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Oligosaccharidic fractions derived from Triticum vulgare extract accelerate tissutal repairing processes in in vitro and in vivo models of skin lesions.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Triticum vulgare has been extensively used in traditional medicine thanks to its properties of accelerating tissue repair. The aqueous extract of Triticum vulgare (TVE) is currently an active component used by Farmaceutici Damor in the manufacture of certain pharmaceutical products already marketed in Italy and abroad under the brand name Fitostimoline(®), in the formulation of cream and medicated gauze and is commonly used for the treatment of decubitus ulcers, sores, burns, scarring delays, dystrophic diseases, and, more broadly, in the presence of problems relating to re-epithelialization or tissue regeneration. The active components of Fitostimoline(®)-based products determine a marked acceleration of tissutal repairing processes, stimulate chemotaxis and the fibroblastic maturation, and significantly increase the fibroblastic index, which are crucial points in the repairing processes. The aim of the present paper was to identify and characterize the active fractions of TVE responsible for the pharmacological effect in tissutal repairing processes. MATERIALS AND METHODS:Several fractions obtained from TVE by ultrafiltration procedures and HPAE chromatography were tested to measure their growth-enhancing activity on NIH-3T3 fibroblasts. The healing action of the same fractions, prepared as cream formulation, was assessed in rat subjected to two different models of skin lesion, skin scarification and excision. RESULTS:Our results showed a pro-proliferative effect of the fractions ST-98 and K>1000 in NIH-3T3 fibroblasts. Moreover these fractions formulated as cream preparations were effective also in in vivo models of skin lesion. CONCLUSIONS:The results of the present study showed that these active fractions of TVE are responsible for its pro-proliferative effect.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Sanguigno L,Minale M,Vannini E,Arato G,Riccio R,Casapullo A,Monti MC,Riccio R,Formisano S,Di Renzo G,Cuomo O

doi

10.1016/j.jep.2014.10.051

subject

Has Abstract

pub_date

2015-01-15 00:00:00

pages

198-208

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(14)00761-2

journal_volume

159

pub_type

杂志文章

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Oligosaccharidic fractions derived from Triticum vulgare extract accelerate tissutal repairing processes in in vitro and in vivo models of skin lesions.