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Preventive effect of Ophiopogon japonicus polysaccharides on an autoallergic mouse model for Sjogren's syndrome by regulating the Th1/Th2 cytokine imbalance.

Abstract：

AIM OF STUDY:Sjogren's syndrome (SS) is an autoimmune disorder characterized by lymphocytic infiltration of salivary and lacrimal glands leading to xerostomia and keratoconjunctivitis sicca. Evidence has accumulated suggesting that a Th1/Th2 cytokine imbalance has a role in the pathogenesis of SS. Currently, only palliative treatment is available. Ophiopogon japonicus, a common Chinese herbal, has been used to treat sicca-associated disorders in traditional Chinese medicine for centuries. MATERIALS AND METHOD:In this study, we constructed an autoallergic mouse model for SS by immunizing C57BL/6 mouse with submandibular gland (SMG) autoantigen. At the same time, Ophiopogon japonicus polysaccharides (OJP) was administered and hydroxychloroquine was served as positive control. During the 4 weeks' experiment, salivary flow rates were determined every week, body weight, food and water intake were measured every 2 days. After death, serum were collected for IFN-gamma and IL-4 ELISA analysis and the IFN-gamma/IL-4 was calculated, SMG and spleen were harvested for organ index calculation, and part of SMG was examined for histological changes. RESULTS:Results showed that immunization with SMG autoantigen induced decreased salivary flow and body weight, increased water intake, SMG index, spleen index, IFN-gamma level and IFN-gamma/IL-4 ratio compared with the normal group. However, administration of the OJP could improve these data and the pathological changes of SMG with respect to the model mice, especially the high-dose of OJP group. CONCLUSIONS:Thus, this study provided a basis for the use of Ophiopogon japonicus in SS.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Wang Y,Yan T,Shen J,Guo H,Xiang X

doi

10.1016/j.jep.2007.08.014

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

246-53

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(07)00389-3

journal_volume

114

pub_type

杂志文章

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