Abstract：
AIM OF THE STUDY:Red Ginseng roots (Panax ginseng C.A. Meyer) have traditionally been thought to have anti-allergic effects, but their influence on food-induced allergic responses is unclear. MATERIALS AND METHODS:This study examined the effects of a Red Ginseng extract on an ova-albumin (OVA)-evoked allergic reaction in mice. RESULTS AND CONCLUSIONS:The orally administered extract significantly inhibited the increase in OVA-specific IgG(1) (Th(2)) levels in OVA-sensitized mice, but had no effect on OVA-specific IgE (Th(2)) levels. The extract prevented a reduction in IL-12 production and the ratio of IFN-γ (Th(1)) to IL-4 (Th(2)) in splenocytes, and enhanced small intestinal CD8-, IFN-γ-, and IgA-positive cell numbers in the OVA-sensitized mice. These findings suggest that Red Ginseng inhibits allergic reactions to food by preventing reductions in the ratio of IFN-γ to IL-4 and in IL-12 production induced by dietary antigens in spleen cells, and/or increasing the expression of CD8 and IFN-γ in the small intestine. It may also protect against sensitization to antigens as an immunomodulator by increasing intestinal IgA secretion without affecting antigen-specific IgE levels. In conclusion, Red Ginseng roots may be a natural preventative of food allergies.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Sumiyoshi M,Sakanaka M,Kimura Ydoi
10.1016/j.jep.2010.08.012subject
Has Abstractpub_date
2010-10-28 00:00:00pages
206-12issue
1eissn
0378-8741issn
1872-7573pii
S0378-8741(10)00559-3journal_volume
132pub_type
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journal_title：Journal of ethnopharmacology
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更新日期：2015-02-03 00:00:00
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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更新日期：2015-06-20 00:00:00
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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更新日期：2014-11-18 00:00:00
abstract：:Jigrine a polypharmaceutical herbal hepatoprotective formulation containing aqueous extracts of 14 medicinal plants is used in Indian system of medicine (Unani). Jigrine was evaluated for its hepatoprotective activity against galactosamine induced hepatopathy in rats. Galactosamine induced hepatotoxicity resembles hum...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2005-03-21 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2004-04-01 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2007-09-25 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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更新日期：2016-07-21 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2008.08.008
更新日期：2008-11-20 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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更新日期：2019-05-10 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2011-03-08 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2015.02.048
更新日期：2015-06-20 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：1999-06-01 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2010.06.027
更新日期：2010-09-15 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2015-12-04 00:00:00
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更新日期：2015-07-01 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2016-09-15 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2019-04-06 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2013-08-26 00:00:00
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pub_type： 历史文章,杂志文章
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更新日期：1991-04-01 00:00:00
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更新日期：1988-07-01 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2005-02-10 00:00:00
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更新日期：1982-09-01 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2002-10-01 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2011-07-14 00:00:00
abstract：INTRODUCTION:Mirabilis jalapa Linn is a well-studied plant. The indigenous people of Mexico use Mirabilis jalapa to cure many infirmities including dysentery, diarrhea, muscular pain and abdominal colic. In the present investigation, we have further characterized some pharmacological properties of an extract of Mirabil...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2008-02-28 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Fuling, the sclerotium of Poria cocos, was frequently used in traditional Chinese medicine (TCM) formulae for Alzheimer's disease (AD) intervention over the past 10 centuries. And its extracts exhibited significant effects in both cellular and animal models of AD in previous studies. Howe...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2017-02-23 00:00:00
