Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE:Acmella uliginosa (Sw.) Cass. is a medicinal herbaceous plant that is commonly used by the Malay community in Malaysia to relieve pain often associated with mouth ulcers, toothache, sore throat, and stomach ache. AIM:The study was carried out to investigate the antinociceptive effect of the methanolic extract of A. uliginosa (Sw.) Cass. flowers (MEAU) using murine models of chemicals and thermal nociception. MATERIALS AND METHODS:Chemicals (acetic acid-induced abdominal constriction and formalin-, capsaicin-, glutamate-induced paw licking test) and thermal models (hot plate test) of nociception in mice were employed to evaluate the MEAU analgesic effect. The extract was given via oral administration at doses of 3, 10, 30 and 100 mg/kg. RESULTS:It was demonstrated that MEAU produced significant antinociceptive response in all the chemical- and thermal-induced nociception models, which indicates the presence of both centrally and peripherally mediated activities. Furthermore, the reversal of antinociception of MEAU by naloxone suggests the involvement of opioid system in its centrally mediated analgesic activity. Moreover, MEAU-treated mice did not show any significant motor performance alterations. No mortality and signs of toxicity were recorded following treatment of the MEAU. CONCLUSION:The results from the present study appear to support the folkloric belief in the medicinal properties of A. uliginosa (Sw.) Cass. which against pain at both central and peripheral levels, in which the central antinociception is probably due to the participation of the opioid receptors.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Ong HM,Mohamad AS,Makhtar N',Khalid MH,Khalid S,Perimal EK,Mastuki SN,Zakaria ZA,Lajis N,Israf DA,Sulaiman MRdoi
10.1016/j.jep.2010.09.030subject
Has Abstractpub_date
2011-01-07 00:00:00pages
227-33issue
1eissn
0378-8741issn
1872-7573pii
S0378-8741(10)00671-9journal_volume
133pub_type
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