Toxicological studies on the ethanolic extract of Crotalaria juncea seeds in rats.

Abstract:

:The effect of the ethanolic extract of Crotalaria juncea Linn. (Leguminosae) seeds has been assessed on liver, kidney, spleen and adrenals of adult rats. Results revealed that its administration at a dose of 200 mg/kg caused significant alterations. Wet weight of the organs was reduced. Protein and glycogen contents in all the organs were decreased significantly, whereas, the activity of acid and alkaline phosphatase was increased. Histology revealed remarkable disintegration necrosis and degeneration in the liver. Renal tubular cells showed degeneration and exfoliation. Adrenals showed hypertrophy in the region of zona glomerulosa. In the spleen the number of megakaryotic cells and lymphocytes was increased. Administration of the extract therefore not only damaged the liver but other vital organs too were also affected.

journal_name

J Ethnopharmacol

authors

Prakash AO,Dehadrai S,Jonathan S

doi

10.1016/0378-8741(94)01211-h

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

167-76

issue

3

eissn

0378-8741

issn

1872-7573

pii

037887419401211H

journal_volume

45

pub_type

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