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Puerarin attenuates glutamate-induced neurofilament axonal transport impairment.

Abstract：

AIM OF THE STUDY:Puerarin (Pur) is a primary component of the most functional extracts of Pueraria lobata used in traditional Chinese medicine for centuries. Since it has been postulated that Pur protects the brain against glutamate (Glu) neurotoxicity, we investigated the effects of Pur on Glu-induced axonal transport impairment in primary hippocampal neurons in this study. MATERIALS AND METHODS:Primary hippocampal cultures were prepared from 2-day-old Sprague-Dawley rats. Intracellular calcium concentration [Ca(2+)](i), neurofilament (NF) phosphorylation and protein kinase activity for Cdk5 were measured. Time-lapse imaging technology was used to capture the NF axonal transport in the cultured neurons with transiently transfected fluorescence protein linked to the N-terminus of NF-M (EGFP-NFM). RESULTS:The results showed that Pur significantly diminished the Glu-induced elevation of [Ca(2+)](i) in dose-dependent manner and antagonized the Glu-evoked increases in NF phosphorylation at protein levels. The neurons under the Glu treatment displayed the accumulation of immobile NF clusters in the cell body and the reduced rates of axonal transport of NFs by 72.8% compared to the control neurons. Intriguingly, Pur reversed the slowed rate of the axonal transport by 35.6%. Pur also remarkably attenuated Glu-evoked activation of Cdk5. CONCLUSIONS:Pur may play a role in protecting against Glu-induced NF axonal transport impairment in rat primary hippocampal neurons by inhibiting the increased [Ca(2+)](i) and by impeding the activation of Cdk5.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Zhou J,Wang H,Xiong Y,Li Z,Feng Y,Chen J

doi

10.1016/j.jep.2010.08.005

subject

Has Abstract

pub_date

2010-10-28 00:00:00

pages

150-6

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(10)00552-0

journal_volume

132

pub_type

杂志文章

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