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Aqueous extract of Chrysobalanus icaco leaves, in lower doses, prevent fat gain in obese high-fat fed mice.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Due to the rise in obesity, the necessity for resources and treatments that could reduce the morbidity and mortality associated to this pandemia has emerged. The development of new anti-obesity drugs through herbal sources has been increasing in the past decades which are being used not only as medicine but also as food supplements. Previous studies with the aqueous extract of Chrysobalanus icaco L (AECI) have demonstrated activity on lowering blood glucose levels and body weight. AIM OF THE STUDY:Investigate C. icaco effects in overall adiposity and glycemic homeostasis. MATERIAL AND METHODS:C57BL/6J mice were randomly assigned to standard chow (SC) or high-fat diet (HFD) and treated with AECI in 0.35mg/mL or 0.7mg/mL concentrations ad libitum. Food intake, feed efficiency, metabolic efficiency, body, fat pads and gastrocnemius weight, adiposity index, serum lipids, fecal lipid excretion, locomotor activity in the open field test and insulin and glucose tolerance tests were analyzed and compared. The major components of the extract were demonstrated through HPLC and its antioxidant activity analyzed through DPPH and lipid peroxidation. RESULTS:The AECI in the 0.35mg/mL concentration did not affect food intake or body weight. However, it promoted lower adipose tissue gain, TG levels, and fecal lipid excretion, increased locomotor activity and lean mass weight, and normalized insulin sensitivity and glucose tolerance. Moreover, AECI showed the presence of myricetin 3-O-glucuronide, rutin, quercitrin and myricitrin and demonstrated high-antioxidant activity. CONCLUSIONS:AECI in lower concentrations can prevent fat storage or enhance fat utilization through the increase of locomotor activity. Also, this reinforces its ability to maintain glucose homeostasis through the normalization of insulin sensitivity and glucose tolerance despite the high-fat diet intake. These activities could be associated to the extract's polyphenol content.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

White PA,Cercato LM,Batista VS,Camargo EA,De Lucca W Jr,Oliveira AS,Silva FT,Goes TC,Oliveira ER,Moraes VR,Nogueira PC,De Oliveira E Silva AM,Quintans-Junior LJ,Lima BS,Araújo AA,Santos MR

doi

10.1016/j.jep.2015.12.047

subject

Has Abstract

pub_date

2016-02-17 00:00:00

pages

92-100

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(15)30299-3

journal_volume

179

pub_type

杂志文章

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Aqueous extract of Chrysobalanus icaco leaves, in lower doses, prevent fat gain in obese high-fat fed mice.