Abstract：
:The present study evaluated the chemical composition and the antimicrobial activity of the extracts and fractions of Mikania laevigata and Mikania glomerata on growth and cell adherence of mutans streptococci. Ethanolic extract, hexane and ethyl acetate fractions of Mikania laevigata and Mikania glomerata were chemically identified by chromatographic methods and tested on mutans streptococci from culture collection and clinical isolates. Twenty-two compounds were identified in both Mikania extracts, including coumarin, 1-octadecene, and diterpenic, cupressenic and kaurenoic acids. Antimicrobial activity was assessed by determination of the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and inhibition of cell adherence to a glass surface. Hexane fraction from both plant extracts was the most effective in inhibiting the growth of the bacterial strains tested (MIC values between 12.5 microg/ml and 400 microg/ml, and MBC values between 25 microg/ml and 400 microg/ml). In addition, sub-MIC levels of the crude extracts and their hexane fractions significantly inhibited the adherence of the microorganisms to a glass surface. The data indicate that the biologically active compounds are present mostly in the hexane fraction of both Mikania species, which showed remarkable inhibitory activities against mutans streptococci. Mikania genus plant is a promising source for novel antimicrobial agents against oral pathogens.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Yatsuda R,Rosalen PL,Cury JA,Murata RM,Rehder VL,Melo LV,Koo Hdoi
10.1016/j.jep.2004.09.042keywords:
subject
Has Abstractpub_date
2005-02-28 00:00:00pages
183-9issue
2eissn
0378-8741issn
1872-7573pii
S0378-8741(04)00496-9journal_volume
97pub_type
杂志文章abstract：:Withering's (1741-1799) greatest merit is not so much that of having discovered the therapeutic value of foxglove in hydropsy, since this indication (among others) was already part of traditional medicine, but actually during a decade of carefully recording clinical observations, he authoritatively settled definite gu...
journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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更新日期：2010-08-09 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2021-03-25 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2002-12-01 00:00:00
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：1986-02-01 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2016-07-21 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2011-09-01 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2015-03-13 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In Tanzania, traditional medicine plays a significant role in health care and local economies based on the harvesting, trade and sale of medicinal plant products. The majority of this plant material is said to originate from wild sources, and both traditional healers and vendors are conce...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2018-08-10 00:00:00
