当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Anti-inflammatory and anti-pyretic activities of earthworm extract-Lampito mauritii (Kinberg).

Anti-inflammatory and anti-pyretic activities of earthworm extract-Lampito mauritii (Kinberg).

Abstract：

AIM OF THE STUDY:Experiments were conducted to understand the therapeutic properties such as anti-inflammatory and anti-pyretic activities of biologically active extract isolated from whole earthworm (Lampito mauritii, Kinberg). MATERIALS AND METHODS:Inflammation in the hind paw of Wistar albino rat, Rattus norvegicus, was induced by histamine, granuloma pouch was induced by turpentine and pyrexia induced by Brewer's yeast in rats were followed as earlier studies. Anti-inflammatory drug-indomethacin and anti-pyretic drug-paracetamol were used as standard drug for comparison. RESULTS:Administration of indomethacin (10mg/kg), paracetamol (150 mg/kg) and/or different doses of earthworm extract (EE) (50, 100 and 200mg/kg) reduced and restored to normal conditions in a dose-dependent manner of histamine and turpentine induced inflammation, and Brewer's yeast induced pyretic in rats. CONCLUSIONS:The most significant inhibition of paw oedema and granuloma and also the significant reduction in hyperpyrexia in rats when treated with standard drugs as well as different doses of EE, reflect the presence of anti-inflammatory and anti-pyretic properties of EE similar to glycoprotein complex (G-90).

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Balamurugan M,Parthasarathi K,Cooper EL,Ranganathan LS

doi

10.1016/j.jep.2008.10.021

subject

Has Abstract

pub_date

2009-01-21 00:00:00

pages

330-2

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(08)00590-4

journal_volume

121

pub_type

杂志文章

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