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On the anti-inflammatory and anti-phospholipase A(2) activity of extracts from lanostane-rich species.

Abstract：

:We have studied extracts from three species rich in lanostane triterpenes for their activity against different in vivo models of inflammation induced by TPA, EPP and PLA(2). The inhibitory effect against PLA(2) in vitro was also studied. When the Poria cocos extract was tested against PLA(2)-induced mouse paw edema, it was active by the oral and parenteral routes. Its effect was greater in both magnitude and duration than that of Pistacia terebinthus and Ganoderma lucidum extracts. P. terebinthus was effective against chronic and acute inflammation, and according to a preliminary chromatographic analysis, its seems to be a good source of lanostane anti-inflammatory agents. G. lucidum was the least effective of the three species studied and, unlike the other two, failed to inhibit the activity of PLA(2) in vitro.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Giner-Larza EM,Máñez S,Giner-Pons RM,Carmen Recio M,Ríos JL

doi

10.1016/s0378-8741(00)00276-2

keywords:

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

61-9

issue

1-2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(00)00276-2

journal_volume

73

pub_type

杂志文章

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