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Antiinflammatory activity of extracts from Aloe vera gel.

Abstract：

:We studied the effects of aqueous, chloroform, and ethanol extracts of Aloe vera gel on carrageenan-induced edema in the rat paw, and neutrophil migration into the peritoneal cavity stimulated by carrageenan. We also studied the capacity of the aqueous extract to inhibit cyclooxygenase activity. The aqueous and chloroform extracts decreased the edema induced in the hind-paw and the number of neutrophils migrating into the peritoneal cavity, whereas the ethanol extract only decreased the number of neutrophils. The antiinflammatory agents indomethacin and dexamethasone also decreased carrageenan-induced edema and neutrophil migration. The aqueous extract inhibited prostaglandin E2 production from [14C]arachidonic acid. The chemical tests performed in the aqueous extract for anthraglycosides, reductor sugars and cardiotonic glycosides were positive. In the ethanol extract, the chemical tests performed for saponins, carbohydrates naftoquinones, sterols, triterpenoids and anthraquinones were also positive. In the chloroform extract, the chemical tests performed for sterols type delta 5, and anthraquinones were positive. These results demonstrated that the extracts of Aloe vera gel have antiinflammatory activity and suggested its inhibitory action on the arachidonic acid pathway via cyclooxygenase.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Vázquez B,Avila G,Segura D,Escalante B

doi

10.1016/s0378-8741(96)01476-6

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

69-75

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378874196014766

journal_volume

55

pub_type

杂志文章

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