Protective effect of Heliotropium foertherianum (Boraginaceae) folk remedy and its active compound, rosmarinic acid, against a Pacific ciguatoxin.

Abstract:

ETHNOPHARMACOLOGICAL RELEVANCE:Senescent leaves of Heliotropium foertherianum Diane & Hilger (Boraginaceae) are traditionally used in the Pacific region to treat Ciguatera Fish Poisoning. This plant contains rosmarinic acid that is known for its multiple biological activities. In the present study, H. foertherianum aqueous extract, rosmarinic acid and its derivatives were evaluated for their capacity to reduce the effect of ciguatoxins. MATERIALS AND METHODS:Aqueous extract of H. foertherianum leaves was prepared and studied for its effects against a Pacific ciguatoxin (P-CTX-1B) in the neuroblastoma cell assay and the receptor binding assay. Rosmarinic acid and six derivatives were also evaluated by means of these bioassays. For this purpose, we have developed an improved synthetic route for caffeic acid 3,4-dihydroxy-phenethyl ester (CADPE). RESULTS:Both the aqueous extract of H. foertherianum leaves and rosmarinic acid showed inhibitory activities against a Pacific ciguatoxin in the above bioassays. Among all the molecules that were evaluated, rosmarinic acid was the most active compound. CONCLUSION:These results confirm further the potential of H. foertherianum in the treatment of Ciguatera Fish Poisoning.

journal_name

J Ethnopharmacol

authors

Rossi F,Jullian V,Pawlowiez R,Kumar-Roiné S,Haddad M,Darius HT,Gaertner-Mazouni N,Chinain M,Laurent D

doi

10.1016/j.jep.2012.05.045

subject

Has Abstract

pub_date

2012-08-30 00:00:00

pages

33-40

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(12)00367-4

journal_volume

143

pub_type

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