EE,Silveira SM,Miranda ML,Alice CB,Henriques AT

    更新日期:1994-12-01 00:00:00

  • Effects of the total flavonoid extract of Xiaobuxin-Tang on depression-like behavior induced by lipopolysaccharide and proinflammatory cytokine levels in mice.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Xiaobuxin-Tang (XBXT), a traditional Chinese herbal decoction, has been used for the treatment of depressive disorders from ancient clinic. The aim of the study was to explore the involvement of inflammation or inflammatory markers in the antidepressant-like effects of XBXT-2. MATERIALS ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: An L,Li J,Yu ST,Xue R,Yu NJ,Chen HX,Zhang LM,Zhao N,Li YF,Zhang YZ

    更新日期:2015-04-02 00:00:00

  • Hypoglycemic effect of Malmea depressa root on streptozotocin diabetic rats.

    abstract::The hypoglycemic effects of water, ethanolic and butanolic extracts prepared from the root of Malmea depressa (Baill) R.E. Fries. (Annonaceae) were studied in diabetic rats (streptozotocin induced). Oral application of water extracts at doses of 40 and 80 mg/kg, ethanolic (112 mg/kg) and butanolic (80 mg/kg) extracts ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Andrade-Cetto A,Martínez-Zurita E,Wiedenfeld H

    更新日期:2005-09-14 00:00:00

  • Antidepressant effect of Shudihuang on mice exposed to unpredictable chronic mild stress.

    abstract:AIM OF THE STUDY:Depression is a severe mood disorder. It was treated with Shudihuang, the steamed roots of Rehmannia glutinota Libosch. (SRG), in traditional Chinese medicine. The present paper was designed to verify its antidepressant effect. MATERIALS AND METHODS:A mouse model of depression was established though u...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Zhang D,Wen XS,Wang XY,Shi M,Zhao Y

    更新日期:2009-05-04 00:00:00

  • Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Ginkgo biloba L. (Ginkgoaceae) has been widely used in traditional medicine for variety of neurological conditions particularly behavioral and memory impairments. AIM OF THE STUDY:The present study was envisaged to explore the effect of a standardized fraction of Ginkgo biloba leaves (GB...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Mazumder AG,Sharma P,Patial V,Singh D

    更新日期:2017-05-23 00:00:00

  • Preventive effect of traditional herbal formulae against experimental hypercholesterolemia in rats with special reference to blood lipoprotein cholesterol levels.

    abstract::To investigate the effect of traditional herbal formulae (Zhong Yao) against experimental hypercholesterolemia, we assayed serum lipoprotein levels and hepatic function in rats administered herbal formulae under cholesterol rich diet. Two kinds of herbal formulae; prescription 1 (Bupleurum chinense and other 9 kinds o...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Cheng BJ,Moritomo A,Yamasaki Y,Wu LX,Inagaki M,Nishimura M,Tanishima K,Poracova J

    更新日期:2004-10-01 00:00:00

  • Anti-inflammatory effects of ethanolic extract and alkamides-derived from Heliopsis longipes roots.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Heliopsis longipes (A. Gray) Blake (Asteraceae) is a broadly used species in the Mexican, Central and South American Traditional Medicine for its anaesthetic, analgesic, anti-inflammatory and anti-ulcerative properties. The ethanolic extract contains alkamides, mainly affinin (spilanthol)...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Hernández I,Márquez L,Martínez I,Dieguez R,Delporte C,Prieto S,Molina-Torres J,Garrido G

    更新日期:2009-07-30 00:00:00

  • Effects of Hemerocallis flava on motor activity and the concentration of central monoamines and its metabolites in rats.

    abstract::In this study, we used behavioral and biochemical methods to investigate the effects of Hemerocallis flava (Liliaceae) (abbreviated as HF) on motor activity and the concentration of monoamines in rats. The water fraction of the resuspended HF extract was most active in reducing the motility in rats. The water fraction...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Hsieh MT,Ho YF,Peng WH,Wu CR,Chen CF

    更新日期:1996-06-01 00:00:00

  • Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats.

    abstract:AIM OF THE STUDY:Rhei Rhizoma, the rhizome of Rheum palmatum L. (RP), is a popular herb in clinical Chinese medicine. RP is abundant in polyphenolic anthraquinones, which have been reported to show various beneficial bioactivities. This study investigated the pharmacokinetics and tissue distribution of anthraquinones f...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Shia CS,Tsai SY,Lin JC,Li ML,Ko MH,Chao PD,Huang YC,Hou YC

    更新日期:2011-10-11 00:00:00

  • Evaluation of the toxicity potential of acute and sub-acute exposure to the aqueous root extract of Aristolochia ringens Vahl. (Aristolochiaceae).

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Aristolochia ringens Vahl. (Aristolochiaceae) is used traditionally in Nigeria for managing a number of ailments including gastrointestinal disturbances, rheumatoid arthritis, pile, insomnia, oedema, and snake bite venom. Some studies in our laboratory have demonstrated a scientific justi...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Aigbe FR,Sofidiya OM,James AB,Sowemimo AA,Akindere OK,Aliu MO,Dosunmu AA,Chijioke MC,Adeyemi OO

    更新日期:2019-11-15 00:00:00

  • Inhibitory effect of Streblus asper leaf-extract on adhesion of Candida albicans to denture acrylic.

    abstract::This in vitro study aimed at determining the effects of various sublethal concentrations of Streblus asper leaf ethanolic extract (SAE) on adherence of Candida albicans to acrylic surface. A colorimetric tetrazolium assay using (2,3)-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)-carbonyl]-2H-tetrazolium hydro...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Taweechaisupapong S,Klanrit P,Singhara S,Pitiphat W,Wongkham S

    更新日期:2006-07-19 00:00:00

  • Hypoglycaemic effect of spergularia purpurea in normal and streptozotocin-induced diabetic rats.

    abstract::Single and repeated oral administration of the water extracts of Spergularia purpurea (SP) at a dose of 10 mg/kg were tested on hypoglycaemic activity in normal and streptozotocin-induced diabetic rats. In normal rats, the water extract of SP decreased significantly the plasma glucose levels 4 h after single oral admi...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Jouad H,Eddouks M,Lacaille-Dubois MA,Lyoussi B

    更新日期:2000-07-01 00:00:00

  • Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis.

    abstract:AIM OF THE STUDY:Sinomenine, an alkaloid isolated from the root of Sinomenium acutum, has been used to alleviate the symptoms of rheumatic diseases. Liang Miao San (LMS), composed of the herbs Rhizoma Atractylodis (Cangzhu) and Cotex Phellodendri (Huangbai), is another traditional Chinese medicine formula for rheumatoi...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Chen DP,Wong CK,Leung PC,Fung KP,Lau CB,Lau CP,Li EK,Tam LS,Lam CW

    更新日期:2011-09-01 00:00:00

  • Indian freshwater edible snail Bellamya bengalensis lipid extract prevents T cell mediated hypersensitivity and inhibits LPS induced macrophage activation.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Soup prepared from the foot of fresh water edible snail, Bellamya bengalensis, is traditionally consumed by the tribes of Jharkhand against rheumatism like bone and joint inflammation. As rheumatism has underlying involvement of cell mediated hypersensitivity, in vivo delayed-type hyperse...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Bhattacharya S,Chakraborty M,Bose M,Mukherjee D,Roychoudhury A,Dhar P,Mishra R

    更新日期:2014-11-18 00:00:00

  • Biological screening of traditional medicinal plants from Papua New Guinea.

    abstract::Based on ethnopharmacological literature, 17 species of medicinal plants used in the traditional medicine in Papua New Guinea were collected. Extracts of different polarities were tested in a preliminary biological screening for their antimicrobial (Escherichia coli, Bacillus subtilis, Micrococcus luteus and Penicilli...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Nick A,Rali T,Sticher O

    更新日期:1995-12-15 00:00:00

  • Global medicinal uses of Euphorbia L. (Euphorbiaceae).

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The genus Euphorbia (spurges, Euphorbiaceae) is the third largest genus of flowering plants, with almost 2000 species. Its exceptional diversity of growth forms and near-cosmopolitan distribution have attracted human interest since ancient times. For instance in Australia, topical applica...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审


    authors: Ernst M,Grace OM,Saslis-Lagoudakis CH,Nilsson N,Simonsen HT,Rønsted N

    更新日期:2015-12-24 00:00:00

  • Screening of some medicinal plants for anti-lipase activity.

    abstract::In order to find new pancreatic lipase (triacylglycerol lipase, EC inhibitors from natural sources, 75 medicinal plants belonging to different families were screened for their anti-lipase activity, using a radioactive method. On evaluating the results, methanolic extracts of three plants namely, Eriochloa vil...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Sharma N,Sharma VK,Seo SY

    更新日期:2005-03-21 00:00:00

  • Ethnopharmacological survey of medicinal herbs in Jordan, the Ajloun Heights region.

    abstract::The study of local knowledge about natural resources is becoming increasingly important in defining strategies and actions for conservation of medicinal plants. This study therefore sought to collect information from local population concerning the use of Ajloun Heights region medicinal plants; identify the most impor...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Aburjai T,Hudaib M,Tayyem R,Yousef M,Qishawi M

    更新日期:2007-03-21 00:00:00

  • An ethnopharmacological assessment of the use of plants against parasitic diseases in humans and animals.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Ethnobotanical surveys are detecting an increasing frequency of exotic plant species in pharmacopeias, which has led researchers to investigate the role of such species in traditional medical systems. According to the diversification hypothesis, exotic species are included to complete pha...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Silva Fdos S,Albuquerque UP,Costa Júnior LM,Lima Ada S,do Nascimento AL,Monteiro JM

    更新日期:2014-09-11 00:00:00

  • Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita.

    abstract:AIM OF THE STUDY:Artemisia vestita is a common traditional Tibetan medicinal plant which has been used widely in China for treating various inflammatory diseases. Since little is known about its active components, the purpose of this study was to isolate and identify the immunosuppressive compounds from Artemisia vesti...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Yin Y,Gong FY,Wu XX,Sun Y,Li YH,Chen T,Xu Q

    更新日期:2008-10-30 00:00:00

  • Impressic acid from Acanthopanax koreanum, possesses matrix metalloproteinase-13 down-regulating capacity and protects cartilage destruction.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Acanthopanax koreanum (Araliaceae) has been used in traditional medicine for enhancing vitality, rheumatism, and bone-related pains. But its activity on cartilage protection has not been known yet. AIM OF THE STUDY:Matrix metalloproteinase (MMP)-13 has an important role in degrading cart...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Lim H,Min DS,Yun HE,Kim KT,Sun YN,Dat LD,Kim YH,Kim HP

    更新日期:2017-09-14 00:00:00

  • Genotoxicity of Brosimum gaudichaudii measured by the Salmonella/microsome assay and chromosomal aberrations in CHO cells.

    abstract::The root bark of Brosimum gaudichaudii Trécul (Moraceae) is popularly used for treatment of vitiligo. In the present study the mutagenic activity of the aqueous and methanolic extract as well as of the n-butanolic fraction of this medicinal plant were evaluated using Salmonella typhimurium assays, TA100, TA98, TA102 a...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Varanda EA,Pozetti GL,Lourenço MV,Vilegas W,Raddi MS

    更新日期:2002-07-01 00:00:00

  • Chinese materia medica used in medicinal diets.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal diets have a history of more than 2000 years. Locally referred to as yaoshan (Chinese: ), a medicinal diet is understood in China as a dietary product that combines herbs and food with the purpose of preventing and treating diseases or improving health under the guidance of trad...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Tan F,Chen Y,Tan X,Ma Y,Peng Y

    更新日期:2017-07-12 00:00:00

  • In vivo antimalarial activities of extracts from Amaranthus spinosus L. and Boerhaavia erecta L. in mice.

    abstract::Extracts obtained from two Burkinabe folk medicine plants, spiny amaranth (Amaranthus spinosus L., Amaranthaceae) and erect spiderling (Boerhaavia erecta L., Nyctagynaceae) were screened for antimalarial properties with the aim of testing the validity of their traditional uses. The plant extracts showed significant an...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Hilou A,Nacoulma OG,Guiguemde TR

    更新日期:2006-01-16 00:00:00

  • Antihepatotoxic actions of gingerols and diarylheptanoids.

    abstract::The antihepatotoxic effects of gingerols, shogaols, diarylheptanoids and related analogues were assessed utilizing carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Most congeners exhibited significant actions in these assay methods. The carbon tetrachloride assay appear...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Hikino H,Kiso Y,Kato N,Hamada Y,Shioiri T,Aiyama R,Itokawa H,Kiuchi F,Sankawa U

    更新日期:1985-09-01 00:00:00

  • Anti-nociceptive and anti-inflammatory effects of the ethanol extract of Arenga pinnata (Wurmb) Merr. fruit.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Arenga pinnata (Wurmb) Merr. is a medicinal and edible plant belonging to family Palmae. The fruits of this plant were used in traditional folk medicine due to its analgesia and anti-inflammatory activities. This study aimed to investigate the analgesic and anti-inflammatory properties an...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Li F,Huo J,Zhuang Y,Xiao H,Wang W,Huang L

    更新日期:2020-02-10 00:00:00

  • Antidiabetic activities of entagenic acid in type 2 diabetic db/db mice and L6 myotubes via AMPK/GLUT4 pathway.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Entada phaseoloides (L.) Merr., a traditional Chinese folk medicine, has been used in treating diabetes and other inflammatory disorders. Our previous study revealed that the triterpene saponins in E.Phaseoloides possessed an antidiabetic effect in type 2 diabetic rats by activating AMP-a...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Xiong H,Zhang S,Zhao Z,Zhao P,Chen L,Mei Z

    更新日期:2018-01-30 00:00:00

  • Reconstruction of the inventory of materia medica used by members of the Jewish community of medieval Cairo according to prescriptions found in the Taylor-Schechter Genizah collection, Cambridge.

    abstract::The Taylor-Schechter (T-S) collection at Cambridge University Library is the biggest of all Cairo Genizah collections in the world. The importance and the potential of research into the medical aspects of the Genizah documents were clear to researcher since the early 1960s. A few works have been published since, usual...

    journal_title:Journal of ethnopharmacology

    pub_type: 历史文章,杂志文章


    authors: Lev E,Amar Z

    更新日期:2006-12-06 00:00:00

  • Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus.

    abstract::Prunus persica L. BATSCH seed-water extract (PPE) has been used in the treatment of the degenerative disorders, such as hypermenorrhea and dysmenorrhea, in Taiwan, China, Japan and Korea. In this study, the effects of oral administration of PPE on the extracellular acetylcholine concentration in the hippocampus of rat...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章


    authors: Kim YK,Koo BS,Gong DJ,Lee YC,Ko JH,Kim CH

    更新日期:2003-08-01 00:00:00