Abstract：
ETHNOPHARMACOLOGICAL RELEVANCE:Bojungikki-tang is a traditional herbal medicine used to boost immunity and reduce fatigue. However, there is not enough scientific evidence about its toxicological safety profile to support its continued clinical application. AIM OF THE STUDY:The objective of this study was to investigate the subchronic toxicity profile of Bojungikki-tang water extract (BITW) in Sprague Dawley rats who were exposed to it in multiple doses and various concentrations. MATERIALS AND METHODS:BITW was administered to rats orally, once daily at doses of 0, 500, 1000, or 2000 mg/kg/day for 13 weeks. We checked toxicological parameters including general observations, organ/body weights, food consumption, ophthalmological signs, hematological and serum biochemical values, urinalysis values and histopathological findings. RESULTS:The 13 week repeated oral administration of BITW to rats at doses at doses levels of less than or equal to 2000 mg/kg/day caused no significant toxicological changes and only minor nonsignificant changes. CONCLUSIONS:Our findings indicate that administration of BITW for up to 13 weeks may be safe and nontoxic, with a no-observed-adverse-effect-level of >2000 mg/kg/day for both male and female rats.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Jeon WY,Seo CS,Ha H,Shin HK,Cho JW,Kim DH,Lee MYdoi
10.1016/j.jep.2020.112551subject
Has Abstractpub_date
2020-04-24 00:00:00pages
112551eissn
0378-8741issn
1872-7573pii
S0378-8741(19)33153-8journal_volume
252pub_type
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