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Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L.

Abstract：

:Four taxoids (taxusin, baccatin VI, baccatin III and 1beta-hydroxybaccatin I) and five lignans (lariciresinol, taxiresinol, 3'-demethylisolariciresinol-9'-hydroxyisopropylether, isolariciresinol and 3-demethylisolariciresinol) were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-inflammatory and antinociceptive activity of these compounds were investigated. All the compounds were shown to possess significant antinociceptive activity against p-benzoquinone-induced abdominal contractions, while only lignan derivatives significantly inhibited carrageenan-induced hind paw edema in mice.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Küpeli E,Erdemoğlu N,Yeşilada E,Sener B

doi

10.1016/j.jep.2003.09.005

keywords:

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

265-70

issue

2-3

eissn

0378-8741

issn

1872-7573

pii

S0378874103003118

journal_volume

89

pub_type

杂志文章

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