Alcoholic extract of 'Bacopa monniera' reduces the in vitro effects of morphine withdrawal in guinea-pig ileum.

Abstract:

:The effect of the alcoholic extract of the whole plant of Bacopa monniera (Scrophulariaceae) on morphine withdrawal was evaluated in vitro in guinea-pig ileum. After a 4 min in vitro exposure to morphine, addition of naloxone induced a strong contraction. Addition of various concentrations of the alcoholic extract of B. monniera (100-1000 microg/ml) 15 min before exposure to morphine reduced the naloxone-induced contraction in a dose-dependent manner. The results suggest that B. monniera extract may be useful in reducing the withdrawal symptoms induced by morphine.

journal_name

J Ethnopharmacol

authors

Sumathi T,Nayeem M,Balakrishna K,Veluchamy G,Devaraj SN

doi

10.1016/s0378-8741(02)00139-3

keywords:

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

75-81

issue

2-3

eissn

0378-8741

issn

1872-7573

pii

S0378874102001393

journal_volume

82

pub_type

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