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Anticancer effects of ethanolic neem leaf extract on prostate cancer cell line (PC-3).

Abstract：

:Prostate cancer (PC) is the most prevalent cancer and the leading cause of male cancer death. Azadirachta indica (neem tree) has been used successfully centuries to reduce tumors by herbalists throughout Southeast Asia. Here the present study indicated that an ethanolic extract of neem has been shown to cause cell death of prostate cancer cells (PC-3) by inducing apoptosis as evidenced by a dose-dependent increase in DNA fragmentation and a decrease in cell viability. Western blot studies indicated that treatment with neem extract showed decreased level of Bcl-2, which is anti-apoptotic protein and increased the level of Bax protein. So the neem extract could be potentially effective against prostate cancer treatment.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Kumar S,Suresh PK,Vijayababu MR,Arunkumar A,Arunakaran J

doi

10.1016/j.jep.2005.11.006

keywords:

subject

Has Abstract

pub_date

2006-04-21 00:00:00

pages

246-50

issue

1-2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(05)00769-5

journal_volume

105

pub_type

杂志文章

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