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Anti-inflammatory effects of Z23 on LPS-induced inflammatory responses in RAW264.7 macrophages.

Abstract：

AIM OF THE STUDY:Fissistigma oldhamii (Hemsl.) Merr, a traditional Chinese herb medicine, is used for treating rheumatoid arthritis in China. In our previous study, an effective compound, 7'-(3',4'-dihydroxyphenyl)-N-[(4-methoxyphenyl) ethyl] propenamide (Z23), from this herb has showed potent immunosuppressive effects both in vitro and in vivo. However, its anti-inflammatory effect and mechanism is still need to explore. MATERIALS AND METHODS:We examined the in vitro effects of Z23 on the production of nitric oxide (NO), prostaglandin E2 (PGE2) and cytokines by lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. RESULTS:Z23 significantly decreased the production of PGE2, NO, tumour necrosis factor alpha (TNFalpha) and IL6 production. Inducible nitric oxide synthase (iNOS) and cyclooxygenase2 (COX2) gene expression were also significantly reduced. CONCLUSIONS:These results demonstrated that Z23 exerted an anti-inflammatory effect through modulating the synthesis of several mediators and cytokines involved in the inflammatory process. This study provided evidence to understand the therapeutic effects of Fissistigma oldhamii (Hemsl.) Merr and indicated that Z23 has the potential for treatment of various inflammatory diseases where the overproduction of NO, PGE2 and inflammatory cytokines has been shown to play a role, e.g. rheumatoid arthritis.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Hu XD,Yang Y,Zhong XG,Zhang XH,Zhang YN,Zheng ZP,Zhou Y,Tang W,Yang YF,Hu LH,Zuo JP

doi

10.1016/j.jep.2008.09.026

subject

Has Abstract

pub_date

2008-12-08 00:00:00

pages

447-51

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(08)00510-2

journal_volume

120

pub_type

杂志文章

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