Relaxant effects of the essential oil of Ocimum gratissimum on isolated ileum of the guinea pig.

Abstract:

:The effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) on guinea pig ileum were studied. EOOG (0.1-1000 microg/ml) reversibly and concentration-dependently relaxed the basal tone of the ileum and reversed the tonic contractions induced by 60 mM KCl and 10 microM acetylcholine, with IC(50) values of 23.8+/-5.2, 18.6+/-4.0 and 70.0+/-4.6 microg/ml, respectively. Our results show that EOOG exerts relaxant effects on intestinal smooth muscle, consistent with the popular use of the plant to treat gastrointestinal disorders.

journal_name

J Ethnopharmacol

authors

Madeira SV,Matos FJ,Leal-Cardoso JH,Criddle DN

doi

10.1016/s0378-8741(02)00049-1

keywords:

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

1-4

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378874102000491

journal_volume

81

pub_type

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