当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-kappaB and ROS production in LPS-activated RAW 264.7 cells.

Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-kappaB and ROS production in LPS-activated RAW 264.7 cells.

Abstract：

:Post-treatment with nobiletin (5,6,7,8,3',4'-hexamethoxy flavone), which was purified from the fruit peel of Citrus sunki Hort. ex Tanaka, at concentration 6-50 microM significantly suppressed NF-kappaB transcriptional activation, NO and PGE(2) production, and iNOS and COX-2 protein expression in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Nobiletin inhibited neither LPS-induced phosphorylation/degradation of inhibitory kappaB-alpha nor LPS-induced nuclear translocation of NF-kappaB. However, it interrupted the DNA-binding activity of activated NF-kappaB. As reactive oxygen species (ROS) are also known to regulate the activation of NF-kappaB, we tested the effect of nobiletin on LPS-induced ROS generation. Nobiletin significantly inhibited LPS-induced intracellular ROS production in RAW 264.7 cells. These results suggest that nobiletin may exert an anti-inflammatory effect through the interruption of NF-kappaB DNA-binding activity and the suppression of ROS generation.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Choi SY,Hwang JH,Ko HC,Park JG,Kim SJ

doi

10.1016/j.jep.2007.05.021

subject

Has Abstract

pub_date

2007-08-15 00:00:00

pages

149-55

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(07)00267-X

journal_volume

113

pub_type

杂志文章

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