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Cytotoxic and antimicrobial screening of selected terpenoids from Asteraceae species.

Abstract：

:Twelve pure compounds originally obtained through a systematic chemotaxonomical study with Mexican plants of the Asteraceae, were subjected to a cytotoxic and in vitro antimicrobial screening. Three different cell lines in culture (KB, KB-VI and P388) were used in the cytotoxicity assay, while antimicrobial activity was tested against Gram-positive and Gram-negative bacteria, as well as Candida albicans. Of the twelve terpenoids tested, only taraxasterol showed antimicrobial activity against Staphylococcus aureus. The significant cytotoxic activity exhibited by five sesquiterpene lactones, and the moderate cytotoxicity of an eudesmane, is discussed.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Villarreal ML,Alvarez L,Alonso D,Navarro V,García P,Delgado G

doi

10.1016/0378-8741(94)90019-1

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

25-9

issue

1

eissn

0378-8741

issn

1872-7573

pii

0378-8741(94)90019-1

journal_volume

42

pub_type

杂志文章

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